Publications by authors named "Yuan Y"
AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation.
Signal Transduct Target Ther
October 2024
Article Synopsis
- AXIN1 is a crucial scaffold protein that regulates cell fate and plays a significant role in antiviral immunity against both DNA and RNA viruses.
- It stabilizes the transcription factor IRF3 by preventing its degradation and increases IRF3 phosphorylation during viral infections, enhancing the production of interferon.
- The small molecule KYA1797K improves AXIN1 and IRF3 interactions, potentially serving as an effective antiviral treatment, with reduced AXIN1 levels linked to poorer survival rates in HBV-associated liver cancer patients.
Usefulness of next-generation sequencing for laboratory diagnosis of rickettsiosis.
PLoS Negl Trop Dis
October 2024
Article Synopsis
- - The study examined six patients diagnosed with various rickettsiosis infections using metagenomic next-generation sequencing (mNGS), which can be challenging for traditional laboratory diagnostics.
- - One patient with Japanese spotted fever was quickly diagnosed through mNGS, while two others with Rickettsia felis infections showed the bacterium in lung samples; both patients were immunocompromised due to cancer treatments.
- - Three additional patients, presenting with fever and eschar, had negative Weil-Felix test results, but mNGS confirmed the presence of Orientia tsutsugamushi, indicating scrub typhus; this highlights mNGS as a vital tool alongside serology for diagnosing rickettsiosis.
Multi-label remote sensing classification with self-supervised gated multi-modal transformers.
Front Comput Neurosci
September 2024
Article Synopsis
- - The growing success of Transformers in machine learning is generating interest in its application to remote sensing (RS), but research is limited by the lack of large labeled datasets and data variability across platforms.
- - The study introduces a multi-modal fusion mechanism (MGSViT) that combines multispectral (MS) and synthetic aperture radar (SAR) data using a pre-trained ViT model and gated fusion units for improved feature extraction.
- - Results indicate that this new method surpasses existing algorithms in classification tasks, demonstrating its effectiveness in multi-modal data fusion for remote sensing applications.
Article Synopsis
- Single-atom metals (SAMs), like Sn-SAMs, face challenges in catalytic performance due to low metal loading; this study introduces a method to create ultrahigh-loading Sn-SAMs on a carbon nanorings matrix.
- The formation process involves converting oxygen-coordinated SnO to nitrogen-coordinated Sn-N while promoting diffusion throughout the carbon matrix using gaseous intermediates.
- The resulting Sn-SAMs@CNR shows impressive performance in sodium-ion batteries, with high durability and a minimal capacity decay over extensive cycling, suggesting a promising strategy for enhancing energy storage materials.
Article Synopsis
- Oxalate nephropathy involves calcium oxalate crystals that cause damage to renal cells and trigger inflammation; the exact mechanisms, particularly relating to immune cell involvement, are not fully understood.
- This study tested the hypothesis that NINJ1, which causes membrane rupture and releases inflammatory signals, plays a key role in worsening kidney damage during oxalate nephropathy.
- Results show that deleting Ninj1 in immune cells reduces kidney injury by lowering harmful signals and cell death, highlighting the importance of NINJ1 in this type of kidney disease.
Article Synopsis
- Ferroptosis is a special type of cell death that helps stop tumors, including ovarian cancer, and is linked to a drug called Artesunate (ART).
- Researchers studied how ART triggers ferroptosis to fight ovarian cancer by looking at gene changes and using various tests on cells and mice.
- They discovered that ART affects certain genes (like HOXC11 and PROM2) and pathways (PI3K/AKT) to promote cell death and limit tumor growth.
Article Synopsis
- The study investigates how the hormone methyl jasmonate (MeJA) affects the metabolic pathways of 'Nanguo' pears during ripening, particularly in terms of carbohydrate and amino acid metabolism.
- Using advanced mass spectrometry techniques, researchers analyzed changes in metabolites after MeJA treatment and identified key genes and regulatory networks involved in these metabolic processes.
- The findings provide insights into the molecular mechanisms behind changes in fruit quality, offering a foundation for enhancing the internal quality of pears through targeted treatments.
Article Synopsis
- Cupric ions can hinder the biological processes involved in removing nitrogen by affecting specific enzymes like nitrite reductase and nitric oxide reductase.
- Pseudomonas sp. NY1, when cultured at 15 °C with low levels of cupric ions, showed improved nitrogen degradation, with better removal rates for ammonium and nitrite.
- However, while low levels of cupric ions enhance certain activities related to nitrogen conversion, higher concentrations can have the opposite effect, negatively impacting enzyme activity and electron transport.
Inflammatory bowel disease (IBD) poses persistent challenges due to its chronic and recurrent nature, exacerbated by the unsatisfactory outcomes of the traditional treatment approaches. In this study, we developed a dietary supplement, selenium-enriched (SeY), to alleviate dextran sulfate sodium-induced colitis in mice. The newly developed functional food shows dual-functional activity, acting both as a probiotic and a reliable source of organic selenium.
View Article and Find Full Text PDFA novel double antibody sandwich quantitative ELISA for detecting porcine epidemic diarrhea virus infection.
Appl Microbiol Biotechnol
October 2024
Article Synopsis
- Porcine epidemic diarrhea (PED) is a highly contagious disease affecting pigs, leading to severe economic losses in the pig farming industry, especially among piglets due to high mortality rates.
- A new double-antibody sandwich quantitative enzyme-linked immunosorbent assay (DAS-qELISA) was developed using specific antibodies against the PEDV nucleocapsid protein, capable of detecting low levels of the virus.
- The DAS-qELISA demonstrated excellent reliability and reproducibility, showing high correlation with established methods for detecting PEDV, making it a valuable tool for diagnosing and controlling this disease.
Design and Improvement of Bone Adhesive in response to Clinical Needs.
Adv Healthc Mater
December 2024
Fracture represents one of the most common diagnoses in contemporary medical practice, with the majority of cases traditionally addressed through metallic device fixation. However, this approach is marred by several drawbacks, including prolonged operative durations, considerable expenses, suboptimal applicability to comminuted fractures, increased infection risks, and the inevitable requirement for secondary surgery. The inherent advantages of bone adhesives in these fields have garnered the attention of orthopedic surgeons, who have commenced utilizing biocompatible and biodegradable bone adhesives to bond and stabilize bone fragments.
View Article and Find Full Text PDFMetal ions show tremendous promise for tumor therapy due to their critical roles in many important catalytic circulations and immune processes. However, the valence state variability and systemic side-effects of metal ions cause ineffective ion enrichment in tumor cells, which limit their further application. Here, a Mn ion delivery system (Mn-HNT) is constructed based on halloysite nanotubes (HNT) via an ion-engineered strategy.
View Article and Find Full Text PDFBackground: To investigate whether radiomics models derived from pretreatment CT could help to predict response to immunotherapy in oral squamous cell carcinoma (OSCC).
Methods: Retrospectively, a total of 40 patients with measurable OSCC were included. The patients were divided into responder group and non-responder group according to the comparison of pre-treatment and post-treatment CT findings.
Article Synopsis
- The study focused on finding a better way to identify human leucocyte antigens (HLA) and human platelet antigens (HPA) in blood donors.
- Researchers tested 268 platelet donors using a special long-read sequencing method to see their genetic makeup and how common different alleles are.
- They discovered new genetic variations in several HPA systems and established a new technique that can help create a better blood platelet donor bank.
Article Synopsis
- * Thirty patients participated, where the experimental group received traditional dysphagia treatment plus motor imagery for 14 days, while the control group only received conventional treatment.
- * Results showed significant improvements in swallowing assessments and enhanced brain activation in key areas related to motor control in the experimental group, suggesting this approach could be an effective addition to dysphagia rehabilitation.
RANEY® nickel is extensively applied in industrial settings for its low cost and ease of scale-up. Nevertheless, its poor activity and high energy consumption restrict the progress of large-scale hydrogen production. Here, we used a RANEY® nickel substrate combined with a one-step electrodeposition method to prepare porous NiFe@RN bifunctional catalysts.
View Article and Find Full Text PDFAn Overview of Multifaceted Applications and the Future Prospects of Glyceroglycolipids in Plants.
J Agric Food Chem
October 2024
Article Synopsis
- * They are mostly found in the inner membranes of chloroplasts and are crucial for photosynthesis, energy conversion, and plant responses to environmental stress.
- * The review discusses GGLs' distribution, synthesis, biological activities (like anti-inflammatory and antiviral effects), and their potential applications in pharmaceuticals, food, and cosmetics, emphasizing their role in holistic health.
Article Synopsis
- Scientists used special data from a detector to look for rare particle decays of a type called the D_{s}^{+} decay, focusing on how it might change into other particles like kaons or pions.
- They found strong evidence for the decay D_{s}^{+}→π^{+}ϕ and also discovered a new decay D_{s}^{+}→ρ^{+}ϕ, both involving particles that decay into pairs of electrons.
- However, they didn't find strong signals for three other types of decays they were looking for, and set limits on how often those changes could happen.
Article Synopsis
- Cardiac remodelling is a key factor in cardiovascular diseases, and this study investigates the role of TRAF7, a protein linked to heart defects, in promoting pathological cardiac hypertrophy.
- Researchers utilized mouse models and various experimental techniques to examine how TRAF7 affects heart cell growth and dysfunction, revealing that higher levels of TRAF7 worsen heart enlargement, while reducing TRAF7 has a protective effect.
- The study found that TRAF7 influences heart hypertrophy by interacting with another protein, ASK1, which leads to its activation and contributes to the disease process, suggesting that TRAF7 could be a potential target for new treatments.
Effects of Pilates on Body Posture: A Systematic Review.
Arch Rehabil Res Clin Transl
September 2024
Objective: To perform a systematic review of the effects of Pilates on common body postures.
Data Sources: Web of Science, PubMed, Scopus, Science Direct, Springer Link, and CNKI. The search year is set from January 1, 2019, to November 15, 2023.
Article Synopsis
- Ischemic stroke is a major health concern for older adults, prompting research into the relationship between gut microbiota and recovery in stroke patients.
- This study aimed to determine if gut microbiota from younger individuals can enhance recovery in older stroke patients and aged mouse models by promoting angiogenesis through short-chain fatty acids (SCFAs).
- Results showed that older stroke patients had reduced gut microbiota diversity and lower levels of acetate, which negatively correlated with angiogenesis, while transplanting younger microbiota in aged mice improved recovery by enhancing angiogenesis, linked to higher acetate levels.
Clinical and Bacterial Characteristics of Bloodstream Infections Caused by in Western China.
Can J Infect Dis Med Microbiol
September 2024
Article Synopsis
- Bloodstream infections (BSIs) show a high in-hospital mortality rate of 25.7%, with changes in consciousness and elevated serum C-reactive protein (CRP) levels identified as key factors in diagnosis.
- Analysis of 27 isolated strains found that they were mostly susceptible to common antibiotics, but only 22.2% were responsive to trimethoprim-sulfamethoxazole, indicating potential treatment challenges.
- Genetic testing revealed a variety of sequence types and clonal complexes among the strains, with the predominance of specific genotypes, highlighting the need for vigilance in monitoring the spread of these virulent strains.
Article Synopsis
- Dehydration priming (DP) creates a form of stress memory that enhances plants' abilities to adapt to future dehydration and salt stresses, but the specific molecular mechanisms behind this process remain unclear.
- This study focused on identifying proteins, their phosphorylation levels, and metabolic pathways involved in DP-induced tolerance to dehydration and salt in the grass species Agrostis stolonifera.
- Findings revealed that DP affects various proteins and phosphorylation sites differently under dehydration and salt conditions, highlighting distinct metabolic pathways and post-translational modifications that contribute to the plant's stress adaptability.