Preparation and Performance Study of MXene-Regulated Ethylene Glycol-Induced WO Film.

This study introduces the development of a W-M electrochromic film, characterized by a "coral"-like TiO@WO heterostructure, synthesized via a hydrothermal process leveraging the inherent instability of MXene. The film showcases exceptional electrochromic performance, with a coloring response time of 2.8 s, a bleaching response time of 4.

Persistent pre-exhausted CD8+ T cells shape the tumor immune microenvironment in anaplastic thyroid cancer.

Anaplastic Thyroid Cancer (ATC) is an aggressive form of cancer with poor prognosis, heavily influenced by its tumor immune microenvironment (TIME). Understanding the cellular and gene expression dynamics within the TIME is crucial for developing targeted therapies. This study analyzes the immune microenvironment of ATC and Papillary Thyroid Cancer (PTC) using single-cell RNA sequencing (scRNA-seq).

Nomogram Based on Immune-Inflammatory Score and Classical Clinicopathological Parameters for Predicting the Recurrence of Endometrial Carcinoma: A Large, Multi-Center Retrospective Study.

Background: Surgery is the best approach to treat endometrial cancer (EC); however, there is currently a deficiency in effective scoring systems for predicting EC recurrence post-surgical resection. This study aims to develop a clinicopathological-inflammatory parameters-based nomogram to accurately predict the postoperative recurrence-free survival (RFS) rate of EC patients.

Methods: A training set containing 1068 patients and an independent validation set consisting of 537 patients were employed in this retrospective study.

Protein arginine methyltransferase 7 modulators in disease therapy: Current progress and emerged opportunity.

Protein arginine methyltransferase 7 (PRMT7) is an essential epigenetic and post-translational regulator in eukaryotic organisms. Dysregulation of PRMT7 is intimately related to multiple types of human diseases, particularly cancer. In addition, PRMT7 exerts multiple effects on cellular processes such as growth, migration, invasion, apoptosis, and drug resistance in various cancers, making it as a promising target for anti-tumor therapeutics.

Pseudo-linkage or real-linkage of rust resistance genes in a wheat-Thinopyrum intermedium translocation line.

We analysed the chromosomal structures of two wheat-Thinopyrum intermedium addition lines Z4 and Z5 and resolved the linkage relationship between the leaf rust and stripe rust resistance genes in Z4. Wheat addition lines Z4 and Z5 carrying rust resistance genes from Thinopyrum intermedium (JJJJStSt, 2n = 6x = 42) together with three wheat lines involved in the production of these addition lines were analysed by rust response, 90K SNP genotyping, and molecular cytogenetic analysis. Seedling leaf rust (LR) responses to five diverse pathotypes indicated that the LR resistance gene(s) was located in translocation chromosome T3DS-3AS.

Structure Revision of Heptacyclic Naphthoquinone Dimer Arnebidin Based on NMR Spectroscopic Analysis and X-ray Crystallography.

Arnebidin, a heptacyclic naphthoquinone dimer with a tricyclo[3.3.0.

Concordance-based Predictive Uncertainty (CPU)-Index: Proof-of-concept with application towards improved specificity of lung cancers on low dose screening CT.

In this paper, we introduce a novel concordance-based predictive uncertainty (CPU)-Index, which integrates insights from subgroup analysis and personalized AI time-to-event models. Through its application in refining lung cancer screening (LCS) predictions generated by an individualized AI time-to-event model trained with fused data of low dose CT (LDCT) radiomics with patient demographics, we demonstrate its effectiveness, resulting in improved risk assessment compared to the Lung CT Screening Reporting & Data System (Lung-RADS). Subgroup-based Lung-RADS faces challenges in representing individual variations and relies on a limited set of predefined characteristics, resulting in variable predictions.

Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension.

Resistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of hypertension prevention and treatment. Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment. Although several single-omics studies have been conducted on RH, its complex pathogenesis has only been partially elucidated.

Assessing severity of pediatric pneumonia using multimodal transformers with multi-task learning.

Objective: While current multimodal approaches in the diagnosis and severity assessment of pneumonia demonstrate remarkable performance, they frequently overlook the issue of modality absence-a common challenge in clinical practice. Thus, we present the (RMT) model, crafted to bridge this gap. The RMT model aims to enhance diagnosis and severity assessment accuracy in situations with incomplete data, thereby ensuring it meets the complex needs of real-world clinical settings.

Naphthalene Hydrodearomatization via Controllable Photocatalytic Hydroboration.

The photocatalytic dearomative 1,4-hydroboration of naphthalenes with an N-heterocyclic carbene borane (NHC-BH) complex was reported herein with controllable regioselectivity and chemoselectivity. This protocol yielded a wide range of naphthalene derivatives bearing various functional groups, notably bioactive compounds. Hydroboration occurred through the cooperation of photoredox and hydrogen atom transfer via boryl radical addition to naphthalene and further selective protonation.

Anthraquinones from the root of Arnebia euchroma (Royle) I. M. Johnst. and their cytotoxic activities.

Twenty-one anthraquinones were discovered from the petroleum ether soluble fraction of the crude ethanol extract of Arnebia euchroma (Royle) I. M. Johnst.

Full-view volumetric photoacoustic imaging using a hemispheric transducer array combined with an acoustic reflector.

Photoacoustic computed tomography (PACT) has evoked extensive interest for applications in preclinical and clinical research. However, the current systems suffer from the limited view provided by detection setups, thus impeding the sufficient acquisition of intricate tissue structures. Here, we propose an approach to enable fast 3D full-view imaging.

Polyethylene hydrogenolysis by dilute RuPt alloy to achieve H-pressure-independent low methane selectivity.

Chemical recycling of plastic waste could reduce its environmental impact and create a more sustainable society. Hydrogenolysis is a viable method for polyolefin valorization but typically requires high hydrogen pressures to minimize methane production. Here, we circumvent this stringent requirement using dilute RuPt alloy to suppress the undesired terminal C-C scission under hydrogen-lean conditions.

2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment.

Background: The prevalence of diabetic cognitive impairment (DCI) is significant, some studies have shown that it is related to mitochondrial respiratory chain homeostasis, but the specific mechanism is not clear. 2-hydroxyisobutyric acid (2-HIBA) is a novel short-chain fatty acid with potential applications in the treatment of metabolic diseases because it can regulate mitochondrial disorders. Our aim was to explore a novel mechanism of action for 2-HIBA in the treatment of DCI in mitochondrial respiratory chain homeostasis.

Colchicine inhibits monosodium urate crystal-mediated inflammation by influencing F-actin formation.

Objectives: To understand the mechanism by which colchicine inhibits the inflammatory properties of monosodium urate (MSU) crystal deposits and tophi.

Methods: We investigated the effects of colchicine on the inflammatory properties of monosodium urate (MSU) crystal deposits in several models: (i) In vitro tophus formation by MSU and neutrophils; (ii) MSU-induced peritonitis model; (iii) Alpha-1-antitrypsin-induced peritoneal MSU flare model; (iv) MSU-induced arthritis model. We measured neutrophil numbers, NET formation, IL-1β production and F-actin generation by MSU crystals.

scMSI: Accurately inferring the sub-clonal Micro-Satellite status by an integrated deconvolution model on length spectrum.

Microsatellite instability (MSI) is an important genomic biomarker for cancer diagnosis and treatment, and sequencing-based approaches are often applied to identify MSI because of its fastness and efficiency. These approaches, however, may fail to identify MSI on one or more sub-clones for certain cancers with a high degree of heterogeneity, leading to erroneous diagnoses and unsuitable treatments. Besides, the computational cost of identifying sub-clonal MSI can be exponentially increased when multiple sub-clones with different length distributions share MSI status.

Downregulation of Notch Signaling-Stimulated Genes in Neurovascular Unit Alterations Induced by Chronic Cerebral Hypoperfusion.

Background: Chronic cerebral hypoperfusion (CCH) is a key contributor to vascular cognitive impairment (VCI) and is typically associated with blood-brain barrier (BBB) damage. This study investigates the pathological mechanisms underlying CCH-induced neurovascular unit (NVU) alterations.

Methods: A mouse model of CCH was established using the bilateral common carotid artery stenosis (BCAS) procedure.

Biomass-Based Sorbent with Superoleophilic from Ulva Prolifera for Oil Spill Cleanup.

In this study, we demonstrate a new all bio-based adsorbent material by treating Enteromorpho prolifera (EP) fibers with tannic acid-ferric chloride complex and then grafting hydrophobic group octadecylamine. All raw materials are easily available, low-cost, and safe. The modified EP fibers have approximately 63.

ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization.

Metastatic dissemination to distant organs demands that cancer cells possess high morphological and metabolic adaptability. However, contributions of the cellular lipidome to metastasis remain elusive. Here, we uncover a correlation between metastasis potential and ferroptosis susceptibility in multiple cancers.

The HLA-A Allele, HLA-A*11:01:01:07, Identified by Third-Generation Sequencing.

HLA-A*11:01:01:07 differs from HLA-A*11:01:01:01 by a single nucleotide exchange in intron 1.

Multispatially Localized DNA Walker Coupling Covalent Organic Framework for Dual-Mode Detection of Nucleocapsid Protein Using the Walking-Recycling-Conversion Strategy.

DNA walkers have emerged as a powerful tool in bioanalysis; however, many existing approaches are still restricted by low reaction kinetics and inaccurate single-mode detection. Herein, a fluorescence (FL) and electrochemical (EC) dual-mode biosensor was proposed based on a multispatially localized DNA walker (m-DNA walker) coupling covalent organic framework (COF) using the walking-recycling-conversion strategy. Specifically, the functionalized COF not only served as a three-dimensional nanocarrier but also acted as an effective quencher of the walking tracks.