Resveratrol prevents steroid-induced osteonecrosis of the femoral head via miR-146a modulation.

The purpose of this study was to investigate the possible use of resveratrol (Res) to reverse abnormal osteogenesis/osteoclastogenesis activity that occurs during femoral head osteonecrosis and to explore the detailed mechanisms. Application of Res to bone marrow-derived mesenchymal stem cells in vitro promoted survival, inhibited apoptosis, and downregulated expression of reactive oxygen species expression. Moreover, Res application was associated with elevated microRNA-146a (miR-146a) expression, osteogenic differentiation, and suppressed osteoclastic differentiation, which were markedly reversed by miR-146a inhibitor.

Effects of Unilateral Tourniquet Used in Patients Undergoing Simultaneous Bilateral Total Knee Arthroplasty.

Objective: To assess the benefits of use of a tourniquet in one limb in patients undergoing simultaneous bilateral total knee arthroplasty (TKA).

Methods: A prospective randomized trial was designed to evaluate the outcomes of unilateral tourniquet use during simultaneous bilateral TKA. A total of 52 (36 women and 16 men) patients with osteoarthritis who underwent simultaneous bilateral primary TKA between January 2010 and January 2015 were assigned randomly to tourniquet (TG) or non-tourniquet (NG) groups prior to surgery.

[Influence of Activated Sludge Surface Properties on Flocculating Settling and Effluent Suspend Solid].

In this paper, the influence of the surface properties of the activated sludge on flocculating settling and ESS was studied in seven different sewage treatment plants in Beijing, such as the sludge volume index (SVI), the protein/carbohydrate (P/C) ratio in extracellular polymeric substance, Zeta potential, two-dimensional fractal dimension(). The relationships between the surface properties of the activated sludge and flocculation ability (FA) or effluent suspend solid(ESS) were also analyzed. The results showed that no obvious correlation was obtained between SVI and FA or ESS, but obvious negative correlation between the FA and ESS (=0.

Improved repair of bone defects with prevascularized tissue-engineered bones constructed in a perfusion bioreactor.

Vascularization of tissue-engineered bones is critical to achieving satisfactory repair of bone defects. The authors investigated the use of prevascularized tissue-engineered bone for repairing bone defects. The new bone was greater in the prevascularized group than in the non-vascularized group, indicating that prevascularized tissue-engineered bone improves the repair of bone defects.