Artemordosins A-L, cadinane-monoterpene heterodimers and sesquiterpenoids with antihepatoma activity from Artemisia ordosica.

Two unprecedented sesquiterpene and monoterpene heterodimers and ten previously undescribed sesquiterpenoids, artemordosins A-L (1-12), as well as ten known sesquiterpenoids (13-22), were obtained from Artemisia ordosica. Their structures were elucidated based on comprehensive analyses of NMR, IR, HRESIMS, GIAO NMR calculations with DP4+ probability analysis, and ECD calculations. Notably, artemordosins A and B (1 and 2) were the first examples of cadinane-monoterpene dimers, and artemordosin A (1) was a cadinane-myrceane heterodimer with a 6/6/6/6 ring system formed by [4 + 2] cycloaddition, while artemordosin B (2) was a 4,5-seco-cadinane-artemisane dimer connected through a C-5-O-C-4' linkage.

Minimally invasive treatment of grade I and II gluteal muscle contracture using a self-made special cutter combined with a specialized compression hemostasis device.

Background: To explore the method and curative effect of minimally invasive treatment of gluteal muscle contracture (GMC) with self-made special cutter combined with special compression hemostasis device.

Methods: The data of 88 patients with GMC treated in our hospital from May 2017 to January 2021 were analyzed retrospectively. They were divided into two groups according to different surgical instruments and hemostatic devices.

[Ginsenoside Rg_1 modulates ATP5A1 deacetylation via SIRT3 to attenuate hypoxia/reoxygenation injury in HL-1 cardiomyocytes].

This study investigated the mechanism by which ginsenoside Rg_(1 )attenuates hypoxia/reoxygenation(H/R) injury in HL-1 cardiomyocytes by inhibiting the acetylation of ATP synthase subunit alpha(ATP5A1) through silent information regulator 3(SIRT3). In this study, an H/R injury model was constructed by hypoxia for 6 h and reoxygenation for 2 h in HL-1 cardiomyocytes. First, the optimal effective concentration of ginsenoside Rg_1 was determined using a cell viability assay kit.

Investigation of the interaction between collagen and furan derivatives during the heating process via multidimensional spectroscopy and GC-MS technology.

The flavor retention plays a critical role in the presence of rich flavor profile of meat products. However, the interaction between collagen and furan derivatives has not been previously reported. In this study, the interaction between collagen and furan derivatives during heating was investigated using multidimensional spectroscopy and gas chromatography-mass spectrometry (GC-MS).

Epidemiological Characteristics of Falls from the National Injury Surveillance System - China, 2019-2022.

Introduction: This study describes and analyzes the distribution of fall cases documented in the National Injury Surveillance System (NISS) from 2019 to 2022.

Methods: Fall data from the NISS (2019-2022) were descriptively analyzed by gender and age.

Results: The NISS in China reported 2,324,577 fall cases from 2019 to 2022.

Dupilumab, corticosteroids and their combination for the treatment of bullous pemphigoid.

Background: Conventional systemic corticosteroid therapy for bullous pemphigoid (BP) has been challenged due to severe adverse events. Dupilumab has emerged as an alternative therapeutical option of BP patients.

Objectives: To evaluate the efficacy of dupilumab monotherapy and the combination with medium/low-dose corticosteroids for BP treatment.

MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling.

Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) detects viral or endogenous DNA, activating the innate immune response to infections and autoimmune diseases. Upon binding to double-stranded DNA, cGAS synthesizes 2'3' cGMP-AMP, which triggers type I interferon production. Besides its presence in the cytosol and nucleus, cGAS is found at the plasma membrane, although its significance remains unclear.

3D-BCLAM: A Lightweight Neurodynamic Model for Assessing Student Learning Effectiveness.

Evaluating students' learning effectiveness is of great importance for gaining a deeper understanding of the learning process, accurately diagnosing learning barriers, and developing effective teaching strategies. Emotion, as a key factor influencing learning outcomes, provides a novel perspective for identifying cognitive states and emotional experiences. However, traditional evaluation methods suffer from one sidedness in feature extraction and high complexity in model construction, often making it difficult to fully explore the deep value of emotional data.

A Review of SiC Sensor Applications in High-Temperature and Radiation Extreme Environments.

Sensors operating in extreme environments are currently a focal point of global research. Extreme environmental conditions, such as overload, vibration, corrosion, high pressure, high temperature, and radiation, can affect the performance of sensors to the point of failure. It is noteworthy that, compared to the resistance to overload and vibration achieved through structural design, the application of sensors under high-temperature and radiation extreme conditions poses a greater challenge.

Surface Modification of Ultra-High-Molecular-Weight Polyethylene and Applications: A Review.

Ultra-high-molecular-weight polyethylene (UHMWPE) is often considered an ideal reinforcing material due to its extraordinary characteristics like high abrasion resistance, excellent toughness, and chemical stability. However, the poor surface properties have significantly hindered the progress of UHMWPE with high performance. This review is intended to introduce the physicochemical mechanisms of UHMWPE interfacial property modification.

Effect of Preimplantation Genetic Testing for Aneuploidy on Live Birth Rate in Young Women With Recurrent Implantation Failure: A Secondary Analysis of a Multicentre Randomised Trial.

Objective: To investigate the benefit of preimplantation genetic testing for aneuploidy (PGT-A) in recurrent implantation failure (RIF).

Design: Secondary analysis of a multicentre, randomised, double-blind, placebo-controlled clinical trial.

Setting: Eight academic fertility centres in China, 2018-2020.

The effect of Tai Chi on elderly depression: a systematic review and meta-analysis of randomized controlled trials.

Objective: This systematic review and meta-analysis assess the impact of Tai Chi on emotional well-being and quality of life in elderly individuals with depression.

Methods: Searching six databases until October 20, 2024, including Embase, PubMed, Cochrane Library, Web of Science, SinoMed, and CNKI, for randomized controlled trials (RCTs). Participants were aged ≥60 and diagnosed with depression.

Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review.

In recent years, probiotics, as a class of biologically active microorganisms, have increasingly attracted attention for their potential in treating neurodegenerative diseases (NDDs). To comprehensively assess the effects of probiotics on clinical symptoms and systemic inflammation regulation in various NDDs, this systematic review conducted a detailed search of the Cochrane Library, Embase, PubMed, and Web of Science databases, ultimately including 22 eligible randomized controlled trials (RCTs), with 4 RCTs for Alzheimer's Disease (AD), 10 RCTs for Parkinson's Disease (PD), 2 RCTs for Multiple Sclerosis (MS), and 2 RCTs for Mild Cognitive Impairment (MCI), and intervention durations ranging from 4 to 16 weeks. The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health.

Theoretical framework and emerging challenges of lipid metabolism in cancer.

Elevated lipid metabolism is one of hallmarks of malignant tumors. Lipids not only serve as essential structural components of biological membranes but also provide energy and substrates for the proliferation of cancer cells and tumor growth. Cancer cells meet their lipid needs by coordinating the processes of lipid absorption, synthesis, transport, storage, and catabolism.

Factors affecting the elderly's behavioral intention toward smart home systems: A cross-sectional study from China's eastern coast.

As China's population continues to age rapidly, smart elderly care has become a crucial strategy for addressing this societal challenge. Smart home systems have the potential to significantly enhance the quality of life, safety, and autonomy of the elderly. However, the adoption rate of these systems in this demographic remains relatively low, requiring an exploration of the key factors influencing the behavioral intention to use such systems.

Structures of PSI-FCPI from Thalassiosira pseudonana grown under high light provide evidence for convergent evolution and light-adaptive strategies in diatom FCPIs.

Diatoms rely on fucoxanthin chlorophyll a/c-binding proteins (FCPs) for light harvesting and energy quenching under marine environments. Here we report two cryo-electron microscopic structures of photosystem I (PSI) with either 13 or five fucoxanthin chlorophyll a/c-binding protein Is (FCPIs) at 2.78 and 3.

Comparison of Classical, Neural Network and Hybrid Models for Hysteretic Single-tendon Catheter Kinematics.

While robotic control of catheter motion can improve tip positioning accuracy, hysteresis arising from tendon friction and flexural deformation degrades kinematic modeling accuracy. In this paper, we compare the capabilities of three types of models for representing the forward and inverse kinematic maps of a clinical single-tendon cardiac catheter. Classical hysteresis models, neural networks and hybrid combinations of the two are included.

The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications.

Autophagy is a catabolic process that has been conserved throughout evolution, serving to degrade and recycle cellular components and damaged organelles. Autophagy is activated under various stress conditions, such as nutrient deprivation, viral infections, and genotoxic stress, and operates in conjunction with other stress response pathways to mitigate oxidative damage and maintain cellular homeostasis. One such pathway is the Nrf2-Keap1-ARE signaling axis, which functions as an intrinsic antioxidant defense mechanism and has been implicated in cancer chemoprevention, tumor progression, and drug resistance.

Blocking CCL3-mediated neutrophil recruitment into the brain alleviates immunopathology following severe enterovirus 71 infection.

Inflammatory cells infiltration in the cerebrospinal fluid is a hallmark of severe enterovirus 71 (EV71) infection, but which type of immune cells are critical for severe EV71 infection remains unclear. Here, we observe that both neutrophils and macrophages are increased in the brains of patients and mice with severe EV71 infection, and the depletion of neutrophils but not macrophages results in a marked enhancement of survival of EV71-infected mice. Furthermore, CCR1/3 may play an important role in CCL3 facilitating the accumulation of neutrophils in the brains of patients.

Vacancy-rich NiFe-LDH/carbon paper as a novel self-supporting electrode for the electro-Fenton degradation of polyvinyl chloride microplastics.

Electrochemically upcycling polyvinyl chloride (PVC) into high-value small molecules represents a sustainable strategy for mitigating plastic pollution. Herein, a cost-effective self-supporting electrode with abundant vacancies, i.e.

Bottom-up approaches to prepare ultrathin TiO nanosheets.

Atomically thin two-dimensional (2D) materials are promising platforms to explore the unusual physical and chemical properties in surface chemistry, various catalysis, and devices. Most 2D materials derive from inherently layer-structured compounds through top-down exfoliation, but it is usually challenging to directly prepare ultrathin nanosheets of non-layered materials. TiO contains at least 8 non-layered polymorphs, and some of them have found wide applications in heterogeneous catalysis, photocatalysis, solar cells, lithium-ion batteries, In this review, we summarize typical bottom-up wet-chemistry synthetic systems of atomically thin TiO nanosheets.