Publications by authors named "Yuan-Chuen Lin"

Serological methods are relatively convenient and simple for the detection of pathogens for front-line workers. On-site visualization of the test results plays a pivotal role in the process. However, an efficient, universal labeling agent for antibodies is needed for the development of efficient serological detection tools.

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To ensure the optimal infectivity on contact with host cells, pathogenic Pseudomonas syringae has evolved a complex mechanism to control the expression and construction of the functional type III secretion system (T3SS) that serves as a dominant pathogenicity factor. In this study, we showed that the hrpF gene of P. syringae pv.

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Article Synopsis
  • Researchers developed a novel biosensing strategy that combines surface-enhanced Raman scattering (SERS) nanoprobes with a microfluidic device to quickly detect pathogens like Salmonella and Neisseria.
  • The SERS nanoprobes are created by attaching specific antibodies to silica-coated nanoparticles, which enhance Raman signals for accurate identification of bacteria at low concentrations, even down to a single bacterium.
  • This method is faster and more sensitive than traditional ELISA tests, allowing for a total assay time of under 2 hours while using significantly less antibody.
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We have previously demonstrated that the meningococcal antigen Ag473 in the presence of Freund's adjuvant can elicit protective immune responses in mouse challenge model. In this study, we evaluated the structural requirement for the immunological activity and the possible signaling pathway of recombinant Ag473 antigen produced in E. coli.

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Erwinia chrysanthemi (Ech) RA3B produces a large amount of blue indigoidine. Using Tn5-induced mutagenesis, three indigoidine-deficient mutants were generated. Followed by library screening, a 5.

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