Beshanzuamide A, an unprecedented prenylated indole alkaloid produced by sp. Y-2 from the critically endangered conifer .

A structurally unprecedented prenylated indole alkaloid, beshanzuamide A (1), together with five known analogues (2-6) were isolated and identified from the endophytic fungus derived from the needles of the critically endangered conifer . The new structure was determined by extensive spectroscopic methods and quantum chemical calculations of NMR and electronic circular dichroism (ECD) data. Compound 1 features a unique ,-spiroketal/δ-lactone motif connected to a pyranoindole-derived bicyclo[2.

Chromenopyridin A, a new -methoxy-1-pyridone alkaloid from the endophytic fungus P-6 isolated from the critically endangered conifer .

A new -methoxy-1-pyridone alkaloid [chromenopyridin A ()] and four known compounds (-) were isolated and identified from the endophytic fungus P-6, which was derived from the bark of the critically endangered conifer . Their structures were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction. Among the isolates, compound showed considerable cytotoxicities against the A549 and Hela human cancer cell lines, with IC values of 14.

Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum.

In this study, we isolated an endophytic Streptomyces sp. strain, WP-1, from surface-sterilized barks of Pinus dabeshanensis, an endangered Chinese plant. WP-1 showed strong antifungal activity against diverse pathogenic fungi, such as Fusarium oxysporum, Rhizoctonia solani, Phytophthora infestan, and Candida albicans.

Two new sterol derivatives isolated from the endophytic fungus YP-2.

Two new sterol derivatives, namely ergosterimide B () and demethylincisterol A (), along with eleven known metabolites (), were isolated from the rice fermentation culture of YP-2. The chemical structures were elucidated by detailed NMR and MS spectroscopic data and by comparison with reported data. Newly isolated compound and known compound were evaluated for their cytotoxicities against the A549 and HepG2 cell lines.

Aflatoxins from the endophytic fungus Y-2 isolated from the critically endangered conifer .

Two new [asperxins A () and B ()] and four known (-) aflatoxins were isolated and identified from the endophytic fungus Y-2, which was derived from the needles of the critically endangered conifer . Their structures were elucidated by extensive spectroscopic methods. Among the isolates, compounds and showed considerable cytotoxicities against the A549 and Hela human cancer cell lines, with IC values in the range of 7.