Publications by authors named "Yuan Hui Li"

Being able to quickly and accurately detect and recognize target balls is a key task for basketball robots in automated and intelligent sports competitions. This study aims to propose an effective target detection method for basketball robots, which is based on the improved YOLOv5s model and introduces spatial pyramid pooling and instance-batch normalization structure. The study first pre-trained the model and compared the migration training with the random initialization approach.

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Since ancient times, traditional Chinese medicine pills have occupied a key position among different dosage forms of traditional Chinese medicine. With the aims of comprehensively improving the overall quality and innovating key technologies in the manufacturing of the pills, this article elaborates on the principles and new technology applications in pulverizing, sterilization, agglomeration, forming, and drying. In addition, modern technologies such as biosensing, image analysis, texture property evaluation, and moisture analysis can comprehensively and accurately characterize the quality of key materials in the manufacturing of traditional Chinese medicine pills, thereby achieving strict control over the quality of raw materials, intermediates, and final products and further monitoring and optimizing the entire production process of pill preparations.

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Article Synopsis
  • * Solid preparations, the primary form of TCM drugs, require complex manufacturing processes and strict quality control, leading enterprises to revamp their methods for better quality and efficiency.
  • * This paper reviews recent policies and studies on TCM manufacturing, discussing the challenges and trends in intelligent manufacturing, aiming to support future research and development in the field.
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  • The study investigates how synthetic MRI techniques, specifically Syn T2-FLAIR and Syn double inversion recovery (DIR), compare to conventional T2-FLAIR in detecting white matter hyperintensities (WMHs) in young migraine patients.
  • An analysis of MRI data from 50 patients showed that Syn methods provide clearer images and detect more lesions, particularly in deep and juxtacortical regions, compared to conventional techniques.
  • The findings suggest that using Syn T2-FLAIR and Syn DIR can enhance the identification of WMHs, which could improve the understanding and treatment of migraines in young patients.
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Drying is an indispensable processing step for Chinese medicinal materials after harvesting. It often leads to significant changes in the active components of these materials, thus impacting their medicinal values. Understanding the mechanisms behind the changes during the drying process is of great importance for regulating the transformation of key active components.

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  • Spray drying is a popular method used to make traditional Chinese medicine (TCM) because it dries quickly and keeps the product quality uniform.
  • However, TCM extracts can be tricky to work with, causing problems like sticking to surfaces and clumping together during the spray drying process.
  • Researchers are now using a new technique that studies the drying of single droplets to better understand and improve the spray drying method for TCM, which could lead to faster and more effective production.
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Background: Hemophilia A is a rare inherited bleeding disorder caused by mutations in the factor VIII gene. This clotting factor plays an intrinsic role in the blood coagulation pathway. Patients with hemophilia may develop orthopedic manifestations such as hemarthrosis, but multiple malunion of fractures over the knee is rare and difficult to treat.

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Macrophages originating from the yolk sac or bone marrow play essential roles in tissue homeostasis and disease. Bone marrow-derived monocytes differentiate into Ly6C and Ly6C macrophages according to the differential expression of the surface marker protein Ly6C. Ly6C and Ly6C cells possess diverse functions and transcriptional profiles and can accelerate the disease process or support tissue repair and reconstruction.

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Article Synopsis
  • - The study investigated the effectiveness of a new spiral vibration drying technology on various Chinese medicinal pills and compared it to traditional methods like hot air and vacuum drying.
  • - Results showed that the spiral vibration drying significantly reduced the drying time to 80 minutes, saving about 10%-13% in energy consumption, and improved the uniformity and quality of the drying process.
  • - This innovation is believed to enhance the drying efficiency and manufacturing capacity of Chinese medicinal pills, potentially influencing future developments in medicinal product drying technologies.
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Background: This study analyzed the effects of ankle arthroplasty on the recovery of motor function in patients with orthopedic ankle injury.

Methods: English databases including PubMed, Web of Science, Embase, and the Cochrane Library were searched for randomized controlled trials (RCTs) examining the effects of ankle arthroplasty, ankle replacement, and joint prosthesis on motor function recovery in patients with orthopedic ankle injury. The outcome indicators included the American Orthopedic Foot and Ankle Society (AOFAS) score, the 36-item short form survey (SF-36) score, the Foot and Ankle Ability Measures (FAAM) score, and the visual analog scale (VAS) score.

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  • The study focused on understanding how environmental factors affect Vibrio vulnificus, a harmful pathogen, in the warm waters of Hawaii's Ala Wai Canal over a year.
  • The abundance of the pathogen varied significantly based on salinity levels, showing that it thrives best in moderate salinities, particularly between 7 to 22 ppt, and less during the summer dry season.
  • Rainfall plays a crucial role in controlling the pathogen's abundance, with higher concentrations observed during wet periods when groundwater influences the canal's salinity and nutrient levels.
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Mesenchymal stem cell (MSC) therapy has become a promising treatment for liver fibrosis due to its predominant immunomodulatory performance in hepatic stellate cell inhibition and fibrosis resolution. However, the cellular and molecular mechanisms underlying these processes remain limited. In the present study, we provide insights into the functional role of bone marrow-derived MSCs (BM-MSCs) in alleviating liver fibrosis by targeting intrahepatic Ly6C and Ly6C macrophage subsets in a mouse model.

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Purpose: To investigate the effects of different surface treatments and adhesive self-etch functional monomers on the immediate repair bond strength and integrity of the repaired resin composite interface.

Methods: Ninety-eight resin composite blocks made of a nanohybrid resin composite were randomly divided into seven groups, each with 14 blocks, including positive control group: non-conditioned surface, Group A1: Gluma Comfort Bond, Group A2: Gluma Comfort Bond and sandblasting, Group B1: Tokuyama Bond Force IITM adhesive system, Group B2: Tokuyama Bond Force IITM adhesive system and sandblasting, Group C: polishing, and Group D: sandblasting. Resin composite identical to the substrate was applied and the repaired specimens were subjected to shear bond strength (SBS) testing.

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Drying is one of the most common unit operations in the production of traditional Chinese medicine. The drying process of traditional Chinese medicine materials is accompanied by the dynamic reduction of water content. As a key index to determine the end of the drying process, the moisture content of materials plays an important role in improving drying efficiency and saving energy.

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Essential oils are easy to cause oxidative damage, chemical transformation or polymerization, and have some intrinsic problems, such as instability, low water solubility and low bioavailability, which restrict their application in the fields of product development. Nanostructured lipid carriers(NLCs) can overcome some of the restrictions of other colloidal carriers, such as emulsions, liposomes, polymer nanoparticles and solid lipid nanoparticles. NLC is an efficient and stable delivery system for bioactive substances.

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  • Dry granulation technology streamlines the granulation process by minimizing intermediate steps and costs, relying heavily on material characteristics and specialized equipment.
  • Despite its success in various industries like food and chemicals, research on applying this technology to traditional Chinese medicine remains underdeveloped.
  • The advantages of dry granulation in traditional Chinese medicine include a simplified process that maintains quality, producing granules that are crucial for the manufacturing of solid preparations and ultimately affect the product's quality.
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  • Innovative infrared-steam blanching (ISB) was found to effectively inactivate peroxidase (POD) in L. flowers with better retention of phenolics, carotenoids, and flavonoids compared to traditional steam blanching (SB) and infrared blanching (IB).
  • The study revealed that ISB allowed lower POD activity levels and produced brighter color in the flowers while preventing regeneration of POD during storage.
  • Overall, ISB for 90 seconds at 100°C is recommended as an effective blanching method for preserving the quality of natural plant products.
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Objective: To explore the efficacy of moxibustion combined with medication in the treatment of refractory nausea and vomiting and quality of life (QOL) in advanced cancer patients.

Methods: A total of 266 advanced cancer patients with nausea and vomiting were randomly assigned to Metoclopramide group (M group, =70), Metoclopramide plus Haloperidol group (MH group, =65), moxibustion + M group (=63), and moxibustion + MH group (=68). Moxibustion was applied to bilateral Zusanli (ST 36), and Guanyuan (CV 4), Qihai (CV 6) for 20 min every time, twice a day for 2 weeks.

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  • The study examined how long-term glucocorticoid (GC) treatment affects the structure of two types of bone in the femoral head of sheep.
  • Eighteen female sheep were divided into three groups: one received GC treatment for 7 months, one received the same treatment followed by 3 months without it, and a control group had no treatment.
  • Results showed that GC treatment significantly harmed the cancellous bone structure but had little effect on cortical bone; many cancellous bone properties recovered after the treatment stopped, whereas cortical thickness remained unchanged.
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  • The study analyzed six cases of rhino-orbital endoscopic surgeries using the Fusion electromagnetic system to assess the efficacy of image-guided techniques.
  • Key metrics recorded included preparation time for navigation (average 8.13 mins), surgical accuracy (within 1 mm), and outcomes, which showed no serious complications.
  • Findings suggest that this technique enhances accuracy and safety in microinvasive surgeries, but emphasizes that it cannot replace a surgeon’s expertise and anatomical knowledge.
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  • The paper focuses on the importance of compressibility in the formation of traditional Chinese medicine tablets, highlighting it as a complex process.
  • It reviews methods for evaluating tablet quality and discusses how factors like material powder properties, excipients, and preparation technology impact the overall quality of these tablets.
  • Additionally, it analyzes common issues in the tablet formation process to offer insights for improving the quality of traditional Chinese medicine tablets.
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The dry quality of traditional Chinese medicine pills is the hot spot of pills research, because their quality has a crucial effect on the efficacy and development of dosage forms. Through literature research and statistical analysis, we would review the current problems on the drying of traditional Chinese medicine pills in this paper, and surrounding the evaluation system for traditional Chinese medicine pills, analyze the characteristics of common drying equipment and processes as well as their effect on quality of pills, discuss the problems in drying equipment and process as well as quality, and put forward the corresponding strategies, hoping to provide new ideas and new methods for the quality improvement of traditional Chinese medicine pills and quality standards.

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Objective: To find the largest screw path in the acetabular anterior column using a novel method of axial perspective and test the clinical feasibility of the anterior column axial view projection.

Methods: 3D models with the inner triangular patches deleted were created from the pelvic CT scan data of 58 normal pelvises. The transparency of each 3D model was downgraded at the axial perspective (the view perpendicular to the cross section of the anterior column axis) so that a translucent area was seen clearly.

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Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc).

Aims: To study if tenuigenin (TEN), the main active component of Polygala tenuifolia, can protect dopaminergic neurons from inflammation-mediated damage in vivo.

Methods: We observed the effects of TEN on lipopolysaccharide (LPS) induced PD model by behavioral analysis, high-performance liquid chromatography, immunohistochemistry and enzyme-linked immunoadsorbent assay, etc.

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The present study was carried out to investigate the effects of exogenously applied 24-epibrassinolide (BR) on growth, gas exchange, chlorophyll fluorescence characteristics, lipid peroxidation and antioxidant systems of tomato seedlings grown under different levels (0, 10, 30, 100 and 300μM) of phenanthrene (PHE) and pyrene (PYR) in hydroponics. A concentration-dependent decrease in growth, photosynthetic pigment contents, net photosynthetic rate (Pn), stomatal conductance (Gs), maximal quantum yield of PSII (Fv/Fm), effective quantum yield of PSII (Φ(PSII)), photochemical quenching coefficient (qP) has been observed following PHE and PYR exposure. By contrast, non-photochemical quenching coefficient (NPQ) was increased.

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