Publications by authors named "Yuan Chen Wang"
Objectives: Associations of ABO blood group specifying transferases A/B (ABO) and fucosyltransferase 2 (FUT2) with CP remain inconclusive. We aimed to comprehensively investigate the associations by Chinese sequencing cohorts and external cohorts.
Methods: First, we analyzed the distributions of ABO blood groups and FUT2 status, along with lead single nucleotide polymorphisms (SNPs) at ABO (rs8176693 C/T) and FUT2 (rs632111 A/G) gene loci in Chinese low-coverage whole-genome sequencing discovery cohort.
Comparison of the efficacy and safety of basket catheters and balloon catheters for endoscopic pancreatic duct stone clearance.
Hepatobiliary Pancreat Dis Int
November 2024
Article Synopsis
- A study compared the effectiveness and safety of basket versus balloon catheters for removing pancreatic duct stones during ERCP in patients with chronic pancreatitis.
- Results showed similar overall stone clearance rates for both catheters (around 86%), but the balloon catheter performed better for larger stones (≥ 2 cm).
- No significant differences in adverse event rates, pain relief, or quality of life were found between the two catheter groups after one year of follow-up.
Effect of Infection on the Incidence of Hyperglycemic Hemichorea: A Case-Series.
Diabetes Metab Syndr Obes
September 2024
Objective: To explore the effect of infection on hyperglycemic hemichorea.
Methods: The clinical data of 11 patients with hyperglycemic hemichorea admitted to the Affiliated People' s Hospital of Xinxiang Medical College and the Second People's Hospital of Xinxiang were retrospectively analyzed, including gender, age, clinical symptoms, imaging features, blood glucose, glycated hemoglobin, infection indicators, and treatment conditions.
Results: Eleven patients had acute or sub-acute onset, including 9 females and 2 males, with an average age of 74.
Article Synopsis
- The mechanical properties of Ti65 alloy, crucial for high-temperature aero-engine components, are impacted by long-term thermal exposure between 450 °C and 650 °C, influencing its safety in service.
- Testing revealed that the strength of the Ti65 alloy initially rises with temperature but eventually decreases, while ductility consistently declines.
- Factors such as surface oxidation, the size and amount of the phase, and silicides significantly affect the alloy's mechanical behavior, leading to increased stress concentration and reduced ductility, resulting in cracks and premature failures.
Chronic pancreatitis (CP) is a complex disease with genetic and environmental factors at play. Through trio exome sequencing, a de novo SEC16A frameshift variant in a Chinese teenage CP patient is identified. Subsequent targeted next-generation sequencing of the SEC16A gene in 1,061 Chinese CP patients and 1,196 controls reveals a higher allele frequency of rare nonsynonymous SEC16A variants in patients (4.
View Article and Find Full Text PDFArticle Synopsis
- Researchers are studying a way to help people with chronic pancreatitis (CP), which currently has no cure.
- They used a special virus (AAV8) to deliver a treatment directly to the pancreas in mice, which helped lessen symptoms and speed up recovery from the disease.
- The results showed that this treatment was safe and worked well, making it a hopeful option for stopping or treating CP in the future.
Genetic Factors Associated With Adverse Pregnancy Outcomes in Chronic Pancreatitis.
Clin Transl Gastroenterol
April 2024
Article Synopsis
- A study was conducted to understand how genetic factors and clinical features affect pregnancy outcomes in Chinese women with chronic pancreatitis (CP), focusing on specific gene mutations (SPINK1, PRSS1, CTRC, CFTR).
- Out of 160 female CP patients, 59.4% had pathogenic gene mutations, showing that those with mutations experienced higher rates of adverse pregnancy outcomes such as preterm delivery and abortion compared to those without mutations.
- The research concluded that mutations in CP-susceptibility genes, particularly in SPINK1, are significant risk factors for adverse pregnancy outcomes, highlighting the need for careful monitoring of affected patients during pregnancy.
Article Synopsis
- PRSS1 is a gene linked to chronic pancreatitis, and its variants can be difficult to classify due to differences in their effects on the enzyme's function.
- The study analyzed 100 variants of the PRSS1 gene, categorizing them based on genetic impact and clinical significance using a new classification system.
- Findings indicate that many PRSS1 variants can be classified as pathogenic, likely pathogenic, or benign, which could help improve how these variants are reported in medical databases.
Article Synopsis
- Chronic pancreatitis (CP) significantly diminishes the quality of life for patients, leading to the development of the Pancreatitis Quality of Life Instrument (PANQOLI) to assess their QoL.
- A Chinese version of PANQOLI was created through careful translation and testing with 500 Mandarin-speaking CP patients, ensuring reliability and validity through various analyses.
- The final results indicated that the Chinese PANQOLI exhibits excellent reliability and validity, making it an effective tool for evaluating the quality of life in Chinese-speaking patients with chronic pancreatitis.
A novel capsule endoscopy for upper and mid-GI tract: the UMGI capsule.
BMC Gastroenterol
March 2023
Article Synopsis
- Researchers developed a new type of upper and mid gastrointestinal capsule endoscopy using a modified magnetic control method to improve observation of the GI tract.
- *In a study with 30 patients, the system achieved high detection rates for key areas in the GI tract and had a complete examination rate of 95.45%.
- *The capsule endoscopy was well received by patients with minimal discomfort, no adverse events, and a high diagnostic yield, suggesting its potential for use in detecting GI bleeding.
Article Synopsis
- A systematic review was conducted to understand how different types and durations of exercise affect the quality of life (QoL) in survivors of digestive system cancer (DSC).
- The review included 32 studies with 2558 participants, finding that short-term aerobic exercise significantly improved general health, mental health, and role functioning, while resistance exercise showed potential benefits for physical health and fatigue.
- Additionally, short-term aerobic exercise was linked to reductions in insomnia, depression, and anxiety, as well as shorter hospital stays for patients, though long-term resistance exercise effects were less clear.
Background And Aims: Heavy alcohol consumption and genetic factors represent the 2 major etiologies of chronic pancreatitis (CP). However, little is so far known about the clinical features and genetic basis of light-to-moderate alcohol consumption-related CP (LMA-CP).
Methods: A cross-sectional analysis was performed on 1061 Chinese CP patients between 2010 and 2015.
Article Synopsis
- This study focuses on the safety and effectiveness of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in older patients (over 65) with chronic pancreatitis, contrasting it with younger patients.
- The results showed that the success rates of ERCP were comparable between the elderly and younger groups, but older patients experienced a higher rate of moderate to severe complications.
- Specific factors like being female and having conditions like pancreas divisum were linked to an increased risk of post-ERCP pancreatitis in geriatric patients.
Background: The lesions of certain diseases are widely distributed in both stomach and small intestine, while the step-by-step strategy of gastroscopy followed by enteroscopy can be burdensome and costly. We aimed to determine if magnetically controlled capsule endoscopy (MCE) could be used in one-time gastro-small intestine (GSI) joint examination.
Methods: In this study, data of patients in Chinese PLA General Hospital and Changhai Hospital who underwent MCE GSI examination from January 2020 to August 2021 were retrospectively analysed.
The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in Mice.
Cell Mol Gastroenterol Hepatol
June 2022
Background & Aims: A hybrid allele that originated from homologous recombination between CEL and its pseudogene (CELP), CEL-HYB1 increases the risk of chronic pancreatitis (CP). Although suggested to cause digestive enzyme misfolding, definitive in vivo evidence for this postulate has been lacking.
Methods: CRISPR-Cas9 was used to generate humanized mice harboring the CEL-HYB1 allele on a C57BL/6J background.
Article Synopsis
- FXR is identified as an inhibitor of platelet function and promotes the production of antithrombin III (AT III), which is crucial in regulating blood coagulation.
- In experiments with both normal and FXR knockout mice, activating FXR led to prolonged clotting times and decreased levels of key coagulation factors, while FXR knockout reversed these effects.
- The findings indicate that FXR enhances the expression of AT III in the liver, suggesting its potential as a therapeutic target for conditions involving excessive blood clotting.
Objective: The carboxyl-ester lipase (CEL) gene contains a variable number of tandem repeats (VNTR) region. It remains unclear whether the number of repeats in the CEL VNTR is related to the risk of pancreatic diseases. The aim of this study was to investigate whether CEL VNTR length is associated with idiopathic chronic pancreatitis (ICP), alcoholic chronic pancreatitis (ACP), or pancreatic cancer in a cohort of Chinese patients.
View Article and Find Full Text PDFBackground And Aims: Actual behaviors of drugs in the upper GI tract are not well elucidated. We assess the feasibility of magnetically controlled capsule endoscopy (MCE) in direct and real-time visualization of oral drug behaviors in the stomach.
Methods: From November 2019 to December 2019, 9 patients with a recent history of upper GI symptoms and 10 healthy volunteers were enrolled in this study.
Background And Aims: The high incidence of osteopathy among patients with chronic pancreatitis (CP) has garnered increased attention over recent years. The aims of this study were to assess the prevalence and risk factors for osteopathy in Chinese patients with CP.
Methods: This was a cross-sectional study of CP patients from a large center in China; patients were recruited between 31 January 2017 and 31 January 2018.
Background: A full spectrum of video capsule endoscopy (VCE) adverse events over the past two decades has not been evaluated. We aimed to determine pooled rates, predictors and temporal-trend of VCE adverse events over the past two decades.
Methods: Systematic search of PubMed and EMBASE for English-language publications reporting VCE adverse events (January 1, 2000 to March 31, 2019).
Objectives: Sinistral portal hypertension (SPH) is an uncommon complication of chronic pancreatitis (CP) and can result in severe gastrointestinal bleeding. The aim of this study was to determine the prevalence and the potential risk factors for SPH and related gastrointestinal variceal bleeding in patients with CP.
Methods: We retrospectively reviewed all patients with SPH due to CP admitted to our hospital from July 2014 to June 2019 in this case-control study.
Background And Aims: Magnetically controlled capsule endoscopy (MCE) has become an efficient diagnostic modality for gastric diseases. We developed a novel automatic gastric lesion detection system to assist in diagnosis and reduce inter-physician variations. This study aimed to evaluate the diagnostic capability of the computer-aided detection system for MCE images.
View Article and Find Full Text PDFChronic pancreatitis (CP) is a progressive fibroinflammatory syndrome of the pancreatic tissue caused by genetic and environmental factors. Previously reported susceptibility genes in CP explain less than half of the apparent heritability. To uncover novel pathogenic mechanisms, we initially performed low-coverage whole-genome sequencing on 464 Chinese CP patients and 504 controls.
View Article and Find Full Text PDFThe maintenance of human pregnancy and the initiation of parturition are closely related with the dynamic balance of the maternal-fetal immune microenvironment. Implantation of the blastocyst into the maternal decidua is the first step in pregnancy establishment, which is favored by the abundant blood flow and the immunotolerant microenvironment maintained by the balance of immune cells. The parturition resembles an inflammatory response that includes secretion of cytokines by resident and infiltrating immune cells into reproductive tissues and the maternal-fetal interface, which promotes the delivery of fetus from maternal organism.
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