Publications by authors named "YuXin Xiang"
Article Synopsis
- Non-small cell lung cancer (NSCLC) is the most prevalent and lethal lung cancer, with its poor outlook linked to complex interactions in the tumor microenvironment.
- The study utilized methylation analysis and high-throughput sequencing to investigate how methylation impacts mRNA characteristics and its regulatory effects on tumor-related genes.
- Findings revealed that high levels of mRNA methylation correlate with changes in tumor microenvironment factors, affecting mRNA stability and translation, and resulting in worse prognosis for NSCLC patients.
The frequency presence of emamectin benzoate in agricultural production highlights the need for studying their toxicity against human intestinal epithelial barrier (IEB). Herein, we combined a Caco-2 cell model with transcriptome analysis to assess the intestinal toxicity of emamectin benzoate and its disease-causing potential. Results showed that the half maximal inhibitory concentration (IC) of emamectin benzoate on Caco-2 cell viability after 24, 48, and 72 h of exposure were 18.
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- Excessive inflammation in the lungs can worsen respiratory diseases due to the release of harmful cytokines and damage to lung tissues, creating a need for effective drugs to combat this issue.
- The study focuses on Protease-activated receptor 2 (PAR2), a target involved in inflammatory responses, and explores how gene editing using CRISPR-Cas9 can modify its role in lung inflammation.
- By using specially designed nanoparticles (TAP) to deliver gene editing tools, researchers found that inhibiting PAR2 helped reduce inflammation in macrophages and provided insights into new drug strategies for treating lung inflammation.
Low-Dose Trypsin Accelerates Wound Healing Protease-Activated Receptor 2.
ACS Pharmacol Transl Sci
January 2024
Article Synopsis
- Wound management poses a major challenge in healthcare, necessitating a deeper understanding of the molecular mechanisms and potential therapeutic methods for effective healing.* -
- This study examined the effects of low-dose trypsin on wound healing, finding that it activates protease-activated receptor 2 (PAR2) to boost fibroblast and macrophage functions, mimicking natural tissue repair processes.* -
- Results showed that low-dose trypsin accelerated healing and collagen deposition while upregulating specific genes involved in cell migration and proliferation, suggesting it could be a beneficial strategy for improving wound healing through PAR2 activation.*
Background: Assessment of the risk of pesticide inhalation in populations around farmland is necessary because inhalation is one of the ways in which pesticides can risk human health. This study aimed to identify the inhalation risk of difenoconazole on humans by using dose-response and exposure assessments.
Results: In the field simulation application, respiratory exposure in populations around farmland ranged from 71 to 430 ng/m .
Bioaccessibility/bioavailability is an important factor in assessing the potential human health risk via oral exposure. However, methods for accurately predicting the bioaccessibility/bioavailability of pesticide residues are still limited, preventing accurate measurements of actual exposure to pesticide residues. In this study, pyrethroid bioavailability in honey were analysed using a mouse bioassay and bioaccessibility via in vitro methods with Tenax extraction.
View Article and Find Full Text PDFInflammatory diseases have become increasingly prevalent throughout the world. Coronavirus disease 2019 (COVID-19), which has recently become pandemic, also exhibits hyperinflammation and cytokine release syndrome. To address inflammation-related diseases, numerous molecular targets have been explored in preclinical studies and clinical trials.
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