Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.

Background & Aims: Sleep disorders (SDs) are common in chronic liver diseases (CLDs). Some SDs arise from impaired internal clock and are, hence, circadian rhythm SDs (CRSDs). Bile acids (BAs), whose levels are increased in many CLDs, reciprocally interact with circadian rhythm.

Nonfragile Impulsive State Estimation for Complex Networks With Markovian Switching Topologies Subject to Limited Bit Rate Constraints.

In this article, we consider the impulsive estimation problem for a specific category of discrete-time complex networks (CNs) characterized by Markovian switching topologies. The measurement outputs of the underlying CNs, transmitted to the observer over wireless networks, are subject to bit rate constraints. To effectively reduce the estimation error and enhance estimation performance, a mode-dependent impulsive observer is proposed that employs the impulse mechanism.

A Homozygous Variant in NAA60 Is Associated with Primary Familial Brain Calcification.

Background: Primary familial brain calcification (PFBC) is a monogenic disorder characterized by bilateral calcifications in the brain. The genetic basis remains unknown in over half of the PFBC patients, indicating the existence of additional novel causative genes. NAA60 was a recently reported novel causative gene for PFBC.

State Estimation for Markovian Jump Neural Networks Under Probabilistic Bit Flips: Allocating Constrained Bit Rates.

In this article, the state estimation problem is studied for Markovian jump neural networks (MJNNs) within a digital network framework. The wireless communication channel with limited bandwidth is characterized by a constrained bit rate, and the occurrence of bit flips during wireless transmission is mathematically modeled. A transmission mechanism, which includes coding-decoding under bit-rate constraints and considers probabilistic bit flips, is introduced, providing a thorough characterization of the digital transmission process.

Bounded synchronization for uncertain master-slave neural networks: An adaptive impulsive control approach.

This paper investigates the bounded synchronization of the discrete-time master-slave neural networks (MSNNs) with uncertainty. To deal with the unknown parameter in the MSNNs, a parameter adaptive law combined with the impulsive mechanism is proposed to improve the estimation efficiency. Meanwhile, the impulsive method also is applied to the controller design for saving the energy.

Frizzled 7 modulates goblet and Paneth cell fate, and maintains homeostasis in mouse intestine.

Intestinal homeostasis depends on interactions between the intestinal epithelium, the immune system and the microbiota. Because of these complicated connections, there are many problems that need to be solved. Current research has indicated that genes targeted by Wnt signaling are responsible for controlling intestinal stem cell fate and for modulating intestinal homeostasis.

Molecular Basis for Luteolin as a Natural TatD DNase Inhibitor in .

TatD960 and TatD825 are DNases that contribute to biofilm formation and virulence in (). Luteolin is a natural flavonoid commonly found in plants that exhibits antimicrobial capacity. Our study aims to investigate the effects of luteolin on TatD DNases as a natural inhibitor.

Luteolin increases susceptibility to macrolides by inhibiting MsrA efflux pump in Trueperella pyogenes.

Trueperella pyogenes (T. pyogenes) is an opportunistic pathogen associated with a variety of diseases in many domestic animals. Therapeutic treatment options for T.

TatD DNases Contribute to Biofilm Formation and Virulence in .

TatD DNases are conserved proteins in a variety of organisms and are considered potential virulence factors in and . However, the function of TatD DNases has not yet been determined in , which causes various infections in animals and leads to economic losses. In this study, we describe the roles of TatD DNases in (TpTatDs).

Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway.

Thoracic aortic aneurysm (TAA) formation is a multifactorial process that results in diverse clinical manifestations and drug responses. Identifying the critical factors and their functions in Marfan syndrome (MFS) pathogenesis is important for exploring personalized medicine for MFS. Methylenetetrahydrofolate reductase , methionine synthase (, and methionine synthase reductase ( polymorphisms have been correlated with TAA severity in MFS patients.

Response surface optimization and antioxidant activity of total proanthocyanidins fraction from Abutilon theophrasti Medic. leaves.

The extraction procedure and antioxidant activity were investigated for total proanthocyanidins extracts from Abutilon theophrasti Medic. leaves collected in August, September and October. The maximum extraction yield was achieved with 90% ethanol, 80°C of heating reflux temperature, 149.

Recent progress in separation prediction of counter-current chromatography.

As a liquid-liquid partition chromatography, counter-current chromatography has advantages in large sample loading capacity without irreversible adsorption, which has been widely applied in separation and purification fields. The main factors, including partition coefficient, two-phase solvent systems, apparatus, and operating parameters greatly affect the separation process of counter-current chromatography. To promote the applications of counter-current chromatography, it is essential to develop theoretical research to master the principles of counter-current chromatographic separations so as to achieve predictions before laborious trials.

The Antibacterial Activity and Mechanism of Action of Luteolin Against .

Purpose: This research aimed to investigate the antibacterial activity and potential mechanism of luteolin against .

Materials And Methods: The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of luteolin against various strains. The potential mechanism of action of luteolin was elucidated through testing and analysing the luteolin-induced alterations of in several aspects, including cell wall, cell membrane, protein expression, nucleic acid content, topoisomerase activity and energy metabolism.

Nonfragile Finite-Time Synchronization for Coupled Neural Networks With Impulsive Approach.

This article addresses the problem of the average stochastic finite-time synchronization (ASFTS) for a set of coupled neural networks (NNs) with energy-bounded noises. Due to the channel capacity constraint, the impulsive approach is introduced so as to cut down the communication times among the leader NNs and the follower NNs. Then, a nonfragile controller is designed to improve the robustness of the controller with randomly occurred uncertainty.

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.

Renal diseases impose considerable health and economic burdens on health systems worldwide, and there is a lack of efficient methods for the prevention and treatment due to their complexity and heterogeneity. Kidneys are organs with a high demand for energy produced by mitochondria, in which Rrm2b has critical functions as reported. The Rrm2b kidney-specific knockout mice we generated exhibited age-dependent exacerbated features, including mitochondrial dysfunction and increased oxidative stress; additionally, resulted in severe disruption of mitochondria-related metabolism.

[Study on musculuskeletal ultrasound features and correlation of knee osteoarthritis].

Objective: To compare the correlation between musculoskeletal ultrasound features, dysfunction and X-ray findings in patients with knee osteoarthritis, and to analyze the pathological mechanism of soft tissue inflammation in knee osteoarthritis.

Methods: Cross-sectional method was performed in this research (Evidence level: III). The patients with knee osteoarthritis were collected according to the screening criteria from September 2016 to January 2017 in Orthopedic clinic in our hospital.

Extraction technology, component analysis, and in vitro antioxidant and antibacterial activities of total flavonoids and fatty acids from Tribulus terrestris L. fruits.

The current study focused on the extraction technology, components analysis, in vitro antioxidant and antibacterial activities of total flavonoids and fatty acids from Tribulus terrestris L. fruits. The extraction process of total flavonoids and fatty acids was optimized by the response surface method, and the compositions were identified from the two extracts by HPLC-DAD-ESI-MS and GC-MS, respectively.

The protective effect of the flavonoid fraction of Abutilon theophrasti Medic. leaves on LPS-induced acute lung injury in mice via the NF-κB and MAPK signalling pathways.

Accompanied by the damages of epithelial and capillary endothelial cell, acute lung injury is diagnosed with the typical pathological symptoms in clinic, including diffusing of pulmonary interstitial, alveolar oedema and hypoxic respiratory insufficiency. Current study focused on the investigation the anti-inflammatory action and mechanisms of total flavonoids extract (TFE) from Abutilon theophrasti Medic. leaves on ALI mice induced by LPSs.

[Correlation of genes expression on MyD 88-dependent signaling pathway in progression of knee osteoarthritis].

Objective: To investigate expression features and correlation of genes expression on MyD88-dependent signaling pathway in synovial membrane (SM) of progression of knee osteoarthritis (OA).

Methods: Sixty Wistar rats were randomly divided into 6 groups, including blank group (N), false surgical group, model groups[2 weeks (2W), 4 weeks (4W), 8 weeks (8W) and 12 weeks (12W)], with 10 rats in each group. The models were established by using Hulth method.