Transanal minimally invasive surgery endoscopic mucosal resection for rectal benign tumors and rectal carcinoids: A retrospective analysis.

Background: Transanal minimally invasive surgery (TAMIS) is a good choice for resection of rectal neoplasms. Endoscopic mucosal resection (EMR) is also widely used in the treatment of benign rectal tumors such as rectal polyps and rectal adenomas. However, no studies have compared the outcome of TAMIS and EMR.

Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice.

Aim: To investigate the effect of epigallocatechin gallate (EGCG) on structural changes of gut microbiota in colorectal carcinogenesis.

Methods: An azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis mouse model was established. Forty-two female FVB/N mice were randomly divided into the following three groups: group 1 (10 mice, negative control) was treated with vehicle, group 2 (16 mice, positive control) was treated with AOM plus vehicle, and group 3 (16 mice, EG) was treated with AOM plus EGCG.

Suppression of colorectal tumorigenesis by recombinant enterotoxin-2 .

Aim: To evaluate the impact of recombinant enterotoxin-2 (BFT-2, or Fragilysin) on colorectal tumorigenesis in mice induced by azoxymethane/dextran sulfate sodium (AOM/DSS).

Methods: Recombinant proBFT-2 was expressed in strain Rosetta (DE3) and BFT-2 was obtained and tested for its biological activity colorectal adenocarcinoma cell strains SW-480. Seventy C57BL/6J mice were randomly divided into a blank (BC; = 10), model (AD; = 20), model + low-dose toxin (ADLT; = 20, 10 μg), and a model + high-dose toxin (ADHT; = 20, 20 μg) group.

Glucagon-like peptide-2 protects impaired intestinal mucosal barriers in obstructive jaundice rats.

Aim: To observe the protective effect of glucagon-like peptide-2 (GLP-2) on the intestinal barrier of rats with obstructive jaundice and determine the possible mechanisms of action involved in the protective effect.

Methods: Thirty-six Sprague-Dawley rats were randomly divided into a sham operation group, an obstructive jaundice group, and a GLP-2 group; each group consisted of 12 rats. The GLP-2 group was treated with GLP-2 after the day of surgery, whereas the other two groups were treated with the same concentration of normal saline.

Evaluation of specific fecal protein biochips for the diagnosis of colorectal cancer.

Aim: To develop and initially test a potential fecal protein biochip for the screening of colorectal cancer (CRC).

Methods: Fecal protein from 20 colorectal cancer patients and 20 healthy controls were extracted from all of the fecal samples and screened for proteomic differences using a Biotin label-based protein array. Candidate proteins were then verified by ELISA.

Does a decrease of NK cells in the appendix increase the risk of developing colon cancer?

Background/aims: Epidemiological studies indicate that relevance between appendix and colon cancer is controversial, but unfortunately, there is no data based on examination of immune indicator to reveal the relativity.

Methodology: This study explored the relation-ship between appendix immunity and the right colon cancer by detecting the presence of NK cells in appendix tissues with immunohistochemistry.

Results: The number of NK cells in the appendix tissue was the highest in patients with appendix inflammation (37.

[Preparation of carbon nanoparticle paclitaxel suspension and pharmacokinetic study of intraperitoneal chemotherapy].

Objective: To prepare carbon nanoparticle-paclitaxel suspension(CNPS) and to study the pharmacokinetics of intraperitoneal chemotherapy with CNPS.

Methods: Saturated absorption capacity of carbon nanoparticle suspension (CNS) and paclitaxel were detected by high performance liquid chromatography in order to prepare the above suspension. Wistar rats were randomly divided into the experimental group (A) and the control group (B), to which intraperitoneal injections of CNPS and paclitaxel were given respectively.