Publications by authors named "Yuan Jiao Gao"
Article Synopsis
- The study aimed to investigate the clinical characteristics and cytokine levels in patients with drug-induced liver injury (DILI) from various drug categories, assessing how these factors correlate with clinical indicators.
- A total of 73 patients were categorized based on the type of drug causing DILI, revealing significant differences in liver enzyme levels between groups, particularly higher alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in NSAIDs users compared to those using Chinese herbal medicines.
- The findings suggest older patients are more susceptible to DILI, and higher levels of inflammation markers (IL-6 and TNF-α) in NSAIDs patients could be linked to more severe liver damage.
Article Synopsis
- - The study investigated the relationship between dendritic cell subsets and the decline of hepatitis B surface antigens in chronic hepatitis B patients undergoing intermittent interferon therapy.
- - It categorized patients into three groups: a natural history group, a long-term nucleoside analogs treatment group, and a plateau-arriving group, measuring dendritic cells and costimulatory molecules using flow cytometry.
- - Findings revealed that the plateau group had significantly lower levels of certain dendritic cells and costimulatory molecule expression, suggesting these reductions may be linked to the plateau phase in treatment response.
Metagenomics is a new approach to study microorganisms obtained from a specific environment by functional gene screening or sequencing analysis. Metagenomics studies focus on microbial diversity, community constitute, genetic and evolutionary relationships, functional activities, and interactions and relationships with the environment. Sequencing technologies have evolved from shotgun sequencing to high-throughput, next-generation sequencing (NGS), and third-generation sequencing (TGS).
View Article and Find Full Text PDFBackground & Aims: Nucleotides with add-on interferon treatment (NUC-IFN) provide significantly higher rates of hepatitis B surface antigen (HBsAg) loss in patients with chronic hepatitis B (CHB). This study aimed to investigate the sustainability of HBsAg loss and the prevention of clinical relapse.
Methods: Patients with CHB who achieved HBsAg loss and HBV DNA levels <20 IU/ml after IFN or NUC-IFN therapy were enrolled and followed up for 96 weeks.
Liver necroinflammation is the indicator for treating patients with chronic hepatitis B (CHB) infection. However, there is no suitable non-invasive index for diagnosing liver necroinflammation. This study aimed to create a non-invasive index to predict liver necroinflammation in patients who lack clear-cut clinical inflammation parameters.
View Article and Find Full Text PDFHepatitis B surface antigen (HBsAg) loss is considered a functional cure in chronic hepatitis B (CHB). However, the durability of HBsAg loss after stopping treatment remains unknown. This study aimed to assess the sustained functional cure achieved by interferon therapy in hepatitis B envelope antigen (HBeAg)-negative CHB patients.
View Article and Find Full Text PDF[Study on effect of intensive treatment for refractory chronic hepatitis C patients].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
October 2012
Objective: To explore the effect of intensive treatment for refractory chronic hepatitis C, and to improve the sustained viral response (SVR) rate of treatment with interferon plus ribavirin by optimizing therapeutic dose and course.
Methods: Patients who did not acquire response or partial response by standard therapy (PEG-IFN alpha subcutaneous injection weekly plus Ribavirin 10.5 mg/kg) every day were enrolled and retreated with intensive treatment of 10 MU interferon every other day or 360 microg pegylated interferon alpha-2a weekly according to patients' wishes, and ribavirin 15 mg/kg every day.