Association of intratumoral microbiome diversity with hepatocellular carcinoma prognosis.

The evidence that intratumoral microbiomes, as a rising hallmark of cancer, have a profound impact on cancer phenotypes is increasingly compelling. However, the impact of the composition and diversity of the intratumoral microbiome on the prognosis of patients undergoing surgical resection for hepatocellular carcinoma (HCC) remains incompletely understood. In this study, we revealed a high abundance of bacteria in the neoplastic tissues.

Differences in PCV13 Recommendation Practices between Pediatric Care Providers and Primary Care Providers in China: A Cross-Sectional Survey of Behavior and Social Drivers.

This study examines the recommendation behaviors and influencing factors for the 13-valent Pneumococcal Conjugate Vaccine (PCV13) among 3579 Chinese healthcare workers (HCWs), including 1775 pediatric care providers (Peds-PCPs) and 1804 primary care providers (PCPs). Data were collected from May to July 2023 through a national cross-sectional survey using a structured questionnaire, distributed across hospitals providing pediatric services in five provincial-level administrative divisions. The sociodemographic data, vaccine knowledge, and recommendation practices were analyzed using Pearson's chi-square test, Wilcoxson rank-sum test, and multivariate logistic regression.

HNF1ɑ promotes colorectal cancer progression via HKDC1-mediated activation of AKT/AMPK signaling pathway.

The hepatocyte nuclear factor-1 (HNF1ɑ) is a transcription factor that contributes to several kinds of cancer progression. However, very little is known regarding the mechanisms underlying the activity of HNF1ɑ. We aimed to explore the role of HNF1ɑ in the progress of colorectal cancer (CRC) and elucidate its molecular mechanism.

Investigation of the association between the Toll-like receptor 1 rs4833095 variation and gastric adenocarcinoma recurrence.

Background: Toll-like receptors (TLRs) are a family of transmembrane receptors that play key roles in identifying invading pathogens and activating innate immunity. TLR1 has been reported to be associated with the risk of gastric cancer (GC) but that was based on only a simple statistical analysis.

Methods: We genotyped the TLR1 in 526 GC patients to investigate the association between the variation and gastric cancer survival by the multiplex polymerase chain reaction and sequencing method.

Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1α/METTL16/lnc-CSMD1-7/RBFOX2 axis.

Hypoxic microenvironment is clinically associated with metastasis and poor prognosis of numerous cancers. The mechanisms by which intratumoral hypoxia regulates metastasis are not fully understood. Our study identifies a downregulation of Lnc-CSMD1-7 in hepatocellular carcinoma (HCC) and correlated with poor prognosis of HCC patients.

A novel bimetallic organic framework catalyst induced by dual-ligand for highly efficient oxygen evolution.

With the continuous advancement of non-noble electrocatalysts, metal-organic frameworks (MOFs) are emerging as a promising substitute for noble metal nanomaterials in oxygen evolution reaction (OER) due to their larger pre-development and higher cost-effectiveness. However, there are still challenges in modifying the electronic structure of MOFs at the molecular level to enhance their activity of OER. Herein, bimetallic CoNi MOFs were utilized and modified with terephthalic acid (A) and 2, 5-dihydroxyterephthalic acid (B) (AB-CoNi MOFs) through a straightforward hydrothermal method.

The Effects of a High-Fat Diet on Inflammatory Bowel Disease.

The interactions among diet, intestinal immunity, and microbiota are complex and play contradictory roles in inflammatory bowel disease (IBD). An increasing number of studies has shed light on this field. The intestinal immune balance is disrupted by a high-fat diet (HFD) in several ways, such as impairing the intestinal barrier, influencing immune cells, and altering the gut microbiota.

NiO-NiMoO Nanocomposites on Multi-Walled Carbon Nanotubes as Efficient Bifunctional Electrocatalysts for Total Water Splitting.

Multicomponent synergistic regulation and defect design have been effective strategies to enhance the electrocatalytic activity of transition-metal oxides. In this work, NiO and NiMoO nanocomposites on multi-walled carbon nanotubes (termed NiO-NiMoO/mCNTs) are synthesized through a two-step method. Physical characterizations show NiO-NiMoO/mCNTs have a well-defined NiO-NiMoO structure, large specific surface area, and abundant oxygen vacancies.

Does Education Influence Life-Course Depression in Middle-Aged and Elderly in China? Evidence from the China Health and Retirement Longitudinal Study (CHARLS).

Mental health problems have become a major public health problem worldwide and are more common among middle-aged and elderly people in China. Research on the effect of education on depression is limited, and whether the relationship between education and depression changes over the life course remains unclear. This study was based on the cross-sectional data of 15,767 middle-aged and elderly individuals in the 2018 tracking survey (Wave 4) of the China Health and Retirement Longitudinal Study (CHARLS) database.

A self-circulating electro-fenton-like process over FeO-CaO cathode for highly efficient degradation of levofloxacin.

Electro-Fenton reaction was limited by the generation of HO and the circulation of Fe(Ⅱ)/Fe(Ⅲ). Herein, an efficient electro-Fenton-like process was constructed based on FeO-CaO cathode promoted by peroxymonosulfate (PMS). Levofloxacin (LEV) could be efficiently degraded (92.

Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China.

Background: combination vaccines can improve timely vaccination coverage and mitigate the social and economic burdens of both caregivers and health systems. Compared to other countries with high immunization performance, China remains behind the curve in promoting the inclusion of new combination vaccines into national vaccination schedules. The domestic research and development pipeline faces many technical obstacles, regulatory pressures, and competitive opposition.

An Ultrasensitive Electrochemical Biosensor Integrated by Nicking Endonuclease-Assisted Primer Exchange Reaction Cascade Amplification and DNA Nanosphere-Mediated Electrochemical Signal-Enhanced System for MicroRNA Detection.

Specific and sensitive microRNAs (miRNAs) detection is essential to early cancer diagnosis. The development of these technologies including functional nuclease-mediated target amplification and DNA nanotechnology possesses tremendous potential for the high-performance detection of miRNAs in the accurate diagnosis of disease. In this study, we have established an ultrasensitive electrochemical biosensor by combining nicking endonuclease-assisted primer exchange reaction (PER) cascade amplification with a DNA nanosphere (DNS)-mediated electrochemical signal-enhanced system for the detection of miRNA-21 (miR-21).

A carbon dots-enhanced laccase-based electrochemical sensor for highly sensitive detection of dopamine in human serum.

Enzyme-based electrochemical sensor possesses a significant advantage in the highly efficient detection of small molecules, however, the poor electron transport efficiency limits their wide application. In this study, taking advantage of the distinct biocatalytic activity of laccase and the excellent electroconductibility of carbon dots, a carbon dots-enhanced laccase-based electrochemical sensor for the detection of dopamine (DA) is established. Thereinto, laccase can specifically recognize DA and promote its electrocatalytic oxidation on the electrode, while, the carbon dots can be used as the immobilization substrate of laccase and enhance its electron transfer efficiency, thus achieving the highly sensitive detection of dopamine.

A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model.

An inappropriate diet is a risk factor for inflammatory bowel disease (IBD). It is established that the consumption of spicy food containing capsaicin is strongly associated with the recurrence and worsening of IBD symptoms. Moreover, capsaicin can induce neutrophil accumulation in the lamina propria, contributing to disease deterioration.

Rapid fabrication of bionic pyrogallol-based self-adhesive hydrogel with mechanically tunable, self-healing, antibacterial, wound healing, and hemostatic properties.

Hydrogels are functional materials that are similar to human skin and have received much attention in recent years for biomedical applications. However, the preparation of nontoxic, highly adhesive, and antimicrobial hydrogels in an efficient way remains a great challenge. Inspired by adhesive mussel foot proteins (mfps) which consist of abundant catecholic amino acids and lysine (Lys) residues, gallic acid-modified ε-poly-L-lysine (EPL/GA) was synthesized, and an active functional monomer (AA-EPL/GA) was then created through a reaction with acrylic acid (AA).

Clinical and functional characterisation of the SMAD4 germline variant c.1035C > A in a family with juvenile polyposis syndrome by whole-exome sequencing.

Juvenile polyposis syndrome (JPS) is a rare autosomal dominant inherited disease characterised by multiple juvenile polyps. Genes with JPS-associated mutations and their correlation with the phenotype are currently unknown. Gastrointestinal endoscopy results of a 31-year-old female patient showed multiple polyps in the digestive tract, and the presence of juvenile polyps was confirmed by pathological examination.

Enterogenous Microbiotic Markers in the Differential Diagnosis of Crohn's Disease and Intestinal Tuberculosis.

Crohn's disease (CD) is a chronic intestinal disorder characterized by refractory gastrointestinal ulcerations. Intestinal tuberculosis (ITB) is one common intestinal disease in east Asia. The two diseases share similar clinical manifestations and endoscopic characteristics.

Tannic acid reinforced electro-Fenton system based on GO-FeO/NF cathode for the efficient catalytic degradation of PNP.

In order to overcome the sluggish kinetics of the redox conversion between Fe and Fe in Fenton process, we established a novel electro-Fenton system based on GO-FeO cathode and tannic acid (TA) for the efficient degradation of p-nitrophenol (PNP). Under the optimal degradation parameters (including the initial PNP concentration of 20 mg L, pH = 5, current density of 30 mA cm and feeding ratio of PNP: TA = 1:2), the TA reinforced GO-FeO electro-Fenton system exhibited the removal rate of PNP over 90.1 ± 0.

Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers.

Colorectal adenocarcinoma (COAD) is one subtype of colorectal carcinoma (CRC), whose development is associated with genetics, inappropriate immune response, and environmental factors. Although significant advances have been made in the treatment of COAD, the mortality rate remains high. It is a pressing need to explore novel therapeutic targets of COAD.

A novel electrochemically enhanced homogeneous PMS-heterogeneous CoFeO synergistic catalysis for the efficient removal of levofloxacin.

A novel electrochemically enhanced homogeneous-heterogeneous catalytic system was constructed by placing the prepared heterogeneous catalyst (CoFeO/NF) in parallel between the anode and the cathode for peroxymonosulfate (PMS) activation to remove levofloxacin (LVF) in this work. Over 90% of LVF could be effectively removed by the constructed system after 40 min's degradation. And the electrical energy consumption was only 2.

LncRNA AFAP1-AS1 Modulates the Proliferation and Invasion of Gastric Cancer Cells by Regulating AFAP1 via miR-205-5p.

Purpose: The present study investigated the expression and function of the long noncoding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) related to gastric cancer (GC), based on previous results from a microarray analysis.

Methods: Real-time quantitative polymerase chain reaction (qPCR) was used to verify the expression of AFAP1-AS1 in 97 fresh GC tissues and paired non-GC tissues, as well as in six different GC cell lines (BGC-823, SGC-7901, MGC-803, AGS, MKN-45, and MKN-28). The expression levels were subsequently correlated with the clinicopathological features of patients.

Tendon-inspired fibers from liquid crystalline collagen as the pre-oriented bioink.

Nature provides rich bionic resources for the construction of advanced materials with excellent mechanical properties. In this work, inspired by animal tendons, a bionic collagen fiber was developed using collagen liquid crystals as the pre-oriented bioink. The texture of liquid crystalline collagen observed from polarized optical microscopy (POM) showed the specific molecular pre-orientation.

Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan.

Collagen (COL)-chitosan (CS) composite hydrogels are attracting increasing attention because of their great potential for application as biomaterials. However, conventional COL-CS hydrogels were easily disabled for lack of fully reversible linking in their networks. In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.