Clinical characteristics and risk factors for a prolonged length of stay of patients with asymptomatic and mild COVID-19 during the wave of Omicron from Shanghai, China.

Background: This study aims to investigate the clinical characteristics and the length of hospital stay (LOS), as well as risk factors for prolonged LOS in a cohort of asymptomatic and mild COVID-19 patients infected with the Omicron variant.

Methods: A total of 1166 COVID-19 patients discharged from the inpatient ward of the largest makeshift hospital (May 8-10, 2022) in Shanghai, China, were included. The demographics, medical history, and the lowest and admission cycle threshold (Ct) values of the RT-PCR tests for SARS-CoV-2 genes of the open reading frame 1ab (Ct-ORF) and the nucleocapsid protein (Ct-N) during hospitalization were recorded.

One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China: A Longitudinal Cohort Study.

Importance: Determining the long-term impact of COVID-19 on cognition is important to inform immediate steps in COVID-19 research and health policy.

Objective: To investigate the 1-year trajectory of cognitive changes in older COVID-19 survivors.

Design, Setting, And Participants: This cohort study recruited 3233 COVID-19 survivors 60 years and older who were discharged from 3 COVID-19-designated hospitals in Wuhan, China, from February 10 to April 10, 2020.

Post-sequelae one year after hospital discharge among older COVID-19 patients: A multi-center prospective cohort study.

Background: To systematically evaluate the prevalence of post-sequelae and chronic obstructive pulmonary disease assessment test (CAT) scoring one year after hospital discharge among older COVID-19 patients, as well as potential risk factors.

Methods: A multi-center prospective cohort study involving 1,233 eligible older COVID-19 patients was conducted. All patients were followed-up between Mar 1, 2021 and Mar 20, 2021.

Some characteristics of clinical sequelae of COVID-19 survivors from Wuhan, China: A multi-center longitudinal study.

Background: The pandemic of COVID-19 has a persistent impact on global health, yet its sequelae need to be addressed at a wide scale around the globe. This study aims to investigate the characteristics, prevalence, and risk factors for mid-term (>6 months) clinical sequelae in a cohort of COVID-19 survivors.

Methods: Totally 715 COVID-19 survivors discharged before April 1, 2020, from three medical centers in Wuhan, China, were included.

Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China.

Importance: The long-term health outcomes and symptom burden of COVID-19 remain largely unclear.

Objective: To evaluate health outcomes of COVID-19 survivors 1 year after hospital discharge and to identify associated risk factors.

Design, Setting, And Participants: This retrospective, multicenter cohort study was conducted at 2 designated hospitals, Huoshenshan Hospital and Taikang Tongji Hospital, both in Wuhan, China.

Post-infection cognitive impairments in a cohort of elderly patients with COVID-19.

Background: Understanding the long-term effects of coronavirus disease 2019 (COVID-19) on cognitive function is essential for monitoring the cognitive decline in the elderly population. This study aims to assess the current cognitive status and the longitudinal cognitive decline in elderly patients recovered from COVID-19.

Methods: This cross-sectional study recruited 1539 COVID-19 inpatients aged over 60 years who were discharged from three COVID-19-designated hospitals in Wuhan, China, from February 10 to April 10, 2020.

Hierarchical NiMoO@CoVO hybrid nanorod/nanosphere clusters as advanced electrodes for high-performance electrochemical energy storage.

Herein, a synergistic strategy to construct hierarchical NiMoO@CoVO (denoted as NMO@CVO) hybrid nanorod/nanosphere clusters is proposed for the first time, where CoVO nanospheres (denoted as CVO) have been uniformly immobilized on the surface of the NiMoO nanorods (denoted as NMO) via a facile two-step hydrothermal method. Due to the surface recombination effect between NMO and CVO, the as-prepared NMO@CVO effectively avoids the aggregation of CVO nanosphere clusters. The unique hybrid architecture can make the most of the large interfacial area and abundant active sites for storing charge, which is greatly beneficial for the rapid diffusion of electrolyte ions and fast electron transport.

The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma.

Background: Osteosarcoma is the most common primary bone malignancy in children and adolescents. In order to find factors related to its recurrence, and thus improve recovery prospects, a powerful clinical signature is needed. Long noncoding RNAs (lncRNAs) are essential in osteosarcoma processes and development, and here we report significant lncRNAs to aid in earlier diagnosis of osteosarcoma.

Zinc oxide-black phosphorus composites for ultrasensitive nitrogen dioxide sensing.

Multi-layer black phosphorus (m-BP) has been successfully incorporated in zinc oxide (ZnO) hollow spheres, thus forming hetero-structured ZnO-BP composites; a study performed on their properties reveals that the BP environmental stability can be significantly enhanced by the introduction of ZnO, and the sensors based on ZnO-BP composites exhibit high response, fast response behavior, outstanding selectivity, and ultralow detection limit of 1 ppb towards NO gas molecules. The ultrasensitive sensing performance is suggested to be due to the large surface area, excellent carrier mobility, and enhanced charge transfer of ZnO-BP in the presence of BP. Moreover, the mechanism of NO sensing with ZnO-BP is confirmed by the calculations obtained from the first-principle studies.

Enhanced Acetone Sensing Characteristics of ZnO/Graphene Composites.

ZnO/graphene (ZnO-G) hybrid composites are prepared via hydrothermal synthesis with graphite, N-methyl-pyrrolidone (NMP), and Zn(NO₃)₂·6H₂O as the precursors. The characterizations, including X-ray diffraction (XRD), thermogravimetric analyses (TGA), Raman spectroscopy, and transmission electron microscopy (TEM) indicate the formation of ZnO-G. Gas sensors were fabricated with ZnO-G composites and ZnO as sensing material, indicating that the response of the ZnO towards acetone was significantly enhanced by graphene doping.

Biodistribution and evaluation of I-labeled neuropilin-binding peptide for targeted tumor imaging.

Neuropilin-1 (NRP-1) is overexpressed in several kinds of cancer cell and contributes to tumor aggressiveness. Recently, the arginine/lysine-rich peptide with C-terminal motifs (R/K)XX(R/K) indicated promising penetrating and transporting capability into NRP-1 positive cancer cells. In the present study, we describe a I-labeled C-end rule motif peptide conjugate, Tyr-tLyp-1, for NRP-1 positive tumor targeting and imaging properties.

A novel 12, 23-epoxy dammarane saponin from Panax notoginseng.

The present study investigated the chemical constituents of the roots and rhizomes of Panax notoginseng. Compounds were isolated by various column chromatographic methods, and their structures were elucidated by the extensive analysis of spectroscopic data and chemical evidences. A novel 12, 23-epoxy dammarane-type saponin, named epoxynotoginsenoside A (1), together with four known compounds (2-5), was isolated and characterized.

A novel strategy for rapid quantification of 20(S)-protopanaxatriol and 20(S)-protopanaxadiol saponins in Panax notoginseng P. ginseng and P. quinquefolium.

A novel strategy for the qualitative and quantitative determination of 20(S)-protopanaxatriol saponins (PTS) and 20(S)-protopanaxadiol saponins (PDS) in Panax notoginseng, Panax ginseng and Panax quinquefolium, based on the overlapping peaks of main components of PTS (calibrated by ginsenoside Rg1) and PDS (calibrated by ginsenoside Rb1), was proposed. The analysis was performed by using high-performance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD). Under specific chromatographic conditions, all samples showed two overlapping peaks containing several main ginsenosides belonging to PTS and PDS, respectively.

Biological evaluation of 131I- and CF750-labeled Dmab(scFv)-Fc antibodies for xenograft imaging of CD25-positive tumors.

A Dmab(scFv)-Fc antibody containing the single chain variable fragment of a humanized daclizumab antibody and the Fc fragment of a human IgG1 antibody was produced via recombinant expression in Pichia pastoris. The Dmab(scFv)-Fc antibody forms a dimer in solution, and it specifically binds CD25-positive tumor cells and tumor tissues. For tumor imaging, the Dmab(scFv)-Fc antibody was labeled with the 131I isotope and CF750 fluorescent dye, respectively.