Publications by authors named "Yuan-Jun Gu"
Therapeutic angiogenesis by intramuscular injection of fibrin particles into ischaemic hindlimbs.
Clin Exp Pharmacol Physiol
July 2006
Article Synopsis
- Fibrin gel has been tested for its ability to enhance the formation of new blood vessels in a rabbit model of acute hindlimb ischaemia, where the left femoral artery is surgically removed.
- Seven days post-surgery, different groups of rabbits received varying doses of fibrin particles (FP) directly into ischaemic muscle, while a control group received saline.
- Results showed that the 5 mg FP treatment significantly improved blood vessel development, increased capillary density, and enhanced blood flow compared to controls, suggesting FP can be an effective treatment for promoting angiogenesis in ischaemic conditions.