Publications by authors named "Yuan-Ming Pan"
Article Synopsis
- Research on gastrointestinal mucosal adenocarcinoma (GMA) has been limited, and this study aims to understand its prognosis and develop a predictive model for post-operative survival.
- Using data from the Surveillance, Epidemiology, and End Results database, the study analyzed various clinical factors affecting GMA outcomes through a three-part cohort approach (discovery, validation, and test groups).
- The resulting predictive model demonstrated decent accuracy (AUC ranging from 0.7244 to 0.7433) and highlighted that factors like regional node examination and chemotherapy significantly improve patient survival, especially for challenging cases like mucinous gastric adenocarcinoma.
Background: The composition of intestinal flora in Chinese and Japanese has been reported in many studies but that in infants aged 0-6 years old has not been studied yet.
Methods: The distribution characteristics of the fecal flora of infants in Beijing (n=84) and Japan (n=53) were analyzed using 16S rRNA gene sequencing analysis.
Results: This study showed the higher relative abundance of Erysipelotrichaceae_ UCG-003 and Anaerostipes in male group that of , , and in female group, especially , which was not detected in male group.
Background/aims: Colonoscopy screening has been accepted broadly to evaluate the risk and incidence of colorectal cancer (CRC) during health examination in outpatients. However, the intrusiveness, complexity and discomfort of colonoscopy may limit its application and the compliance of patients. Thus, more reliable and convenient diagnostic methods are necessary for CRC screening.
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- * The study involved analyzing MZF1 protein levels in different tissue samples and gastric cell lines through techniques such as immunohistochemical staining and quantitative PCR.
- * Results showed that lower MZF1 levels were linked to gastric cancer severity and poor patient outcomes, suggesting that MZF1 could serve as a valuable early predictive and prognostic biomarker for gastric cancer.
Article Synopsis
- STAT3 signaling is crucial in gastric cancer (GC) progression through its interaction with EZH2, which enhances STAT3 activity via increased tyrosine phosphorylation.
- Research showed that high levels of both STAT3 and EZH2 in GC tissues correlate with poor patient outcomes and advanced disease stages.
- Targeting the STAT3-EZH2 relationship may improve treatment effectiveness, as combining siSTAT3 with an EZH2 inhibitor increased cancer cell apoptosis.
Background: Dysregulated metallothionein 2A (MT2A) has been implicated in carcinogenesis. The purpose of this study was to investigate the expression of MT2A in gastric cancer (GC) and its correlation with prognosis.
Methods: Reverse transcription-polymerase chain reaction and real-time polymerase chain reaction were used to detect the mRNA expression of MT2A in 12 GC cell lines, normal gastric epithelial GES-1 cells, and 36 GC and adjacent normal tissues.
Aim: To investigate role of putative mitogen-activated protein kinase activator with WD40 repeats (MAWD)/MAWD binding protein (MAWBP) in gastric cancer (GC).
Methods: MAWBP and MAWD mRNA expression level was examined by real-time reverse transcriptase-polymerase chain reaction and semi-quantitative polymerase chain reaction in six GC cell lines. Western blotting was used to examine the protein expression levels.
Ethnopharmacological Relevance: 12-Deoxyphorbol 13-palmitate (G) is one toxic compound isolated from Euphorbia fischeriana, an Asian spice used for cancer treatment as a folk remedy. However, whether 12-deoxyphorbol 13-palmitate affects angiogenesis remains unclear.
Aim Of The Study: To explore the in vitro and in vivo antiangiogenic effects of 12-deoxyphorbol 13-palmitate and its underlying mechanisms.
Background: Programmed cell death 5 (PDCD5) expression is reduced in various human tumor cells, and the protein concentration and nuclear translocation of PDCD5 is also observed during tumor cell apoptosis.
Aims: The purpose of this study was to investigate the differential expression of PDCD5 in six gastric cell lines, and to explore the changes of biological behavior mechanism underlying enhanced apoptosis-inducing effects of cisplatin by PDCD5 over-expression on gastric cancer BGC823 cells.
Methods: RT-PCR and real-time PCR were used to determine PDCD5 expression.