The relationship between the radiation dose of pelvic-bone marrow and lymphocytic toxicity in concurrent chemoradiotherapy for cervical cancer.

Objective: The purpose of this study is to verify the correlation between medium and low radiation doses of the pelvic-bone marrow and the incidence of lymphocytic toxicity during concurrent chemoradiotherapy for cervical cancer.

Materials And Methods: This research included 117 cervical cancer patients, who received concurrent chemoradiotherapy. Radiotherapy included external-beam radiation therapy and brachytherapy.

Identification and validation of novel DNA methylation markers for early diagnosis of lung adenocarcinoma.

Lung cancer has the highest mortality of all cancers worldwide. Epigenetic alterations have emerged as potential biomarkers for early diagnosis of various cancer tissue types. To identify methylation markers for early diagnosis of lung adenocarcinoma, we aimed to integrate genome-wide DNA methylation and gene expression data from The Cancer Genome Atlas.

Silencing of ST6Gal I enhances colorectal cancer metastasis by down-regulating KAI1 via exosome-mediated exportation and thereby rescues integrin signaling.

Aberrant sialylation has long been correlated with human cancer. Increased ST6 Gal I (β-galactoside α 2, 6 sialyltransferase) and consequently higher levels of cell-surface α 2, 6 sialylation has been associated with human colorectal cancer (CRC) metastasis. We have extensive circumstantial data that sialylation is connected to cancer metastasis, but we do not understand in detail how sialylation can switch on/off multiple steps in cancer metastasis.

Development of a 3D optical scanner for evaluating patient-specific dose distributions.

Purpose: This paper describes the hardware and software characteristics of a 3D optical scanner (P3DS) developed in-house. The P3DS consists of an LED light source, diffuse screen, step motor, CCD camera, and scanner management software with 3D reconstructed software.

Materials And Method: We performed optical simulation, 2D and 3D reconstruction image testing, and pre-clinical testing for the P3DS.

Patient performance-based plan parameter optimization for prostate cancer in tomotherapy.

The purpose of this study is to evaluate the influence of treatment-planning parameters on the quality of treatment plans in tomotherapy and to find the optimized planning parameter combinations when treating patients with prostate cancer under different performances. A total of 3 patients with prostate cancer with Eastern Cooperative Oncology Group (ECOG) performance status of 2 or 3 were included in this study. For each patient, 27 treatment plans were created using a combination of planning parameters (field width of 1, 2.