Glycerol monolaurate enhances growth performance, lipid metabolism, and inflammatory response in common carp fed high lipid diets.

A feeding trial was conducted to investigate the effects of glycerol monolaurate (GML) on growth performance, lipid metabolism, inflammation, and related gene expression in common carp fed a high lipid diet. Juvenile common carp were distributed into 18 cages and fed one of six isonitrogenous diets: a normal lipid diet (control diet, CT), a high lipid diet (HL), and high lipid diets supplemented with 0.5, 1, 2, and 4 g kg GML (designated as GML-0.

Evaluation and modeling of diaphragm displacement using ultrasound imaging for wearable respiratory assistive robot.

Introduction: Assessing the influence of respiratory assistive devices on the diaphragm mobility is essential for advancing patient care and improving treatment outcomes. Existing respiratory assistive robots have not yet effectively assessed their impact on diaphragm mobility. In this study, we introduce for the first time a non-invasive, real-time clinically feasible ultrasound method to evaluate the impact of soft wearable robots on diaphragm displacement.

Regulation of lipid metabolism in grass carp primary hepatocytes by exosomes derived from fatty hepatocytes though GRP78.

Exosomes regulate lipid metabolism by carrying miRNAs, nucleic acids, and proteins, thereby influencing the function of receptor cells. Glucose-regulated protein 78 (GRP78) is also involved in the regulation of lipid metabolism. However, it remains unclear whether exosomes derived from fatty hepatocytes (OA-Exo) regulate lipid metabolism through the enrichment of GRP78.

Proteomic analysis of exosomes derived from fatty hepatocytes of grass carp.

Exosomes participate in intercellular communication by carrying proteins, messenger RNA, microRNAs, and non-coding RNA. Fatty liver is a common phenomenon in farmed fish, but there has been little study of fatty hepatocytes-derived exosomes. Here, we successfully isolated exosomes from hepatocytes of grass carp, named Exos (hepatocytes-derived exosomes) and OA-Exos (fatty hepatocytes-derived exosomes), from which 617 differentially expressed proteins were identified using liquid chromatography tandem mass spectrometry.

Extracorporeal Closed-Loop Respiratory Regulation for Patients With Respiratory Difficulty Using a Soft Bionic Robot.

Objective: Respiratory regulation is critical for patients with respiratory dysfunction. Clinically used ventilators can lead to long-term dependence and injury. Extracorporeal assistance approaches such as iron-lung devices provide a noninvasive alternative, however, artificial actuator counterparts have not achieved marvelous biomimetic ventilation as human respiratory muscles.

Database construction and comparative genomics analysis of genes involved in nutritional metabolic diseases in fish.

Nutritional metabolic diseases in fish frequently arise in the setting of intensive aquaculture. The etiology and pathogenesis of these conditions involve energy metabolic disorders influenced by both internal genetic factors and external environmental conditions. The exploration of genes associated with nutritional and metabolic disorder has sparked considerable interest within both the aquaculture scientific community and the industry.

Perceptually Inspired C-Continuity Haptic Shape Display with Trichamber Soft Actuators.

Shape display devices composed of actuation pixels enable dynamic rendering of surface morphological features, which have important roles in virtual reality and metaverse applications. The traditional pin-array solution produces sidestep-like structures between neighboring pins and normally relies on high-density pins to obtain curved surfaces. It remains a challenge to achieve continuous curved surfaces using a small number of actuated units.

Polymeric liposomes targeting dual transporters for highly efficient oral delivery of paclitaxel.

A novel delivery system comprising N-succinic anhydride (N-SAA) and D-fructose co-conjugated chitosan (NSCF)-modified polymeric liposomes (NSCF-PLip) were designed to enhance oral delivery of paclitaxel (PTX) by targeting monocarboxylate transporters (MCT) and glucose transporters (GLUT). The synthesized NSCF was characterised by FT-IR and H NMR spectra. The prepared 30.

A Multi-Layer Stacked Microfluidic Tactile Display With High Spatial Resolution.

Pneumatic tactile displays dynamically customize surface morphological features with reconfigurable arrays of independently addressable actuators. However, their ability to render detailed tactile patterns or fine textures is limited by the low spatial resolution. For pneumatic tactile displays, the high-density integration of pneumatic actuators within a small space (fingertip) poses a significant challenge in terms of pneumatic circuit wiring.

Electrochemical Radical Retro-Allylation of Homoallylic Alcohols with Sulfonyl Hydrazides.

We report herein the first examples of electrochemical radical retro-allylation of homoallylic alcohols via the cleavage of the C(sp)-C(sp) bond. In this reaction, a variety of sulfonyl hydrazides were employed as the environmentally friendly radical sources via an electrochemical dehydrazination with the release of N and H as the byproducts, leading to sulfonyl allylic compounds in moderate to good yields. The reaction features metal- and base-free reaction conditions, broad functional group tolerance, and a broad substrate scope.

Group Haptic Collaboration: Evaluation of Teamwork Behavior during VR Four-Person Rowing Task.

The assessment of multi-person group collaboration has garnered increasing attention in recent years. However, it remains uncertain whether haptic information can be effectively utilized to measure teamwork behavior. This study seeks to evaluate teamwork competency within four-person groups and differentiate the contributions of individual members through a haptic collaborative task.

A skin-integrated device for neck posture monitoring and correction.

Cervical spondylosis is a common disease that is often caused by long-term abnormal cervical curvature due to activities such as reading books and using computers or smartphones. This paper explores building an untethered and skin-integrated device in an e-skin form factor to monitor and haptically correct neck posture. The proposed design features a multilayered structure that integrates all flexible electronic circuits and components into a compact skin space while being untethered and skin conformal.

Voluntary Respiration Control: Signature Analysis by EEG.

The perception of voluntary respiratory consciousness is quite important in some situations, such as respiratory assistance and respiratory rehabilitation training, and the key signatures about voluntary respiration control may lie in the neural signals from brain manifested as electroencephalography (EEG). The present work aims to explore whether there exists correlation between voluntary respiration and scalp EEG. Evoke voluntary respiration of different intensities, while collecting EEG and respiration signal synchronously.

Effective removal of Cr(VI) in water by bulk-size polyaniline/polyvinyl alcohol/amyloid fibril composite beads.

With the rapid expansion of industrial activities, chromium ions are discharged into the environment and cause water and soil pollution of various extents, which seriously endangers the natural ecological environment and human health. In this study, polyaniline/polyvinyl alcohol/amyloid fibril (PANI/PVA/AFL) composite gel beads (PPA) were prepared from polyaniline and amyloid fibrils with HCl as doping acid and PVA as a cross-linking agent. The results showed that PPA was an irregular composite bead with a diameter of 6 mm.

The primary neurotoxic factor, Lansamide I, from Clausena lansium fruits and metabolic dysfunction invoked.

Wampee (Clausena lansium) is a common fruit in South Asia. The pulp is a tasty food, and the seed is a typical traditional herb in China. However, we identified a primary toxic compound, Lansamide I, by NMR and X-ray diffraction of single-crystal.

Novel efficient capture of hexavalent chromium by polyethyleneimine/amyloid fibrils/polyvinyl alcohol aerogel beads: Functional design, applicability, and mechanisms.

The harmful effects of hexavalent chromium (Cr(VI)) on the environment and human health have aroused wide public concern. In this study, bulk spherical aerogel beads (PAP) were synthesized from polyethyleneimine (PEI), protein amyloid fibrils (AFL), and polyvinyl alcohol (PVA) through green technology and its removal of Cr(VI) from wastewater was comprehensively studied. The results showed that although the bulk PAP beads (∼ 5 mm) only had an average pore size of 16.

Determining the Potential Roles of Branched-Chain Amino Acids in the Regulation of Muscle Growth in Common Carp () Based on Transcriptome and MicroRNA Sequencing.

Branched-chain amino acids (BCAAs) can be critically involved in skeletal muscle growth and body energy homeostasis. Skeletal muscle growth is a complex process; some muscle-specific microRNAs (miRNAs) are involved in the regulation of muscle thickening and muscle mass. Additionally, the regulatory network between miRNA and messenger RNA (mRNA) in the modulation of the role of BCAAs on skeletal muscle growth in fish has not been studied.

Identification of multiple regulatory genes involved in TGase production in DSM 40587.

Microbial transglutaminase (TGase) is a protein that is secreted in a mature form and finds wide applications in meat products, tissue scaffold crosslinking, and textile engineering. is the only licensed producer of TGase. However, increasing the production of TGase using metabolic engineering and heterologous expression approaches has encountered challenges in meeting industrial demands.

Global Stability for an Endogenous-Reactivated Tuberculosis Model with Beddington-DeAngelis Incidence, Distributed Delay and Relapse.

A tuberculosis (TB) epidemic model with Beddington-DeAngelis incidence and distributed delay is proposed to characterize the interaction between latent period, endogenous reactivation, treatment of latent TB infection, as well as relapse. The basic reproduction number is defined, and the globally asymptotic stability of disease-free equilibrium is shown when , while if     the globally asymptotic stability of endemic equilibrium is also acquired. Theoretical results are validated through performing numerical simulations, wherein we detect that TB dynamic behavior between models with discrete and distributed delays could be same and opposite, and TB is more persistent in the model with distributed delay.

MateJam: Multi-Material Teeth-Clutching Layer Jamming Actuation for Soft Haptic Glove.

Most existing force feedback gloves use rigid exoskeleton with large structural dimensions, making it challenging to meet the future demand of virtual reality (VR) applications for large-scale end users. There is an urgent need to develop soft and ultrathin gloves similar to daily gloves. Different from the idea of regulating the friction between layers, here we propose a multi-material teeth-clutching layer jamming (MateJam) actuator, which can achieve distinctive bending stiffness in free and constrained space.