Impact of sodium butyrate on stroke-related intestinal injury in diabetic mice: interference with Caspase-1/GSDMD pyroptosis pathway and preservation of intestinal barrier.

Diabetic stroke-associated acute intestinal injury is characterized by high mortality, disability, and poor prognosis due to the lack of effective therapies. Our prior research demonstrated that administration of 300 mg/kg sodium butyrate (NaB) can improve neurological outcomes post-diabetic stroke. Nonetheless, whether the effect of NaB is related to intestinal regulation, along with its underlying mechanisms, remains uncertain.