[Preparation of recombinant retrovirus pRevTRE-E77.43 and its protective effect in a mouse model of infection].

Objective: To explore the biological functions of E77.43, a gene segment of , in treating infection.

Methods: Recombinant retroviral vectors of pRevTREE77.

Karyopherin alpha 2 (KPNA2) is associated with the natural resistance to Schistosoma japanicum infection in Microtus fortis.

Microtus fortis is a naturally vertebrate host resistant to Schistosoma japonicum infection. In order to understand the molecular mechanism and identify the molecules related to the natural resistance to S. japanicum infection of M.

Identification of the resistance of a novel molecule heat shock protein 90alpha (HSP90alpha) in Microtus fortis to Schistosoma japonicum infection.

Microtus fortis is a naturally resistant vertebrate host of Schistosoma japonicum by preventing completion of parasite's life cycle. Sera of M. fortis were found to have anti-schistosome effect in vitro and in vivo.

[In vitro killing activity of the fractional proteins from microtus fortis serum to Schistosoma japonicum juveniles].

Objective: To explore the killing effect of different fractional proteins from Microtus fortis (Mf) serum to S. japonicum juveniles, and to find possible association of the proteins with the natural resistance to schistosome infection.

Methods: The proteins in Mf serum were separated by means of ion-exchange column chromatography and molecular sieve column chromatography.

[Genetic modification of porcine organs for human in xenotransplantation].

Xenotransplantation (XP) from pig into human has been considered as means to overcome the great lack of donor organ available in transplantation surgery. In order to weaken rejection between human and pig,approaches of gene targeting have been proposed to eliminate "rejection gene"alpha-1,3GT from porcine cells directly and accurately.alpha-1,3GT knockout pigs can be produced by nuclear transfer cloning with the porcine cells(knocking out alpha-1,3GT).

[Comparison of specific genomic DNA fragment between Microtus fortis calamorum and Microtus fortis fortis].

Microtus fortis(Taxonomy ID: 100897), also named as reed vole, is classified as Microtus, Micotinae, Cricetidae, Rodentia, Mammalia on taxonomy. Microtus fortis mainly distributes in China. Some areas of Russia, North Korea and Mongolia close to Northeast borderland of China also have a small number of Microtus fortis in distribution.