Publications by authors named "Yuan Biao Guo"
Article Synopsis
- * The research included 2,001 patients from 10 hospitals who underwent various treatments; findings revealed that CM significantly improved overall survival compared to standard treatments, with median survival times of 18.17 months for the CM cohort versus 12.45 months for the non-CM cohort.
- * Factors such as mixed tumor type, more than 6 cycles of first-line treatment, use of CM, palliative surgery, and specific medications were identified as independent predictors of better survival outcomes.
Background: Breast cancer is one of the most common cancers in women, affecting more than 2 million women worldwide annually. However, effective treatments for breast cancer are limited. Nobiletin is a flavonoid present in the dried mature pericarp of mandarin orange (Citrus reticulata Blanco), which is used to prepare Citri Renetulatae Pericarpium and can inhibit tumour growth and progression according to modern pharmacological studies.
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- The study aimed to analyze the types of non-typeable Haemophilus influenzae (NTHi) and changes in their resistance to β-lactam antibiotics over the past decade.
- NTHi isolates from 2013-2014 showed higher resistance levels compared to those from 2003-2004, with over half of the isolates being β-lactamase-positive and significant amino acid changes observed in key resistance genes.
- The research concluded that β-lactam-resistant NTHi strains have increased significantly and that the genetic mutations related to resistance have become more varied and complex over time.
Contactin 3 (CNTN3) is a member of the contactin family that is primarily expressed in the nervous system. However, to the best of our knowledge, expression of contactin and its role in the development and progression of brain tumours has not been studied. Although glioblastoma multiforme (GBM) is the most common malignant brain tumour, advances in therapeutic options for patients with GBM have been modest due to an incomplete understanding of the molecular mechanisms underlying development and progression.
View Article and Find Full Text PDF[Epidemiological survey of Haemophilus influenzae-positive hospitalized children: a retrospective analysis].
Zhongguo Dang Dai Er Ke Za Zhi
June 2015
Article Synopsis
- A study was conducted to analyze clinical traits and drug resistance of Haemophilus influenzae (Hi) infections in hospitalized children over two years.
- Out of 117 Hi strains isolated, the majority (91.9%) were found in respiratory infections, with higher positive rates in specific conditions like bronchopneumonia.
- There was an increase in resistance rates to certain antibiotics over the two years, indicating challenges in antibiotic treatment for Hi infections in children.
Background: Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) targeted treatment has been a standard therapy for advanced non-small cell lung cancer (NSCLC), but it is not tolerated well by all patients. In China, some studies have reported that traditional Chinese medicinal herbs (TCMHs) may increase efficacy and reduce toxicity when combined with EGFR-TKI, but outside of China few studies of this kind have been attempted.
Objective: This study is intended to systematically review the existing clinical evidence on TCMHs combined with EGFR-TKI for treatment of advanced NSCLC.
Objective: To study the effects of intraperitoneal chemotherapy (IPC) plus Shenmai Injection (SMI) in treating advanced colorectal cancer following radical resections.
Methods: Fifty-eight cases of colorectal cancer in stage B2 and C following radical resections were divided into two groups: SMI+IPC group (36 cases) and IPC group (22 cases). In the SMI+IPC group, IPC (5-fluorouracil combined with cisplatin) plus SMI was administered, while in the IPC group, only IPC was administered.
Objective: To investigate enhancement of the bystander effect by tanshinone IIA (Tan) in HSV-tK/GCV system and the correlation with expression of connexin 43 mRNA.
Methods: The cytotoxic effect in HSV-tK/GCV in cervical carcinoma cell line ME180 (ME) and ME/TK was examined by MTT assays. Cx43 mRNA expression was detected by fluor-quantitative RT-PCR.