Adsorption and Separation by Flexible MOFs.

Flexible metal-organic frameworks (MOFs) offer unique opportunities due to their dynamic structural adaptability. This review explores the impact of flexibility on gas adsorption, highlighting key concepts for gas storage and separation. Specific examples demonstrate the principal effectiveness of flexible frameworks in enhancing gas uptake and working capacity.

SED-YOLO based multi-scale attention for small object detection in remote sensing.

Object detection is crucial for remote sensing image processing, yet the detection of small objects remains highly challenging due to factors such as image noise and cluttered backgrounds. In response to this challenge, this paper proposes an improved network, named SED-YOLO, based on YOLOv5s. Firstly, we leverage Switchable Atrous Convolution (SAC) to replace the standard convolutions in the original C3 modules of the backbone network, thereby enhancing feature extraction capabilities and adaptability.

Noise amplification and ill-convergence of Richardson-Lucy deconvolution.

Richardson-Lucy (RL) deconvolution optimizes the likelihood of the object estimate for an incoherent imaging system. It can offer an increase in contrast, but converges poorly, and shows enhancement of noise as the iteration progresses. We have discovered the underlying reason for this problematic convergence behaviour using a Cramér Rao Lower Bound (CRLB) analysis.

Thunb.: a review on phytochemical composition and pharmacological activities.

Thunb. (. ) is a shrub or tree of the genus , family Lamiaceae, which is widely distributed in China, Korea, India, Japan and Philippines.

Insights into NEK2 inhibitors as antitumor agents: From mechanisms to potential therapeutics.

NEK2, a serine/threonine protein kinase, is integral to mitotic events such as centrosome duplication and separation, microtubule stabilization, spindle assembly checkpoint, and kinetochore attachment. However, NEK2 overexpression leads to centrosome amplification and chromosomal instability, which are significantly associated with various malignancies, including liver, breast, and non-small cell lung cancer. This overexpression could facilitate tumor development and confer resistance to therapy by promoting aberrant cell division and centrosome amplification.

Rapid and in-depth reconstruction of fluorine-doped bimetallic oxide in electrocatalytic oxygen evolution processes.

Most transition metal-based electrocatalysts, when used for the oxygen evolution reaction (OER), undergo significant restructuring under alkaline conditions, forming localized oxides/hydroxides (MOOH), which act as the real active centers, activating adjacent metal sites and creating new active sites that enhance electrocatalytic behavior. Nevertheless, inducing rapid and in-depth self-reconstruction of catalyst surfaces remains a huge challenge. Herein, this work achieves rapid and in-depth self-reconstruction by doping fluorine into the lattice of transition metal oxides (MO).

Nano-Based Strategies Aiming at Tumor Microenvironment for Improved Cancer Therapy.

Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy and chemotherapy, often lack specificity, leading to collateral damage to normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, and elevated ATP levels factors that collectively promote tumor growth and metastasis.

Direct β-C-H ketoalkylation of enaminoesters with cyclopropanols under metal-free conditions.

A TEMPO-mediated β-ketoalkylation of enaminoesters with cyclopropanols under metal-free conditions is herein described. This reaction provides a straightforward and highly efficient route to β-keto alkyl substituted enaminoesters for the first time, which could be rapidly and efficiently converted into synthetically useful 2-alkoxycarbonyl functionalized 1,5-diketones. Moreover, the practicability of this protocol is successfully demonstrated by scale-up experiments and the late-stage functionalization of natural products and pharmaceutically relevant molecules.

Spin effects in regulating the adsorption characteristics of metal ions.

Understanding the adsorption behavior of intermediates at interfaces is crucial for various heterogeneous systems, but less attention has been paid to metal species. This study investigates the manipulation of Co spin states in ZnCoO spinel oxides and establishes their impact on metal ion adsorption. Using electrochemical sensing as a metric, we reveal a quasi-linear relationship between the adsorption affinity of metal ions and the high-spin state fraction of Co sites.

Nomogram and randomized survival forest model for predicting sepsis risk in patients with cerebral infarction in the intensive care unit.

Background: To construct a nomogram and a Randomized Survival Forest (RSF) model for predicting the occurrence of sepsis in patients with cerebral infarction in intensive care units (ICUs).

Methods: A total of 1,963 patients were included from the Medical Information Mart for Intensive Care IV database version 2.0 (MIMIC-IV v2.

Effectiveness of a Multifaceted Intervention (TEMP) for Prevention of Occupational Heat-Related Illness among Outdoor Workers in the Power Grid Industry: A Cluster Randomized Controlled Trial.

Background: Occupational heat-related illness (OHI) is a health threat to workers that can be fatal in severe cases. Effective and feasible measures are urgently needed to prevent OHI.

Objectives: We evaluated the effectiveness of a multifaceted intervention, TEMP, in reducing the OHI risk among outdoor workers in the power grid industry.

Effect of physical exercise on metabolism in patients with atrial fibrillation.

Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, is closely linked to metabolic dysfunctions, including obesity, diabetes, and dyslipidemia. These lead to pathological changes in myocardial metabolism and mitochondrial energy metabolism, thereby aggravating AF's incidence and severity. This review introduces the role of metabolic dysfunctions in exacerbating AF, assesses the therapeutic potential of physical exercise and investigates it as a non-pharmacological intervention to alleviate these metabolic disturbances.

Design of Double Strains in Triboelectric Nanogenerators toward Improving Human Behavior Monitoring.

Triboelectric nanogenerators (TENGs) offer a convenient means to convert mechanical energy from human movement into electricity, exhibiting the application prospects in human behavior monitoring. Nevertheless, the present methods to improve the device monitoring effect are limited to the design of a triboelectric material level (control of electron gain and loss ability). As compared with reported work, we improve the monitoring effect of TENG-based tactile sensors by optimizing the structure of the electrode/triboelectric material interface by means of a multiple strains mechanism.

Room-temperature creation and conversion of individual skyrmion bags in magnetic multilayered disks.

Skyrmion bags, with arbitrary topological charge Q, have recently attracted much interest, since such high-Q topological systems could open a way for topological magnetism research and are promising for spintronic applications with high flexibility for information encoding. Investigation on room-temperature skyrmion bags in magnetic multilayered structures is essential for applications and remains unexplored so far. Here, we demonstrate room-temperature creation and manipulation of individual skyrmion bags in magnetic multilayered disks.

A prodrug nanodevice co-delivering docetaxel and ROR1 siRNA for enhanced triple negative breast cancer therapy.

Triple-negative breast cancer (TNBC) has been a clinical challenge due to its high recurrence and metastasis rates. Chemotherapy remains the primary treatment for TNBC after surgery ablation, but it lacks targeted specificity and causes side effects in normal tissues. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is significantly expressed in TNBC cells, and small interference RNA (siRNA) targeting ROR1 can effectively suppress ROR1 gene expression, thereby inhibiting proliferation and metastasis.

Molecular Dynamics Simulation on the Conformational Change of a pH-Switchable Lipid.

pH-sensitive lipids are important components of lipid nanoparticles, which enable the targeted delivery and controlled release of drugs. Understanding the mechanism of pH-triggered drug release at the molecular level is important for the rational design of ionizable lipids. Based on a recently reported pH-switchable lipid, named SL2, molecular dynamics (MD) simulations were employed to explore the microscopic mechanism behind the membrane destabilization induced by the conformational change of pH-switchable lipids.

Deep learning enhanced quantum holography with undetected photons.

Unlabelled: Holography is an essential technique of generating three-dimensional images. Recently, quantum holography with undetected photons (QHUP) has emerged as a groundbreaking method capable of capturing complex amplitude images. Despite its potential, the practical application of QHUP has been limited by susceptibility to phase disturbances, low interference visibility, and limited spatial resolution.

Serum Lipidomic Signatures Mediate the Association Between Coarse Grain Preference and Central Obesity in Adults With Normal Weight and High Wheat Intake.

Little is known about the association between grain preference and abdominal fat accumulation, and mediating roles of circulating lipidomic signatures. We quantified 1245 circulating lipids in 150 normal-weight central obesity (NWCO) cases and 150 controls using targeted lipidomics. Grain preference was determined by the highest intake frequency of grains (white rice, wheat, or coarse grain).

Substituting time spent in physical activity and sedentary time and its association with cardiovascular disease among northwest Chinese adults.

Objectives: To examine the association between physical activity (PA) and leisure-time sedentary time and cardiovascular disease (CVD).

Methods: This cross-sectional study used baseline data from the Regional Ethnic Cohort Study in Northwest China from June 2018 to May 2019. PA and leisure-time sedentary time were self-reported.

Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion.

Exposure to specific alkali and alkaline earth elements(AEs/AEEs) has been reported that are linked to an increased risk of spontaneous abortion. However, the direct evidence of exposure in the uterus are absent. Therefore, we collected chorionic villi after spontaneous abortion or induced abortion in Peking University Third Hospital.

Synergistic removal of Hg, HCl, and SO from flue gas in municipal solid waste incineration by mechanically modified fly ash.

The emissions of flue gas components (such as Hg, SO, HCl) and the generation of hazardous waste fly ash from municipal waste incineration pose a significant threat to environmental integrity. In this study, a mechanochemical method combined with a modifier is innovatively proposed for the modification of fly ash to remove Hg. In the fixed bed adsorption experiment, the removal efficiency of up to 60 percent can be achieved by ball milling (700rap,30min) alone.