Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis.

Endometriosis and adenomyosis are debilitating gynecological conditions that severely affect the quality of life of women. Traditional diagnostic and treatment methods, including laparoscopic surgery and hormonal therapy, face significant limitations such as incomplete lesion detection, high recurrence rates, and adverse side effects. Emerging bioengineering technologies offer promising solutions for precise diagnosis and therapy of these diseases.

Microwave Sensors and Their Applications in Permittivity Measurement.

This paper reviews microwave sensors and their applications in permittivity measurement. The detection, diagnosis, classification, and monitoring without contact and invasion have been the subject of numerous studies based on permittivity characteristics tracking. This review illustrates many new types of research in recent years.

Altered immune response is associated with sex difference in vulnerability to Alzheimer's disease in human prefrontal cortex.

Alzheimer's disease (AD) is a neurodegenerative disorder with a higher risk incidence in females than in males, and there are also differences in AD pathophysiology between sexes. The role of sex in the pathogenesis of AD may be crucial, yet the cellular and molecular basis remains unclear. Here, we performed a comprehensive analysis using four public transcriptome datasets of AD patients and age-matched control individuals in prefrontal cortex, including bulk transcriptome (295 females and 402 males) and single-nucleus RNA sequencing (snRNA-seq) data (224 females and 219 males).

Uterine first-pass effect: Unlocking the potential of vaginally administered ritodrine-loaded thermosensitive gel for uterine drug delivery.

Preterm birth (PTB) remains a leading cause of infant mortality and morbidity, significantly affecting the long-term health, welfare, and development of newborns. Tocolytics, such as ritodrine, a β-adrenergic receptor agonist, are widely used in developing countries due to their affordability for preventing PTB by inhibiting uterine contractions. However, ritodrine's short half-life necessitates frequent administration, and prolonged high-dose usage often leads to serious maternal side effects, prompting discontinuation.

Structural extracellular matrix-mediated molecular signaling in wound repair and tissue regeneration.

The extracellular matrix (ECM) is a complex, non-cellular network of molecules that offers structural support for cells and tissues. The ECM is composed of various structural components, including collagen, fibronectin, laminin, perlecan, nidogen, tenascin, and fibulin, which are capable of binding to each other and to cell-to-adhesion receptors, endowing the ECM with unique physical and biochemical properties that are essential for its function in maintaining health and managing disease. Over the past three decades, extensive research has shown that the core of the ECM can significantly impact cellular events at the molecular level.

Dermal white adipose tissue: Development and impact on hair follicles, skin defense, and fibrosis.

Dermal white adipose tissue (DWAT) is a distinctive adipose depot located within the lower dermis of the skin. Its significance as an ancillary fat in skin homoeostasis has recently received increased attention. New research has revealed that DWAT responses to skin pathology and physiology changes, impacting skin development, hair cycling, defense mechanisms, and fibrotic conditions.

Treatment of endometriosis with mifepristone mediated by nanostructured lipid carriers.

Mifepristone, a progesterone receptor antagonist, was initially used to terminate early pregnancy. As scientific research advanced, it emerged to be effective in the treatment of various tumors and tumor-like conditions such as endometriosis. Despite the therapeutic potential of mifepristone, its therapeutic effect is still far from ideal because the drug is difficult to dissolve and to accumulate in the target tissue sites.

Highly deformable bi-continuous conducting polymer hydrogels for electrochemical energy storage.

Conducting polymer hydrogels with inherent flexibility, ionic conductivity and environment friendliness are promising materials in the fields of energy storage. However, a trade-off between mechanical and electrochemical properties has limited the development of flexible/stretchable conducting polymer hydrogel electrodes, owing to the intrinsic conflict among mechanical and electrical phases. Here, we report a reliable design to enable conducting polymer with both exceptional mechanical and electrical/electrochemical performance through the construction of bi-continuous conducting polymer crosslinked network.

Biologically templated formation of Cobalt-Phosphide-Graphene hybrids with charge redistribution for efficient hydrogen evolution.

Developing highly efficient and sustainable hydrogen evolution reaction (HER) electrocatalysts is important for the practical application of emerging energy technologies. The spherical structure and phosphorus-rich properties of Chlorella can facilitate the construction of comparable transition metal phosphide electrocatalysts. Here, a microorganism template strategy is proposed to construct a cobalt-phosphide-graphene hybrid.

Intensification of rice flour gel structure by fermenting corresponding rice with .

In starch gel foods processing, lactic acid fermentation is an effective strategy to improve the quality of the gel. This study revealed the effects of fermentation for rice on the textural and rheological properties of the corresponding gels. The hardness, adhesiveness and chewiness of the gel showed ascending trends with the forwarding of fermentation.

Expression characteristics and potential function of non-coding RNA in mouse cortical cells.

Non-coding RNAs (ncRNAs) play essential regulatory functions in various physiological and pathological processes in the brain. To systematically characterize the ncRNA profile in cortical cells, we downloaded single-cell SMART-Seq v4 data of mouse cerebral cortex. Our results revealed that the ncRNAs alone are sufficient to define the identity of most cortical cell types.

Young human plasma-derived extracellular vesicles rescue and reactivate IL-1β and TNF-α treated chondrocytes.

Osteoarthritis (OA) is a degenerative disease that affects millions of individuals worldwide. Despite its prevalence, the exact causes and mechanisms behind OA are still not fully understood, resulting in a lack of effective treatments to slow down or halt disease progression. Recent research has discovered that extracellular vesicles (EVs) present in the circulation of young mice have a remarkable ability to activate musculoskeletal stem cells in elderly mice.

Generic heterostructure interfaces bound to CoS for efficient overall water splitting supported by photothermal.

The increase of reaction temperature of electrocatalysts and the construction of heterogeneous structures is regarded as an efficient method to improve the electrocatalytic water splitting activity. Here, we report an approach to enhance the local heat and active sites of the catalyst by building a heterostructure with CoS to significantly improve its electrocatalytic performance. The as-fabricated CoS@Ce-NiCo LDH/NF electrode possesses a notable photothermal ability, as it effectively converts near-infrared (NIR) light into the local heat, owing to its significant optical absorption.

Detection of extreme hydrological droughts in the poyang lake basin during 2021-2022 using GNSS-derived daily terrestrial water storage anomalies.

Poyang Lake is the largest freshwater lake in China, serving as a natural reservoir and playing a paramount role in climate regulation, ecological environment, and water resource management. However, in recent years, Poyang Lake has approached desiccation multiple times, with severe droughts becoming increasingly common. Consequently, precise quantification and analysis of the terrestrial water storage anomalies (TWSA) and drought characteristics of the Poyang Lake basin (PLB) are of profound scientific and practical significance.

Organic Thin Films Enable Retaining the Oxidation State of Copper Catalysts during CO Electroreduction.

A key challenge in electrocatalysis remains controlling a catalyst's structural, chemical, and electrical properties under reaction conditions. While organic coatings showed promise for enhancing the selectivity and stability of catalysts for CO electroreduction (CORR), their impact on the chemical state of underlying metal electrodes has remained unclear. In this study, we show that organic thin films on polycrystalline copper (Cu) enable retaining Cu species at reducing potentials down to -1.

Biomass substrate-derived graphene-like N-doped porous carbon nanosheet-supported PtCo nanocatalyst for efficient and selective hydrogenation of unsaturated furanic aldehydes.

Unsaturated furanic aldehydes are derived from lignocellulosic biomass resources and subsequently used to produce valuable chemicals. However, the highly efficient, selective hydrogenation of the biomass-derived unsaturated furan CO bond remains challenging. Here we report that graphene-like nitrogen doped porous carbon (GNPC) nanosheets are synthesized from carbon-rich, sustainable, and renewable biomass precursors (glucose, fructose and 5-hydroxymethylfurfural, HMF) with high surface areas, large pore volumes and narrow mesopores.

Nano wear particles and the periprosthetic microenvironment in aseptic loosening induced osteolysis following joint arthroplasty.

Joint arthroplasty is an option for end-stage septic arthritis due to joint infection after effective control of infection. However, complications such as osteolysis and aseptic loosening can arise afterwards due to wear and tear caused by high joint activity after surgery, necessitating joint revision. Some studies on tissue pathology after prosthesis implantation have identified various cell populations involved in the process.

MRI Manifestations of Primary Intraspinal Synovial Sarcoma: A Case Report.

Unlabelled: Synovial sarcomas represent a highly malignant form of mesenchymal tumors. The incidence of synovial sarcomas in the spinal canal is exceptionally rare and has been scarcely reported.

Teaching Point: Comprehending the magnetic resonance imaging manifestations of intraspinal synovial sarcoma is important to prevent misdiagnosis.

Sequence variety in the CC' loop of Siglec-8/9/3 determines the recognitions to sulfated oligosaccharides.

Siglecs are important lectins found in different types of immune cells and function as regulatory molecules by recognizing self-associated glycans and converting extracellular interactions into signals for inhibiting immune cell functions. Although many Siglecs have been found to show broad specificities and recognize different types of sulfated oligosaccharides, Siglec-8 and Siglec-9 displayed a high degree of specificity for sialyl -acetyllactosamine (sLacNAc) with sulfations at O6-positions of the galactose (6'-sulfation) and -acetylglucosamine (6-sulfation), respectively. Siglec-3 was recently discovered to bind sLacNAc both sulfations.

Intense ultraviolet-visible-infrared full-spectrum laser.

A high-brightness ultrabroadband supercontinuum white laser is desirable for various fields of modern science. Here, we present an intense ultraviolet-visible-infrared full-spectrum femtosecond laser source (with 300-5000 nm 25 dB bandwidth) with 0.54 mJ per pulse.