Identification, distribution and ultramorphology of the larvae of Gynaephora menyuanensis (Lepidoptera: Lymantriinae) endemic to Qinghai-Tibet plateau.

The grassland caterpillar is a significant pest of alpine meadows on the Qinghai-Tibet Plateau. Its larvae primarily feed on forage grasses, resulting in financial losses. However, limited research has been done on the morphological features of larvae of this species thus far.

Instar determination, development, and sexual dimorphism for Gynaephora menyuanensis (Lepidoptera: Lymantriinae) and ultrastructure of adult antennae.

Gynaephora menyuanensis Yan & Zhou is one of the most devastating pests that harm the ecosystem of alpine meadows and hinder the advancement of animal husbandry. However, the current knowledge of the morphology of the different developmental stages within G. menyuanensis reveals an information deficit that needs to be addressed.

Age-related abnormalities in brain functional and molecular neuroimaging signatures in first-episode depression.

Abnormalities in resting-state brain activity have been demonstrated in depression patients with different ages, yet the age-related changes in dynamics of brain activity in depression are still limited. Here, we investigated the impacts of age on dynamics of brain activity and the molecular architecture. Resting-state functional magnetic resonance images were obtained from 138 first-episode depression patients and 120 healthy volunteers.

Characteristics of 3D-Integrated GaN Power Module Under Multi Heat Source Coupling.

3D-integrated GaN power modules can effectively reduce parasitic parameters and enhance the power system's performance. However, the heat from each power chip during operation can lead to a mutual thermal coupling effect, potentially causing performance drift of the GaN power chips. This work investigates the impact of the thermal coupling effect in a 3D-integrated GaN power module on the characteristics of its GaN power chips.

Callus Culture System from Anthers: Light Quality Effects on Callus Quality Evaluation.

Thunb has significant edible and medicinal value, possessing heat clearing, detoxification, antibacterial, and blood pressure reduction properties. Currently, its quality is constrained by factors such as climate, environment, flowering period, and germplasm degradation. The strategy of using bioreactors and abiotic inducers to produce bioactive metabolites has not yet been implemented.

Pharmacokinetics and pharmacodynamics of insulin lispro 25 versus the original preparation (Humalog25) in Chinese healthy male volunteers.

There are approximately 537 million adults with diabetes worldwide, and insulin still plays an important role in its treatment. However, the long-term use of insulin imposes a significant financial burden on patients. This study aims to explore the pharmacokinetic (PK)/ pharmacodynamic (PD) parameters of generic premixed insulin lispro 25 (25% insulin lispro and 75% protamine zinc lispro) and evaluate the bio-equivalence between generic and brand-name preparations to reduce medical costs while ensuring the effectiveness and safety of treatment.

Major depressive disorder on a neuromorphic continuum.

The heterogeneity of major depressive disorder (MDD) has hindered clinical translation and neuromarker identification. Biotyping facilitates solving the problems of heterogeneity, by dissecting MDD patients into discrete subgroups. However, interindividual variations suggest that depression may be conceptualized as a "continuum," rather than as a "category.

Preparation of economical and reusable novel multi-chemically modified lignin-based adsorbent for efficient adsorption of lead ions.

In this work, through sequential demethylation, amination and esterification, a novel multi-chemically modified lignin-based adsorbent (NMCL) was developed to remove lead ions (Pb) from wastewater. These modifications significantly enhanced lignin's reactivity and introduced diverse active sites, thereby improving its adsorption performances. The adsorption studies revealed that NMCL's adsorption followed the Langmuir isotherm model and Pseudo-second-order kinetics, confirming a monolayer chemical adsorption process.

A bio-based Janus hydrogel from cellulose and lignin with bilayer structure and asymmetric adhesion for accurate and sensitive human motion monitoring.

Janus hydrogels for human motion monitoring are thriving due to their conductivity, flexibility, anisotropy and self-adhesion, etc. However, most of them face challenges such as complex processes, interlayer detachment, and surface contamination, which degrade their sensing accuracy and sensitivity. Hence, this study proposes a facile strategy using the cellulose and lignin as building blocks to construct a Janus hydrogel for accurate and sensitive sensing.

Having a monk in the family and all-cause mortality: a seven-year prospective cohort study.

Religious celibate monks at the household level possibly reduce all-cause mortality risk among non-monk older Tibetans. This study aims to investigate the association between having a celibate monk in a family and the all-cause mortality of non-monk household members in a Tibetan population. Baseline interviews were conducted for 713 agropastoral Amdo Tibetans aged ≥50 years residing in the eastern Tibetan Plateau from 2016 to 2017.

Two novel SNP variants at ASIP and SNAI2 genes are associated with yellow coat color in rabbits.

Rabbits display a wide range of coat colors, with yellow being a particular phenotype that aids in exploring the molecular mechanisms of coat pigmentation. The Fujian yellow (FJY) rabbit, as China's only indigenous breed with a yellow coat, serves as a valuable genetic resource. Fujian yellow rabbits have predominantly yellow fur, with a diluted white hue on the distal limbs and tail.

Accuracy of a 3D printed custom resin crossbar for complete arch implant scanning: An in vitro and in vivo study.

Statement Of Problem: The accuracy of intraoral scanners for implant-supported prostheses in edentulous jaws is unclear with limited clinical evidence.

Purpose: The purpose of this in vitro and in vivo study was to evaluate the accuracy of a novel 3-dimensionally (3D) printed custom resin scanning crossbar (3D-CRC) for digital scans of complete arch implants and to provide a clinical benchmark.

Material And Methods: Four implants were placed on a completely edentulous master model for in vitro scanning.

A review of physiologically based pharmacokinetic modeling of renal drug disposition.

The human kidney is a critical organ for the elimination of numerous drugs and metabolites. The mechanisms of renal drug handling are manifold including unbound filtration, transporter-mediated active secretion, bidirectional passive diffusion, and occasionally active reabsorption and renal metabolism. These mechanisms collectively dictate the fate of drugs at various spatiotemporal points as drug molecules travel through the renal vasculature, tubules, and cells, posing a significant challenge in accurately describing and predicting renal drug disposition.

Ultrasound-Guided Serratus Anterior Plane Block Combined with Modified Parasternal Block in Pediatric Patients Undergoing Auricular Reconstruction Surgery Results in Superior Quality of Recovery Compared to a Standalone Serratus Anterior Plane Block.

Background: Serratus anterior plane block (SAPB) and parasternal block (PSB) are used in multimodal analgesia strategies to improve postoperative comfort and recovery. Their combined effectiveness for pediatric auricular reconstruction (AR) patients needs clarification.

Methods: A study was conducted on 100 children aged 8 to 12 undergoing autologous rib cartilage transplant in AR.

Construction of chiral crown ethers in robust covalent organic frameworks for electrochromatographic enantioseparation.

Capillary electrochromatography (CEC) is a rapidly emerging separation technique that merges the high separation efficiency of capillary electrophoresis with the exceptional selectivity of liquid chromatography. However, it remains a synthetic challenge to design functional chiral stationary phases (CSPs) with high chemical stability against acid and base in CEC enantioseparation. Here we demonstrate that incorporating chiral crown ethers into stable covalent organic frameworks (COFs) enables efficient and stable separations of racemates by CEC.

An Exploratory Comparison of Attitudes Toward Stuttering and Cluttering of Chinese Practicing Speech and Language Therapists (SLTs) and SLT Students.

This study aimed to compare attitudes toward stuttering and cluttering among speech and language therapists (SLTs) and speech and language therapy students in China and how they differ from those in other countries. It also seeks to explore factors that may influence these attitude differences. We utilized online versions of the Public Opinion Survey of Human Attributes-Stuttering (POSHA-S) and Public Opinion Survey of Human Attributes-Cluttering (POSHA-Cl) instruments to conduct surveys of 54 SLTs and 99 SLT students at six Chinese universities offering speech and language therapy programs.

Local Texture Pattern Estimation for Image Detail Super-Resolution.

In the image super-resolution (SR) field, recovering missing high-frequency textures has always been an important goal. However, deep SR networks based on pixel-level constraints tend to focus on stable edge details and cannot effectively restore random high-frequency textures. It was not until the emergence of the generative adversarial network (GAN) that GAN-based SR models achieved realistic texture restoration and quickly became the mainstream method for texture SR.

General lightweight framework for vision foundation model supporting multi-task and multi-center medical image analysis.

The foundation model, trained on extensive and diverse datasets, has shown strong performance across numerous downstream tasks. Nevertheless, its application in the medical domain is significantly hindered by issues such as data volume, heterogeneity, and privacy concerns. Therefore, we propose the Vision Foundation Model General Lightweight (VFMGL) framework, which facilitates the decentralized construction of expert clinical models for various medical tasks.

PCR array analysis reveals a novel expression profile of ferroptosis-related genes in idiopathic pulmonary fibrosis.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible, and fatal disease characterized by progressive interstitial lung fibrosis. Given its insidious onset and poor outcome, there is an urgent need to elucidate the molecular mechanisms underlying IPF and identify effective therapeutic targets and diagnosis and prognosis biomarkers. Ferroptosis is an iron-dependent form of programmed cell death that occurs as lipid peroxides accumulate.

Evaluating Drought Tolerance in Seedlings: Combining Growth, Physiology, Yield, and Tolerance Indices.

Drought stress during the (Campanulaceae) seedling stage significantly affects its growth, quality, and yield. The aim of this study was to identify drought-tolerant cultivars of by using the growth-physiology-yield composite index (GPYCI) and drought-tolerant indices. Nine cultivars were evaluated under normal-watered (black plastic film hole sowing, BF) and water-stressed (spread in the open field, SF) conditions in a design that adopted a two-factor paired experiment with three replications.

Early life imidacloprid and copper exposure affects the gut microbiome, metabolism, and learning ability of honey bees (Apis mellifera).

The pesticide imidacloprid and the heavy metal copper provide some degree of protection to plants, while at the same time causing varying degrees of damage to bees. However, few studies have investigated the negative effects of imidacloprid and copper exposure on newly emerged bees (young bees), especially when both are present in a mix. In this study, young bees were exposed to sterile sucrose solutions containing imidacloprid (10 μg/L, 100 μg/L), copper (10 mg/L, 50 mg/L), or a mix of both (10 μg/L + 10 mg/L) for 5 days to assess their gut system and behavior, with survival and dietary consumption recorded over 21 days.

Deep learning and hyperspectral features for seedling stage identification of barnyard grass in paddy field.

Barnyard grass, a pernicious weed thriving in rice fields, poses a significant challenge to agricultural productivity. Detection of barnyard grass before the four-leaf stage is critical for effective control measures. However, due to their striking visual similarity, separating them from rice seedlings at early growth stages is daunting using traditional visible light imaging models.

Retrospective study on the epidemiological characteristics of multi-pathogen infections of hospitalized severe acute respiratory tract infection and influenza-like illness in Xinjiang from January to May 2024.

Background: Acute respiratory tract infections are very common and can be caused by many pathogens. The aim of this study was to understand the characteristics of multi-pathogen infections of respiratory tract infections during the seasonal changes in winter and spring in Xinjiang.

Methods: Throat swab samples were collected from 2791 patients with influenza-like illness (ILI) and hospitalized severe acute respiratory tract infection (SARI) in Xinjiang from January 2024 to May 2024 for multi-pathogen detection.

Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and CD155/TIGIT Pathway.

Unlabelled: Pancreatic ductal adenocarcinoma (PDAC) is the deadliest major cancer and has a profoundly immunosuppressive tumor microenvironment (TME). Previous studies have shown that inhibition of the E1 enzyme, which catalyzes the small ubiquitin-like modifiers (SUMO), with the small molecule TAK-981, can reprogram the TME to enhance immune activation and suppress tumor growth. We found that the CD-155/TIGIT pathway, a key regulator of immune evasion in PDAC, is influenced by SUMOylation.