Gram-Scale Preparation of Tri-Coordinated Single-Atom Catalysts for CO Electrolysis in Large-Scale Membrane Electrode Assembly.

Accelerating the commercialization of CO electroreduction is essential for carbon utilization, yet it faces challenges of precious metal catalysts cost and scaling-up of the corresponding devices. In this study, a low-cost and tri-coordinated single-atom catalyst (SAC) with Ni-N3 center is fabricated in gram-scale using metal ionic liquids as precursor. The gram-scale Ni-N3 SAC (g-NiN3) achieves efficient electroreduction of CO to CO (eCO-to-CO) with a maximum Faradaic efficiency of 98.

Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.

Unlabelled: Light scattering in biological tissue presents a significant challenge for deep imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely absorbing dye molecules, which created transparency in the red spectrum while blocking shorter-wavelength photons. In this paper, we extend this capability to achieve optical transparency across the entire visible spectrum by employing molecules with strong absorption in the ultraviolet spectrum and sharp absorption edges that rapidly decline upon entering the visible spectrum.

Urban-Rural Disparities in Depressive Symptoms Among Employed Individual: Education Plays an Important Role.

Objective: Focusing on the relationship between education level and the occurrence of depressive symptoms, the purpose of this study was to investigate the factors influencing urban-rural differences in depressive symptoms among employed Chinese workers and to measure the contribution of relevant influencing factors.

Measurements: This study utilized the nationally representative resampled data from the China Family Panel Studies (CFPS) in 2018. A binary logistic regression model was established to explore the major factors influencing depressive symptoms among employed individuals.

Dual-species biofilm and other profiles altered by interactions between Salmonella Typhimurium and Pseudomonas fluorescens isolated from meat.

Salmonella Typhimurium is a significant foodborne pathogen that poses substantial health risks to humans. Pseudomonas fluorescens is a key bacterium responsible for meat deterioration through the production of spoilage-associated enzymes. Both species are widely presented in meat, and can form dense biofilms on slaughterhouse equipment surfaces, acting as persistent sources of bacterial contamination that compromise both safety and quality issues in the meat industry.

TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.

Members of the tripartite motif (TRIM)-containing protein family play crucial roles in regulating immune system responses. The TRIM38 protein regulates host innate immunity and directly degrades some viral proteins through its E3 ubiquitin ligase activity. This study demonstrated that Zika virus (ZIKV) infection can promote the expression of TRIM38 in human glioma cells (U251).

κ-Carrageenan from Grateloupia filicina protects against PM-induced intraocular pressure elevation.

This study investigates the efficacy of GFP01, an almost pure κ-carrageenan derived from Grateloupia filicina, in counteracting intraocular pressure (IOP) elevation induced by PM exposure. GFP01, characterized by a molecular weight of 97.8 kDa, exhibits a linear backbone composed of 4-O-sulfated-β-D-galactose and 3,6-anhydro-α-D-galactose.

Constraining an Unconstrained Multi-agent Policy with offline data.

Real-world multi-agent decision-making systems often have to satisfy some constraints, such as harmfulness, economics, etc., spurring the emergence of Constrained Multi-Agent Reinforcement Learning (CMARL). Existing studies of CMARL mainly focus on training a constrained policy in an online manner, that is, not only maximizing cumulative rewards but also not violating constraints.

miR-372-3p represses hepatic stellate cell activation via the RhoC/ROCK pathway.

The study was undertaken to determine the mechanism of miR-372-3p activating hepatic stellate cell (HSC). Transforming growth factor-β1 (TGF-β1) induced LX-2 cells were transfected with miR-372-3p mimics and/or RhoC overexpression vector (oe-RhoC), after which the miR-372-3 and RhoC expressions were detected and the biological functions of transfected cells were assessed. The relation between miR-372-3p and RhoC predicted online was validated using the dual-luciferase assay.

ACE-Breast-02: a randomized phase III trial of ARX788 versus lapatinib plus capecitabine for HER2-positive advanced breast cancer.

This phase III trial aimed to compare ARX788, a site-specific, construct-homogeneous antibody-drug conjugate, with lapatinib plus capecitabine in patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer (ABC) who had progressed on one line of trastuzumab based regimen. Eligible patients were randomized (1:1) to receive ARX788 (1.5 mg/kg, IV, Q3W) or lapatinib plus capecitabine (LC: lapatinib 1250 mg QD; capecitabine 1000 mg/m BID, days 1-14, Q3W) and stratified by prior chemotherapy lines (0-1 versus >1) and visceral metastasis (yes versus no).

Unraveling the ecological interactions between dairy strains Bacillus licheniformis and Bacillus cereus during the dual-species biofilm formation.

Bacillus cereus and Bacillus licheniformis are widely presented in dairy products. They can form thick biofilms on surfaces of dairy processing equipment, which may pose serious safety issues and spoilage of final dairy products. However, how ecological interactions between B.

Design of CoQ crops based on evolutionary history.

Coenzyme Q (CoQ) is essential for energy production by mitochondrial respiration, and it is a supplement most often used to promote cardiovascular health. Humans make CoQ, but cereals and some vegetable/fruit crops synthesize CoQ with a side chain of nine isoprene units. Engineering CoQ production in crops would benefit human health, but this is hindered by the fact that the specific residues of the enzyme Coq1 that control chain length are unknown.

Demonstration of fully ion-implanted SiC UV phototransistors with enhanced performance in the far-UVC band.

In this work, a 4H-SiC phototransistor based on an ion implantation process is demonstrated. The incorporation of a surface pn-junction structure effectively enhances the overall device responsivity, particularly in the far-UVC band, where responsivities of 100.7 A/W at 200 nm and 60.

Association between deformity angular distance ratio and neurological risk in patients undergoing three-column osteotomy.

Objective: Postoperative neurological deficits are a significant concern for surgeons during spinal deformity correction surgery. Preoperative identification of high-risk patients can help ensure that appropriate measures are taken to minimize the risk of neurological deficits during these procedures. Previous studies have shown that patients with large Cobb angles or deformity angular ratios (DARs) are at higher risk for postoperative neurological deficits.

Simulation of the electrolyte imbalance in vanadium redox flow batteries.

The stack is the core component of large-scale flow battery system. Based on the leakage circuit, mass and energy conservation, electrochemicals reaction in porous electrode, and also the effect of electric field on vanadium ion cross permeation in membrane, a model of kilowatt vanadium flow battery stack was established. The electro chemical reaction parameters, ion concentration and temperature of each single cell in the stack were calculated respectively.

Toward a Cohort Perspective of Climate Epidemiology: The Case of Examining Intergenerational Inequalities in Susceptibility to Non-Optimal Temperatures in Japan.

Background: Younger generations are projected to experience more severe climate exposure impacts during their lifetimes than older generations as global warming progresses. Despite the increasing evidence of the recent temporal changes in heat-related mortality risks, there remains a lack of research exploring this association from a cohort perspective.

Objective: Our objective was to quantify the variation in susceptibility to short-term effects of non-optimal temperature on mortality, across generations and over the life course of specific generations, using a novel age-period-cohort approach.

Short-term exposure to desert dust and sandstorms and all-cause and cause-specific mortality and morbidity: A systematic review and meta-analysis.

Background: Desert dust and sandstorms raise concerns about their adverse effects on human health. Over the last decade, special attention has been given to mineral dust particles from desert sand. However, evidence from previous literature reviews has yielded inconclusive results regarding their health effects.

Correlations between spinopelvic parameters and health-related quality of life in degenerative lumbar scoliosis patients before and after long -level fusion surgery.

Background: For degenerative lumbar scoliosis (DLS), prior studies mainly focused on the preoperative relationship between spinopelvic parameters and health-related quality of life (HRQoL), lacking an exhaustive evaluation of the postoperative situation. Therefore, the postoperative parameters most closely bonded with clinical outcomes has not yet been well-defined in DLS patients. The objective of this study was to comprehensively assess the correlation between radiographic parameters and HRQoL before and after surgery, and to identified the most valuable spinopelvic parameters for postoperative curative effect.

The value of metagenomic next-generation sequencing in the diagnosis of fever of unknown origin.

Fever of unknown origin (FUO) caused by infection is a disease state characterized by complex pathogens and remains a diagnostic dilemma. Metagenomic next-generation sequencing (mNGS) technology is a promising diagnostic tool for identifying pathogenic microbes of FUO caused by infection. Little is known about the clinical impact of mNGS in the etiological diagnosis of FUO.

A scoping review and thematic analysis of the effects of tropical cyclones on diarrheal diseases.

Background: Tropical cyclones pose significant health risks and can trigger outbreaks of diarrheal diseases in affected populations. Although the effects of individual hazards, such as rainfall and flooding, on diarrheal diseases are well-documented, the complex multihazard nature of tropical cyclones is less thoroughly explored. To date, no dedicated review comprehensively examines the current evidence and research on the association between tropical cyclones and diarrheal diseases.

Control of in Seafood Using the Combination of Lytic Phages and Citric Acid.

is a key foodborne pathogen in seafood that poses health risks to consumers. The application of phages and organic acids is considered an alternative strategy for controlling bacterial contamination in foods. In the present study, the genome features of five previously isolated virulent phages (VPpYZU64, VPpYZU68, VPpYZU81, VPpYZU92, and VPpYZU110) were characterized, and their bacteriostatic effects in combination with citric acid were analyzed.

Microplastics in the surface waters of the northern South China Sea: Interannual variation and potential ecological risks.

Microplastic pollution in marine environments has become a global concern due to its potential ecological risks. However, long-term data on microplastic distribution are scare, hindering the assessment of the ecological threats. This study monitored microplastics pollution in the surface water of the northern South China Sea from 2019 to 2023.

Developing and validating an Interdisciplinary Teaching Readiness Scale (ITRS) for pre-service teachers in China.

Assisting pre-service teachers in developing readiness for interdisciplinary teaching has been recognized as a crucial direction in teacher education in China. However, there is currently a lack of reliable instrument to measure the readiness. We developed and validated an Interdisciplinary Teaching Readiness Scale (ITRS) for pre-service teachers to fill the gap.

Depressive symptoms among the oldest-old in China: a study on rural-urban differences.

Background: In China, In China, depression among the oldest-old (aged 80 + years) is a major public health issue. As the gap in development between urban and rural China widens, the aim of this study was to demonstrated whether there are disparities in the incidence of depressive symptoms between the urban and rural oldest-old (aged 80+) in China and to quantify the contribution of relevant influencing factors.

Methods: The study evaluated data on 5,116 oldest adults (female, 55.

Enhancing translational medical research through proof-of-concept services: clinicians' perspectives.

Although the proof-of-concept (POC) phase is critical for the success of translational medical research (TMR), its use remains limited, and clinicians are frequently uncertain about how to seek assistance from POC teams when experiencing difficulties with TMR. Therefore, this study explored clinicians' awareness of POC and the supportive reference services offered by POC teams. We distributed an internet-based questionnaire to 702 clinicians who conducted TMR between August 2022 and March 2023.

Bioinformatics Analysis of Biomarkers and Therapeutic Targets Related to Necroptosis in Intervertebral Disc Degeneration.

Necroptosis is a critical process in intervertebral disc degeneration (IDD). This research is aimed at identifying key genes regulating necroptosis in IDD to provide a theoretical basis for early diagnosis and treatment. Transcriptome data from patients with IDD and normal samples were obtained from the GSE34095 and GSE124272 datasets of the Gene Expression Omnibus (GEO) public database.