Theoretical and experimental study on the consolidation of soil with continuous drainage boundary under electroosmosis-surcharge preloading.

Electroosmosis and surcharge preloading represent two effective soil consolidation methodologies. Their combined application has been proven to be effective in shortening the consolidation period and mitigating the degradation of electroosmotic consolidation performance due to crack generation. In this study, an axisymmetric free-strain consolidation analytical model incorporating a continuous drainage top boundary was established.

High-Brightness Color-Tunable AC-Driven Quantum Dot Light-Emitting Diodes for Integrated Passive High-Electric-Field Contactless Detection.

This work explores the carrier recombination dynamics of AC-driven quantum dot (QD) light-emitting diodes (AC-QLEDs) and proposes their application in the field of electric field contactless detection. Different sequences of green QD (GQD)/red QD (RQD) bilayer thin films as the emission layer of AC-QLEDs were fabricated via film transfer printing to ensure the complete morphology of each layer. AC-QLEDs with the emission layer as the sequence of GQD + RQD (GR-QLEDs) show a significantly enhanced carrier recombination efficiency due to its stable energy level structure, achieving the highest peak brightness ever recorded for vertically emitting brightness of 1648.

The role of lncRNA in the differentiation of adipose-derived stem cells: from functions to mechanism.

Adipose-derived stem cells (ADSCs) have become one of the best seed cells widely studied and concerned in tissue engineering because of their rich sources and excellent multi-directional differentiation ability, which are expected to play a practical application role in tissue defect, osteoporosis, plastic surgery, and other fields. However, the differentiation direction of ADSCs is regulated by complex factors. Long non-coding RNAs (lncRNAs) are RNA molecules longer than 500 nucleotides that do not encode proteins and can act as signaling RNAs in response to intracellular and extracellular stimuli.

Adipose-derived stem cell exosomes attenuates myofibroblast transformation via inhibiting autophagy through TGF-β/Smad2 axis in oral submucosal fibrosis.

Oral submucous fibrosis (OSF) is a precancerous condition that poses substantial health risks. OSF is mainly caused by betel nut chewing behavior, but its pathogenesis is still unclear and there is no effective treatment strategy. The transformation of fibroblasts to myofibroblast is the key pathological change in the development of OSF.

Effect of energy level on reactive oxygen species metabolism during shade-drying of Thompson seedless grapes and its relation to browning.

The browning of Thompson seedless grapes during shade-drying significantly hampers the sustainable and healthy development of the industry. This study investigates the browning phenomenon and reactive oxygen species (ROS) dynamics when Thompson seedless grapes, treated with adenosine triphosphate (ATP), 2,4-dinitrophenol (DNP), and water (QS), are dried in the shade. The effects of these treatments on ROS metabolism were analyzed through physiological, biochemical, and proteomic analyses.

Y01 reduces HFD-induced obesity altering gut microbiota and metabolomic profiles and modulating adipose tissue macrophage M1/M2 polarization.

Obesity-related metabolic syndrome is intimately associated with infiltrated adipose tissue macrophages (ATMs), gut microbiota, and metabolic disorders. holds the potential to mitigate obesity; however, there exist strain-specific functionalities and diverse mechanisms, which deserve extensive exploration. This study aims to explore the potential of Y01, isolated from traditional sour whey, in alleviating HFD-induced metabolic syndrome in mice and elucidating its underlying mechanism.

Suppression of Epidermal Growth Factor Receptor by Erlotinib Attenuates Carvacrol-induced Skin Inflammation.

Epidermal growth factor receptors (EGFRs) regulate the growth and repair process of epithelia, as well as carcinogenesis. Activation of TRPV3 by carvacrol stimulates skin inflammation and epidermal hyperplasia; the latter can be suppressed by EGFR inhibition. However, whether EGFR signalling is responsible for skin inflammation remains elusive.

Warming effects on pelagic carbon metabolism is related to substrate composition and bacterioplankton community history.

Investigating the critical role of carbon cycling feedback to warming is essential for understanding future biosphere development. One of the current challenges is that the warming effect on carbon cycling is inconsistent across various aquatic ecosystems. It was postulated that the composition of dissolved organic matter (DOM) and the microbial community influenced the response of carbon metabolism to warming.

sp. nov. and gen. nov., sp. nov., isolated from freshwater environments in China and re-examining the taxonomic status of genera and .

Three Gram-stain-negative, aerobic, short rod-shaped and motile strains (FXH3W, SHGZ20W and SMYT11W) were isolated from freshwater environments in China. Comparisons based on the 16S rRNA gene sequences indicated that strains FXH3W and SHGZ20W showed the highest 16S rRNA gene sequence similarity of about 99.6% to '' MIC 1.

Scutellarein ameliorates dextran sulfate sodium-induced ulcerative colitis by inhibiting colonic epithelial cell proinflammation and barrier disruption.

Introduction: Scutellarein (Scu) is a natural occurring flavonoid found in multiple traditional Chinese medicines such as indicum (L.) Kurz and , with various pharmacological activities including anti-inflammation, anti-oxidation and myocardial protection. Here, we investigated the therapeutic efficacy of Scu on ulcerative colitis (UC) and the underlying mechanism.

Microbial nitrogen cycling in Microcystis colonies and its contribution to nitrogen removal in eutrophic Lake Taihu, China.

Cyanobacterial blooms induced by excessive loadings of nitrogen (N) and other nutrients are a severe ecological problem in aquatic ecosystems. Previous studies of N removal have primarily focused on sediment-water interface, yet the role of cyanobacterial colonies has recently been attracting more research attention. In this study, N cycling processes were quantified for cyanobacterial colonies (primarily Microcystis colonies) and their contribution to N removal was estimated for a large, shallow eutrophic lake in China, Lake Taihu.

Cortical sites critical to language function act as connectors between language subnetworks.

Historically, eloquent functions have been viewed as localized to focal areas of human cerebral cortex, while more recent studies suggest they are encoded by distributed networks. We examined the network properties of cortical sites defined by stimulation to be critical for speech and language, using electrocorticography from sixteen participants during word-reading. We discovered distinct network signatures for sites where stimulation caused speech arrest and language errors.

Methylparaben changes the community composition, structure, and assembly processes of free-living bacteria, phytoplankton, and zooplankton.

Parabens are common contaminants in river and lake environments. However, few studies have been conducted to determine the effects of parabens on bacteria, phytoplankton, and zooplankton communities in aquatic environments. In this study, the effect of methylparaben (MP) on the diversity and community structure of the aquatic plankton microbiome was investigated by incubating a microcosm with MP at 0.

The application of extracorporeal shock wave therapy on stem cells therapy to treat various diseases.

In the last ten years, stem cell (SC) therapy has been extensively used to treat a range of conditions such as degenerative illnesses, ischemia-related organ dysfunction, diabetes, and neurological disorders. However, the clinical application of these therapies is limited due to the poor survival and differentiation potential of stem cells (SCs). Extracorporeal shock wave therapy (ESWT), as a non-invasive therapy, has shown great application potential in enhancing the proliferation, differentiation, migration, and recruitment of stem cells, offering new possibilities for utilizing ESWT in conjunction with stem cells for the treatment of different systemic conditions.

Drug Product Development and Case Studies for Patient Centric Pediatric Protein-based Therapeutics.

The user of a pediatric drug includes not only the patient, but also their caregiver and healthcare provider, including nurses, doctors, and pharmacists. Therefore, adopting a patient-centric approach that focuses on all users is critical for the development of pediatric drug products. This article outlines the quality target product profile parameters and a patient-centric approach for the development of pediatric protein-based therapies.

Adherent Peanut Image Segmentation Based on Multi-Modal Fusion.

Aiming at the problem of the difficult segmentation of adherent images due to the not fully convex shape of peanut pods, their complex surface texture, and their diverse structures, a multimodal fusion algorithm is proposed to achieve a 2D segmentation of adherent peanut images with the assistance of 3D point clouds. Firstly, the point cloud of a running peanut is captured line by line using a line structured light imaging system, and its three-dimensional shape is obtained through splicing and combining it with a local surface-fitting algorithm to calculate a normal vector and curvature. Seed points are selected based on the principle of minimum curvature, and neighboring points are searched using the KD-Tree algorithm.

[Fetal electrocardiogram signal extraction based on multi-scale residual shrinkage U-Net].

In the extraction of fetal electrocardiogram (ECG) signal, due to the unicity of the scale of the U-Net same-level convolution encoder, the size and shape difference of the ECG characteristic wave between mother and fetus are ignored, and the time information of ECG signals is not used in the threshold learning process of the encoder's residual shrinkage module. In this paper, a method of extracting fetal ECG signal based on multi-scale residual shrinkage U-Net model is proposed. First, the Inception and time domain attention were introduced into the residual shrinkage module to enhance the multi-scale feature extraction ability of the same level convolution encoder and the utilization of the time domain information of fetal ECG signal.

Assessing Photostability of mAb Formulations In Situ Using Light-Coupled NMR Spectroscopy.

Biopharmaceuticals, such as monoclonal antibodies (mAbs), need to maintain their chemical and physical stability in formulations throughout their lifecycle. It is known that exposure of mAbs to light, particularly UV, triggers chemical and physical degradation, which can be exacerbated by trace amounts of photosensitizers in the formulation. Although routine assessments of degradation following defined UV dosages are performed, there is a fundamental lack of understanding regarding the intermediates, transient reactive species, and radicals formed during illumination, as well as their lifetimes and immediate impact post-illumination.

A Review of the Phytochemistry and Biological Activities of .

The main varieties of recorded in the Chinese Pharmacopoeia are the roots of Tausch or Hance. However, the chemical constituents and biological activities of this herb have not been reviewed. In order to clarify the chemical constituents of the main varieties of this herb and improve the quality of Chinese medicinal material resources, this paper systematically reviewed their chemical constituents and related biological activities.