OPA3 inhibits the cGAS-STING pathway mediated by mtDNA stress to promote colorectal cancer progression.

Colorectal cancer (CRC) is an extremely harmful malignant tumor. Optic atrophy 3 (OPA3) is highly expressed in multiple tumors, but its action in CRC is still unknown. This research aims to explore the role of OPA3 and its related molecular mechanisms for CRC.

Cesium accumulation and plant growth promotion characteristics of A10 isolated from L. rhizosphere soil.

The combined microbial-plant remediation has increasingly been used to remediate heavy metal-contaminated soil. Some microorganisms could enhance phytoremediation efficiency by solubilizing heavy metal and improve plant growth by producing phytohormones in the heavy metal contaminated soils. In the present study, a strong cesium (Cs)-tolerant fungal strain was identified from soil microorganisms contaminated with Cs, and the enrichment conditions for Cs were optimized.

Behavioral and functional responses of different bird clades to offshore windfarms in yellow sea, China.

Offshore windfarms (OWFs) constitute a rapidly expanding source of renewable energy that inevitably affects marine biodiversity, especially those built within critical areas for biodiversity conservation. To understand the potential effect of OWFs on bird communities, we systematically tracked bird communities and their behavior within OWFs near the Migratory Bird Sanctuaries along the Coast of the Yellow Sea in China from 2020 to 2022 using voyage investigations. The results indicated that bird diversity was greater within OWFs than in seawaters away from the OWFs.

LncRNA HCP5 acts as a potential diagnostic biomarker and attenuates the inflammatory response in neonatal sepsis by targeting miR-138-5p/SIRT1.

Introduction: This study aimed to investigate the clinical significance and potential mechanism of long non-coding RNA human histocompatibility leukocyte antigen complex P5 (HCP5) in neonatal sepsis (NS).

Material And Methods: The study enrolled 86 patients with NS and 80 neonates with respiratory tract infection or pneumonia. The Pearson correlation coefficient was used to evaluate the association of procalcitonin (PCT), C-reactive protein (CRP), and inflammatory factors with HCP5.

Degradable Radical Polymer Cathode for Lithium Battery with Long-Term Cycling Capability.

Polymer-based organic electrodes for rechargeable batteries are attractive due to their design flexibility, sustainability, and environmental compatibility. Unfortunately, waste management of conventional polymer materials typically involves incineration, which emits greenhouse gases. Consequently, degradable polymers should be ideal candidates for future green batteries.

Optimal Definition and Risk Stratification in Prediabetes With Stable Coronary Heart Disease: A Prospective Cohort Study.

Background: The optimal definition and risk stratification approach to identify high-risk patients with prediabetes and stable coronary heart disease has not been well studied to date. The objective of the current study is to compare the prognostic value of different definitions of prediabetes, and to explore the role of "very-high-risk" (VHR) criteria according to the 2018 American Heart Association/American College of Cardiology cholesterol guideline in the risk stratification of patients with prediabetes and stable coronary heart disease.

Methods And Results: This prospective large-cohort study enrolled a total of 7930 patients with stable coronary heart disease.

Interaction effects of exposure to air pollution and social activities on cognitive function in middle-aged and older Chinese adults based on a nationwide cohort study.

Background: Although there have been many studies on the relationship between ambient air pollution and cognitive functioning in developed countries, there are no studies focusing on the interaction between ambient air pollution and social activities. This study aims to examine interactive effects of ambient air pollution and social activities on cognitive function in Chinese middle-aged and older.

Methods: This study used nationally representative longitudinal survey data of China Health and Retirement Longitudinal Study (CHARLS) 2013, 2015 and 2018.

Machine Learning and Deep Learning for Diagnosis of Lumbar Spinal Stenosis: Systematic Review and Meta-Analysis.

Background: Lumbar spinal stenosis (LSS) is a major cause of pain and disability in older individuals worldwide. Although increasing studies of traditional machine learning (TML) and deep learning (DL) were conducted in the field of diagnosing LSS and gained prominent results, the performance of these models has not been analyzed systematically.

Objective: This systematic review and meta-analysis aimed to pool the results and evaluate the heterogeneity of the current studies in using TML or DL models to diagnose LSS, thereby providing more comprehensive information for further clinical application.

Angiographic Observation of the Perforators of Thoracodorsal Artery and Application of the Perforator Flaps in Repairing Adjacent Wounds.

Objective: The thoracodorsal artery perforator flap has not been widely used in clinical practice partly due to a lack of imaging evidence. The authors aim to investigate the types of thoracic dorsal artery perforators through angiography and provide our experiences in the utilization of thoracic dorsal artery perforator flaps to repair adjacent wounds.

Methods: This study was divided into two parts.

PDA/PMMA blend membrane utilized for the selective adsorption and separation of heavy metal ions.

The detrimental effects of heavy metal aqueous pollution are attracting people's attention increasingly. Membrane separation technology plays a pivotal role in the treatment of aqueous pollution due to its low energy consumption and excellent separation effect. Inspired by the strong adhesion of heavy metal ions by the dopamine in mussel protein, we have fabricated the 5%, 10%, 20% and 30% proportion of polydopamine (PDA)/Polymethyl methacrylate (PMMA) blend membranes with dopamine structure by solvent-induced phase conversion.

Head-mounted Devices for Low Vision: A Review.

Head-mounted devices (HMDs) are wearable electronic tools designed to augment the visual experience of low-vision patients who have a decrease in vision not improved by refractive correction. They do so by addressing various principles of visual enhancement, including magnification, illumination, increased field of view, and contrast sensitivity enhancement, among others. Since the introduction of the first HMD 3 decades ago, advancements in technology have made these devices more lightweight and practical for everyday use.

pH/HO dual-responsive macrophage-targeted chitosaccharides nanoparticles to combat intracellular bacterial infection.

Antibiotic resistance combined with bacteria internalization result in recurrent infections that seriously threaten human health. To overcome these problems, a pH/HO dual-responsive nanoparticle (COSBN@CFS@PS) that can target macrophages, exhibiting synergistic antibiotic and β-lactamase inhibitor activity, is reported. Chitosaccharides (COS) is covalently bound with benzenboronic acid pinacol ester and assemble with cefoxitin sodium salt (CFS) to form COSBN@CFS nanoparticles.

Regulating tumor cells to awaken T cell antitumor function and enhance melanoma immunotherapy.

Tumor cells transmit various immunosuppressive signals and induce a dysfunctional state in T cells, which essentially leads to immune escape and tumor progression. However, developing effective strategies to counteract the domestication of T cells by tumor cells remains a challenge. Here, we prepared pH-responsive lipid nanoparticles (NL/PLDs) co-loaded with PCSK9 shRNA, lonidamine (LND), and low-dose doxorubicin (DOX).

Brain derived β-interferon is a potential player in Alzheimer's disease pathogenesis and cognitive impairment.

Background: Recent research has postulated that the activation of cGAS-STING-interferon signalling pathways could be implicated in the pathogenesis of Alzheimer's disease (AD). However, the precise types of interferons and related cytokines, both from the brain and periphery, responsible for cognitive impairment in patients with AD remain unclear.

Methods: A total of 131 participants (78 [59.

Relationship between circulating miRNA-222-3p and miRNA-136-5p and the efficacy of docetaxel chemotherapy in metastatic castration-resistant prostate cancer patients.

Background: Metastatic castration-resistant prostate cancer is the most dangerous stage of prostate cancer, with a high mortality rate. Docetaxel chemotherapy is one of the most effective treatment methods currently, but some patients do not respond to chemotherapy. To avoid unnecessary toxicity in non-responders, this study explores the potential of circulating microRNAs as early biomarkers of docetaxel response in patients with metastatic castration-resistant prostate cancer.

Cold plasma and honey synergistically inhibit polyphenol oxidase to enhance fresh-cut apple preservation.

Fresh-cut apple slices (FAS) are prone to browning and microbiological safety issues. This study investigated the synergistic effects of cold plasma (CP) treatment and honey coating (HC) on preserving FAS quality during storage. Among six honeys, 10 % jujube honey exhibited the strongest anti-browning effect.

Enhanced electron transfer for the improvement of nitrogen removal efficiency and NO reduction at low temperatures.

Low temperature generally restricts biological activity, slowing down electron transfer in biogeochemical cycles and causing a series of environmental problems such as nitrogen pollution. We present a strategy to boost electron transfer in microbial cell at low temperatures via stimulation with low current. It is demonstrated by establishing a constructed wetland system coupled with solar powered microbial electrolysis cell, which enhances microbial activity through external micro currents (18.

A wearable triboelectric impedance tomography system for noninvasive and dynamic imaging of biological tissues.

Tissue imaging is usually captured by hospital-based nuclear magnetic resonance. Here, we present a wearable triboelectric impedance tomography (TIT) system for noninvasive imaging of various biological tissues. The imaging mechanism relies on the obtained impedance information from the different soft human tissues.

The mediating effects of mobile phone use on ADHD and educational outcomes: a two-step Mendelian randomisation study.

Objective: This study investigates the potential mediating role of mobile phone screen time in the causal relationships between Attention-deficit/hyperactivity disorder (ADHD) and educational attainment. Our analysis explores both the effect of ADHD on educational outcomes and the reverse, i.e.

Monocyte to high-density lipoprotein cholesterol ratio as a predictor of the activity of thyroid-associated ophthalmopathy.

Aim: To evaluate the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and the disease activity of thyroid-associated ophthalmopathy (TAO).

Methods: A total of 87 patients were classified into two groups based on clinical activity score (CAS) scoring criteria: high CAS group (=62, the CAS score was ≥3); low CAS group (=25, the CAS score was <3). In addition, a group of healthy people (=114) were included to compared the MHR.

Difference in fecal and oral microbiota between pancreatic cancer and benign/low-grade malignant tumor patients.

Background: Significant gaps exist in understanding the gastrointestinal microbiota in patients with pancreatic cancer (PCA) versus benign or low-grade malignant pancreatic tumors (NPCA). This study aimed to analyze these microbiota characteristics and explore their potential use in distinguishing malignant pancreatic lesions.

Methods: Between September 2020 and May 2024, fecal and oral samples were collected from 121 patients undergoing surgical resection or diagnostic biopsy of pancreatic lesions, including 75 patients with PCA and 46 patients with NPCA, and 16s rRNA sequencing was performed.

Global burden of low vision and blindness due to age-related macular degeneration from 1990 to 2021 and projections for 2050.

Background: Age-related macular degeneration (AMD) is a leading cause of blindness and low vision worldwide. This study examines the global burden and trends in AMD-related low vision and blindness from 1990 to 2021, with projections through 2050.

Methods: Data were obtained from the 2021 Global Burden of Disease (GBD 2021) study, covering 204 countries and regions.

A genetically encoded fluorescent whole-cell biosensor for real-time detecting estrogenic activities in water samples.

Real-time monitoring of estrogenic activity in the aquatic environment is a challenging task. Current biosensors face difficulties due to their limited response speed and environmental tolerance, especially for detecting wastewater, the major source of estrogenic compounds in aquatic environments. To address these difficulties, this study developed a single fluorescent protein (FP) -based whole-cell bacterial biosensor named ER-Light, which was achieved by inserting the sensing domain of the estrogen receptor (ER) into the FP Citrine and expressing it in the periplasm of Escherichia coli.