Case Report: Dual-chamber pacemaker for hypertrophic cardiomyopathy with bradyarrhythmia and idiopathic pericardial effusion: a report of two cases and literature review.

Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder characterized by asymmetric hypertrophy of the ventricles and the ventricular septum, leading to subsequent left ventricular outflow tract (LVOT) obstruction and diastolic dysfunction. Typically, patients with HCM experience sinus tachycardia and sinus arrest relatively infrequently. In addition, the concurrent occurrence of HCM with non-surgically induced (ablation or myectomy) bradyarrhythmia and idiopathic pericardial effusion in adult patients has not been previously reported.

Pesticide-fertilizer synergistic alginate-based hydrogel for enhanced pesticide retention and nutrient optimization against apple Valsa canker.

The prevalence of apple Valsa canker (AVC) poses a significant threat to the vitality of apple trees, jeopardizing the progress of the apple industry. Current strategies have proven inadequate in managing the disease effectively due to challenges such as extended duration and frequent relapses, especially low-adhesion vertical target. Herein, we introduce a pesticide-fertilizer synergistic alginate-based hydrogel (P&F-Gel) to enhance long-term pesticide retention and offer nutrient supplementation without labor-intensive practices.

Prognostic analysis of sepsis-induced myocardial injury patients using propensity score matching and doubly robust analysis with machine learning-based risk prediction model development.

Background: Sepsis-induced myocardial injury (SIMI) is a severe and common complication of sepsis; However, its definition remains unclear. Prognostic analyses may vary depending on the definition applied. Early prediction of SIMI is crucial for timely intervention, ultimately improving patient outcomes.

Bio-based two-dimensional amphiphile with hierarchical self-assembly for enhancing pesticide utilization and reducing environmental risks.

Background: Biotic and abiotic stresses threaten crop growth and yield. Agrochemicals are an important way to mitigate biotic stress, while frequent low utilization and potential environmental risk affect their sustainable use. In order to improve pesticide utilization, it is common practice to add tank-mix adjuvants by reducing surface tension or forming spherical self-assembly.

Diversity and Evolution of Genes in Species.

genes are crucial components of the effector-triggered immunity (ETI) system, responsible for recognizing pathogens and initiating immune responses. Although genes in many plant species have been extensively studied, the diversity of genes in remains largely unknown. Our analysis revealed significant variations in the copy numbers of genes among these species.

Methazolamide Can Treat Atherosclerosis by Increasing Immunosuppressive Cells and Decreasing Expressions of Genes Related to Proinflammation, Calcification, and Tissue Remodeling.

It has been reported that carbonic anhydrase I (CA1) is a target for the diagnosis and therapy of atherosclerosis (AS) since CA1 can promote AS aortic calcification. We also found that methazolamide (MTZ), a drug for glaucoma treatment and an inhibitor of carbonic anhydrases, can treat AS by inhibiting calcification in aortic tissues. This study focused on the therapeutic mechanism of MTZ and the pathogenic mechanism of AS.

Pan-cancer bioinformatics indicates zinc finger protein 207 is a promising prognostic biomarker and immunotherapeutic target.

In the era of personalized cancer treatment, understanding the complexities of tumor biology and immune modulation is paramount. This comprehensive analysis delves into the multifaceted role of zinc finger protein 207 (ZNF207) in pan-cancer, shedding light on its involvement in tumorigenesis, immune evasion, and therapeutic implications. Through integrated genomic and clinical data analysis, we reveal consistent upregulation of ZNF207 across diverse cancer types, highlighting its potential as a prognostic marker and therapeutic target, particularly for liver cancers.

Harnessing CD8 T cell dynamics in hepatitis B virus-associated liver diseases: Insights, therapies and future directions.

Hepatitis B virus (HBV) infection playsa significant role in the etiology and progression of liver-relatedpathologies, encompassing chronic hepatitis, fibrosis, cirrhosis, and eventual hepatocellularcarcinoma (HCC). Notably, HBV infection stands as the primary etiologicalfactor driving the development of HCC. Given the significant contribution ofHBV infection to liver diseases, a comprehensive understanding of immunedynamics in the liver microenvironment, spanning chronic HBV infection,fibrosis, cirrhosis, and HCC, is essential.

Screening structure and predicting toxicity of pesticide adjuvants using molecular dynamics simulation and machine learning for minimizing environmental impacts.

Surfactants as synergistic agents are necessary to improve the stability and utilization of pesticides, while their use is often accompanied by unexpected release into the environment. However, there are no efficient strategies available for screening low-toxicity surfactants, and traditional toxicity studies rely on extensive experimentation which are not predictive. Herein, a commonly used agricultural adjuvant Triton X (TX) series was selected to study the function of amphipathic structure to their toxicity in zebrafish.

Chromosome-level genome assembly of navel orange cv. Gannanzao (Citrus sinensis Osbeck cv. Gannanzao).

Navel orange cv. Gannanzao is a variant of the navel orange cv. Newhall (Citrus sinensis Osbeck cv.

Erratum: Citrus genomic resources unravel putative genetic determinants of Huanglongbing pathogenicity.

[This corrects the article DOI: 10.1016/j.isci.

Relationship between Increased Plasma Levels of Legumain and Properties of Coronary Atherosclerotic Plaque.

Background: Many clinical studies have confirmed that legumain is closely related to atherosclerosis. Unfortunately, different conclusions have been reached, and analyses and studies on atherosclerotic plaque characteristics in patients with increased plasma levels of legumain are still lacking.

Objectives: This study aimed to investigate the correlation between legumain and coronary atherosclerotic plaque characteristics.

Rosuvastatin Improves Endothelial Dysfunction in Diabetes by Normalizing Endoplasmic Reticulum Stress Calpain-1 Inhibition.

Background: Rosuvastatin contributes to the improvement of vascular complications in diabetes, but the protective mechanisms remain unclear. The aim of the present study was to investigate the effect and mechanism of rosuvastatin on endothelial dysfunction induced by diabetes.

Methods: Calpain-1 knockout (Capn1 EK684-/-) and C57BL/6 mice were intraperitoneally injected with STZ to induce type 1 diabetes.

Facile Preparation of Polysiloxane-Modified Asphalt Binder Exhibiting Enhanced Performance.

The development of polymer-modified asphalt (asphalt = asphalt binder) is significant because the polymer modifier can improve the performance of asphalt mixture and meet the requirements of the modern asphalt pavement. Herein, we present a novel polysiloxane-modified asphalt with enhanced performance, formed by simply mixing hydroxy-terminated polysiloxane (HO-PDMS) into base asphalt at 140 °C. The interaction mechanism of HO-PDMS in base asphalt was characterized by FT-IR, GPC, and DSC.

Using a Dynamic Hydrophilization Strategy to Achieve Nanodispersion, Full Wetting, and Precise Delivery of Hydrophobic Pesticide.

Various strategies have been developed to improve the applicability of hydrophobic pesticides for better effectiveness in agriculture. However, existing formulations of hydrophobic pesticides still suffer from complicated processing, abused organic solvents, indispensable surfactants, or inescapable ecotoxicity, which strictly limit their applications. Herein, a dynamic covalent bond tailored pesticide (fipronil) amphiphile is constructed to address the above issues, which accomplishes the nanodispersion, full wetting, and precise delivery without organic solvents, surfactants, and materials simultaneously.

Enlarged Perivascular Spaces in Relation to Cumulative Blood Pressure Exposure and Cognitive Impairment.

Background: Hypertension and enlarged perivascular spaces (EPVS) are thought to be associated with cognitive impairment. However, the correlations among hypertension, EPVS, and cognitive impairment have not been studied yet. We aimed to investigate the relationships between cumulative blood pressure (cBP) exposure with EPVS and cognitive impairment and whether EPVS may mediate the relationship between cBP and cognitive impairment.

Citrus genomic resources unravel putative genetic determinants of Huanglongbing pathogenicity.

Citrus HLB caused by Liberibacter asiaticus is a pathogen-triggered immune disease. Here, we identified putative genetic determinants of HLB pathogenicity by integrating citrus genomic resources to characterize the pan-genome of accessions that differ in their response to HLB. Genome-wide association mapping and analysis of allele-specific expression between susceptible, tolerant, and resistant accessions further refined candidates underlying the response to HLB.

Folic acid protects against age-associated apoptosis and telomere attrition of neural stem cells in senescence-accelerated mouse prone 8.

Folic acid (FA) could improve cognitive performance and attenuate brain cell injury in the aging brain; FA supplementation is also associated with inhibiting neural stem cell (NSC) apoptosis. However, its role in age-associated telomere attrition remains unclear. We hypothesized that FA supplementation attenuates age-associated apoptosis of NSCs in mice via alleviating telomere attrition in senescence-accelerated mouse prone 8 (SAMP8).

Improved Method to Characterize Leaf Surfaces, Guide Adjuvant Selection, and Improve Glyphosate Efficacy.

Glyphosate, one of the most widely used herbicides, plays an important role in controlling weeds and ensuring crop production. While using glyphosate, adjuvants are commonly added to improve its deposition on weeds and control efficacy. However, changes in weed leaf surface characteristics may reduce glyphosate penetration and contribute to evolved glyphosate resistance.

Promising Delivery Platform for Smart Pest Control with High Water-Retaining Capacity.

Hydrogels have been extensively used in agriculture to improve crop yields for their excellent properties. However, they are currently used either as pesticide delivery platforms or water retention agents alone; the combination of these two functions into one agricultural hydrogel formulation has never been reported, which is crucial to promote sustainable development in agriculture. Herein, using poly(β-cyclodextrin) and adamantane-grafted poly(acrylic acid) (PAA-Ada) as the host and guest, respectively, an easy operating, multi-responsive, and safer hydrogel delivery system for insecticides is fabricated by the host-guest interaction between cyclodextrin and adamantane, which can load uniformly dispersed insecticides (fipronil, imidacloprid, and thiamethoxam) up to 60%.

Complete Mitogenome of Confirms Highly Conserved Gene Arrangement within Family Rhabditidae.

Mitochondrial genomes have widely been used as molecular markers in understanding the patterns and processes of nematode evolution. The species in genus are free-living bacterivores as well as parasites of crickets and mollusks. The complete mitochondrial genome of was determined through high-throughput sequencing as the first sequenced representative of the genus .

The simple strategy to improve pesticide bioavailability and minimize environmental risk by effective and ecofriendly surfactants.

Low pesticide efficiency has caused serious environmental pollution and economic loss, which are closely related to each link in the targeted delivery of pesticides. However, the existing strategies for improving pesticide utilization rate are not comprehensive, and the regulation of foliar absorption and biological activity has been neglected. As surfactants are the most important agricultural synergists, the impact, wetting, adhesion, and leaf retention behaviors of pyraclostrobin (PYR) droplets containing the surfactant Triton X (TX) series on hydrophobic scallion leaf surfaces were studied.

Influence factors associated with health risk behaviors of middle school students in the poverty area of China: An observational study.

We aim to investigate the status and influence factors of health risk behaviors among middle school students and explore the relationship between social support, family care, and the health risk behaviors. The study was conducted in 3 middle schools in the Fan county located in the Puyang city. Independent measures were applied to assess adolescent health risk behaviors, perceive social support, and family care.