Comparison of noninvasive electrical cardiometry and transpulmonary thermodilution for cardiac output measurement in critically ill patients: a prospective observational study.

Background: Cardiac output (CO) monitoring is essential for diagnosing and managing critically ill patients. Recently, a non-invasive haemodynamic monitoring technique, electrical cardiometry (EC), has gathered increasing interest among ICU physicians. This study aimed to explore the accuracy of CO estimated by non-invasive EC (CO) compared to CO determined by transpulmonary thermodilution (CO) and to evaluate the ability of CO to track CO changes (ΔCO).

The impact of proactive personality and needs-supplies fit on the career success of pediatric healthcare workers.

Background: Career success is crucial for both individuals and organizations. Even though career success is considered an individual result, it depends on the organization's success and can contribute to its success. This study uses proactive personality and needs-supplies fit as independent variables to explore the potential relationship between proactive personality and needs-supplies fit and the career success of pediatric healthcare workers.

Role of iron in brain development, aging, and neurodegenerative diseases.

It is now understood that iron crosses the blood-brain barrier a complex metabolic regulatory network and participates in diverse critical biological processes within the central nervous system, including oxygen transport, energy metabolism, and the synthesis and catabolism of myelin and neurotransmitters. During brain development, iron is distributed throughout the brain, playing a pivotal role in key processes such as neuronal development, myelination, and neurotransmitter synthesis. In physiological aging, iron can selectively accumulate in specific brain regions, impacting cognitive function and leading to intracellular redox imbalance, mitochondrial dysfunction, and lipid peroxidation, thereby accelerating aging and associated pathologies.

Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy.

The shared HLA-bound neoepitopes in pancreatic ductal adenocarcinoma (PDAC) represent a novel class of non-canonical antigens with single amino acid substitutions, resulting from translational errors. These peptides, shared across PDAC patients, showed higher immunogenicity than wild-type counterparts, offering potential candidates for specific immunotherapy development in PDAC.

Comparative analysis of chemical constituents in the stems and roots of different Ephedra species and their in vitro anti-acute lung injury effects.

Ephedra, the sole genus in the Ephedraceae family, comprises 75 species distributed across Asia, North America, and South America. Ephedrae herba, a well-established traditional Chinese medicine, has been used in clinical practice for over two millennia. Ephedra is widely used to treat asthma, colds, and coughs.

To accurately predict lymph node metastasis in patients with mass-forming intrahepatic cholangiocarcinoma by using CT radiomics features of tumor habitat subregions.

Background: This study aims to introduce the concept of habitat subregions and construct an accurate prediction model by analyzing refined medical images, to predict lymph node metastasis (LNM) in patients with intrahepatic cholangiocarcinoma (ICC) before surgery, and to provide personalized support for clinical decision-making.

Methods: Clinical, radiological, and pathological data from ICC patients were retrospectively collected. Using information from the arterial and venous phases of multisequence CT images, tumor habitat subregions were delineated through the K-means clustering algorithm.

The Anterior Mandibular Alveolar Bone Augmentation With Sticky Bone in Periodontally Accelerated Osteogenic Orthodontics.

Objective: Sticky bone, a composite of porcine-derived xenograft bone material and serum components obtained from autologous blood centrifugation, was implanted into the anterior mandibular alveolar bone during periodontally accelerated osteogenic orthodontics (PAOO) in a patient with skeletal Class III malocclusion. The augmentation and stability of the alveolar bone in the grafted area were evaluated over a one-year follow-up period.

Methods: A patient with skeletal Class III malocclusion underwent PAOO surgery as part of presurgical orthodontic treatment.

Physical Activity, Positive Coping, and Psychological Distress Among People Living with HIV/AIDS in Henan, China: A Moderated Mediation Analysis.

This study aims to investigate the mediating role of positive coping in the relationship between physical activity and psychological distress (PD) among people living with HIV/AIDS (PLWHA) in Henan, China, and to explore the moderating factor regarding this relationship. A cross-sectional study was conducted among 517 PLWHA, recruited from four cities in Henan province. Path analysis was employed to examine the mediating effect of positive coping in the link between physical activity and PD.

Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data.

High-dimensional multiplexed imaging can reveal the spatial organization of tumour tissues at the molecular level. However, owing to the scale and information complexity of the imaging data, it is challenging to discover and thoroughly characterize the heterogeneity of tumour microenvironments. Here we show that self-supervised representation learning on data from imaging mass cytometry can be leveraged to distinguish morphological differences in tumour microenvironments and to precisely characterize distinct microenvironment signatures.

A robust spider-silk-like calcium alginate fiber with biomineralized rough spindle-knots for water collection.

The hydrophilic spindle-knot microfiber serves as a valuable tool for water collection to combat freshwater scarcity. However, balancing microfiber's water collection efficiency and reusability remains a challenge. To address this contradiction, a microfluidic approach utilizing enzyme-mediated, in situ biomineralization is developed to produce biomineralized rough spindle-knot calcium alginate microfibers (BSMs).

Comparison of Tubridge and Pipeline Embolisation Devices in intracranial aneurysms: a multicentre, propensity-matching analysis on the patency of branch vessels.

To compare the impact of two flow diverter devices (Pipeline Embolization Device [PED] and Tubridge Embolization Device [TED]) on branch vessels patency in intracranial aneurysm treatment, with specific focus on branch vessel outcomes and clinical safety. A retrospective analysis of 320 patients with 430 aneurysms and 602 covered branches treated with PED or TED was conducted. Statistical analyses included descriptive statistics and group comparisons.

Establishing rabbit critical-size bone defects to evaluate the bone-regeneration potential of porous calcium phosphate ceramics.

Critical-size bone defects (CSDs), which are those that do not self-repair in a given period, are essential for evaluating bone-regeneration strategies. We established CSDs models in the rabbit cranium and ulna, and the bone-regeneration capacities of porous calcium phosphate (CaP) ceramics were assessed. A 12.

Exonic CircGUCY1A2 inhibits pulmonary artery smooth muscle cells phenotypic switching via regulating O-glycosylation of COL3A1 in pulmonary hypertension.

Pulmonary hypertension (PH) is a fatal disease characterized by pulmonary vascular remodeling, whose regulatory mechanisms remain unclear. Circular RNAs (circRNAs) are a unique class of RNA molecules produced by covalent linkages via back-splicing of linear RNA and play vital roles in regulating physiological and pathological processes. However, the dysregulation of circRNAs and their underlying mechanisms in PH remain unclear.

Estimation of Species Abundance Based on the Number of Segregating Sites Using Environmental DNA (eDNA).

The advance of environmental DNA (eDNA) has enabled rapid and non-invasive species detection in aquatic environments. While most studies focus on species detection, recent works explored using eDNA concentration to quantify species abundance. However, the differential individual DNA contribution to eDNA samples could easily obscure the eDNA concentration-species abundance relationship.

Exploring the biological mechanism and clinical value of perineural invasion in pancreatic cancer.

Pancreatic cancer (PC) is an extremely aggressive malignancy, with a 5-year survival rate of only 13 %. Perineural invasion (PNI) is a hallmark pathological feature of PC and is observed in almost all cases. Accordingly, PC ranks highly among solid tumors in terms of PNI incidence.

Analysis of the effect of platelet function and different doses of ticagrelor after flow diverter treatment of intracranial aneurysms.

Ticagrelor has become the standard drug for the treatment of intracranial aneurysms (IAs) with flow diverters (FDs), but the dosage has not been standardized. The effect of platelet function on clinical and imaging prognosis remains unclear. This study aimed to show the effects of different doses of ticagrelor and platelet aggregation function on the clinical and imaging prognosis after FDs treatment of aneurysms.

Starch retrogradation in starch-based foods: Mechanisms, influencing factors, and mitigation strategies.

Starch-based foods are the most common foods in the daily diets. However, starch-based foods are prone to starch retrogradation, resulting in texture hardening, taste deterioration and nutrient loss. This paper reviewed the mechanisms and the influencing factors of starch retrogradation in starch-based foods, and the strategies to mitigate it.

Depression-related innate immune genes and pan-cancer gene analysis and validation.

Background: Depression, a prevalent chronic mental disorder, presents complexities and treatment challenges that drive researchers to seek new, precise therapeutic targets. Additionally, the potential connection between depression and cancer has garnered significant attention.

Methods: This study analyzed depression-related gene expression data from the GEO database.

Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus).

Background: The relict gull (Larus relictus, Charadriiformes, Laridae) classified as vulnerable in the IUCN Red List is defined as a first-class national protected bird in China. However, our knowledge of the evolutionary history of L. relictus is limited.

Downregulation of N6-methyladenosine (m6A) methylation of Sema4D mRNA contributes to Treg dysfunction and allograft rejection.

Regulatory T cells (Tregs) have been shown to be involved in the induction of transplantation tolerance in numerous models. Our previous work demonstrated that methyltransferase-like 14 (METTL14) loss impaired Treg function and hindered the establishment of transplantation tolerance. However, the underlying mechanisms remain unclear.

Cross-sectional and longitudinal association of sleep patterns and aneurysmal vulnerability biomarkers on high-resolution magnetic resonance vessel wall imaging.

Background: Aneurysm wall enhancement (AWE) on vessel wall imaging (VWI) scans is a robust biomarker for aneurysmal vulnerability. This study aimed to explore the association of different sleep patterns with AWE and other vulnerability features.

Methods: Patients with unruptured intracranial aneurysms were prospectively recruited.

Premelted-Substrate-Promoted Selective Etching Strategy Realizing CVD Growth of High-Quality Graphene on Dielectric Substrates.

Direct chemical vapor deposition growth of high-quality graphene on dielectric substrates is a great challenge. Graphene growth on dielectrics always suffers from the issues of a high nucleation density and poor quality. Herein, a premelted-substrate-promoted selective etching (PSE) strategy was proposed.

High quantum yield copper nanoclusters integrated with nitrogen-doped carbon dots for off-on ratiometric fluorescence sensing of S and Zn.

Pursuing nanomaterials with high fluorescence quantum yields is of great significance in the fields of bioimaging, medical diagnosis, and food safety monitoring. This work reports on orange-emitting aggregation-induced emission (AIE) copper nanoclusters (Cu NCs) integrated with blue-emitting nitrogen-doped carbon dots (N-CDs), which enables highly sensitive detection of S and Zn ions through an off-on ratiometric fluorescence method. The highly emissive Cu NCs was doped by Ce with a high quantum yield of 51.

Comparison of the efficacy and safety of Landiolol and Esmolol in critically ill patients: a propensity score-matched study.

Background: Excessive tachycardia is associated with impaired hemodynamics and worse outcome in critically ill patients. Previous studies suggested beneficial effect of β-blockers administration in ICU patients, including those with septic shock. However, comparisons in ICU settings are lacking.