Publications by authors named "Yuan-Jie Cai"
Article Synopsis
- - Nischarin is an integrin-binding protein acting as a tumor suppressor in breast cancer, mainly affecting cell migration and invasion.
- - The study investigates how Nischarin regulates the epithelial-mesenchymal transition (EMT), which is crucial for cell movement, by analyzing mRNA and protein levels after its overexpression and knockdown.
- - Results show that Nischarin inhibits cell proliferation and migration by increasing E-cadherin levels and decreasing multiple EMT-related transcription factors, thus suppressing the EMT process.
Fibroadenomas (FAs) are the most common fibroepithelial lesions and the most common benign tumors of the breast in women of reproductive age. Although MED12 mutations, an overwhelming majority of all mutations, and some other gene mutations have been found in FAs, the genomic landscapes of FAs are still not completely clear and the genomic mutation spectrums of FAs in Chinese population remains unknown. Here, by performing whole exome sequencing of 12 FAs and the corresponding normal breast tissues in Chinese Han population, we observed the somatic and germline landscapes of genetic alterations.
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