AI-Assisted Compressed Sensing Enables Faster Brain MRI for the Elderly: Image Quality and Diagnostic Equivalence with Conventional Imaging.

Purpose: Conventional brain MRI protocols are time-consuming, which can lead to patient discomfort and inefficiency in clinical settings. This study aims to assess the feasibility of using artificial intelligence-assisted compressed sensing (ACS) to reduce brain MRI scan time while maintaining image quality and diagnostic accuracy compared to a conventional imaging protocol.

Patients And Methods: Seventy patients from the department of neurology underwent brain MRI scans using both conventional and ACS protocols, including axial and sagittal T2-weighted fast spin-echo sequences and T2-fluid attenuated inversion recovery (FLAIR) sequence.

A Solvatochromic and Photosensitized Lipid Droplet Probe Detects Local Polarity Heterogeneity and Labels Interacting Proteins in Human Liver Disease Tissue.

The intricate morphology, physicochemical properties, and interacting proteins of lipid droplets (LDs) are associated with cell metabolism and related diseases. To uncover these layers of information, a solvatochromic and photosensitized LDs-targeted probe based on the furan-based D-D-π-A scaffold is developed to offer the following integrated functions. First, the turn-on fluorescence of the probe upon selectively binding to LDs allows for direct visualization of their location and morphology.

Characterization changes of volatile organic compounds in Aconitum sinomontanum Nakai (Gao Wu Tou) with different proportions of yellow wine steamed by GC-IMS, E-nose.

Gas chromatography-ion mobility spectrometry (GC-IMS) combined with multiple analytical methods and E-nose were used to study the differences in volatile organic compounds (VOCs) in 0 %, 10 %, 15 %, 20 %, 25 % yellow wine steamed A. sinomontanum and its raw products. The results indicated that the VOCs in different proportions of yellow wine steamed A.

A comprehensive classification and analysis of oily sensitive facial skin: a cross-sectional study of young Chinese women.

Oily sensitive skin is complex and requires accurate identification and personalized care. However, the current classification method relies on subjective assessment. This study aimed to classify skin type and subtype using objective biophysical parameters to investigate differences in skin characteristics across anatomical and morphological regions.

Recombinant collagen microneedles for transdermal delivery of antibacterial copper-DNA nanoparticles to treat skin and soft tissue infections.

Skin and soft tissue infections (SSTI) include bacterial infections of the skin, muscles, and connective tissue such as ligaments and tendons. SSTI in patients with immunocompromising diseases may lead to chronic, hard-to-heal infected wounds, resulting in disability, amputation, or even death. To treat SSTI and rebuild the defensive barrier of the skin, here we utilize recombinant type XVII collagen protein (rCol XVII) to construct biodegradable, regenerative collagen microneedles (rCol-MNs) for transdermal delivery of antibacterial agents.

Deep learning-based discovery of compounds for blood pressure lowering effects.

The hypotensive side effects caused by drugs during their use have been a vexing issue. Recent studies have found that deep learning can effectively predict the biological activity of compounds by mining patterns and rules in the data, providing a potential solution for identifying drug side effects. In this study, we established a deep learning-based predictive model, utilizing a data set comprised of compounds known to either elevate or lower blood pressure.

An Integrated Whole-Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction.

The harsh microenvironment of the urethral injury often carries high risks of early undesirable healing as well as late scar tissue formation. Indeed, the infection and inflammatory response in the early stages as well as blood vessel formation and tissue regeneration in the later stages fundamentally impact the outcomes of urethral wound healing. Innovatively, an integrated whole-process repair hydrogel (APF/C/L@dECM) is designed.

Patterning technologies of quantum dots for color-conversion micro-LED display applications.

Quantum dot (QD) materials and their patterning technologies play a pivotal role in the full colorization of next-generation Micro-LED display technology. This article reviews the latest development in QD materials, including II-VI group, III-V group, and perovskite QDs, along with the state of the art in optimizing QD performance through techniques such as ligand engineering, surface coating, and core-shell structure construction. Additionally, it comprehensively covers the progress in QD patterning methods, such as inkjet printing, photolithography, electrophoretic deposition, transfer printing, microfluidics, and micropore filling method, and emphasizes their crucial role in achieving high precision, density, and uniformity in QD deposition.

Single/joint effects of pyrene and heavy metals in contaminated soils on the growth and physiological response of maize ( L.).

The widespread presence of polycyclic aromatic hydrocarbons (PAHs) and toxic heavy metals in soils is having harmful effects on food crops and the environment. However, the defense mechanisms and capacity of plants to counteract these substances have not been comprehensively explored, necessitating a systematic categorization of their inhibitory effects. Accordingly, an experimental investigation was conducted to examine the growth and physiological response of maize ( L.

Sugar Transport and Signaling in Shoot Branching.

The source-sink relationship is critical for proper plant growth and development, particularly for vegetative axillary buds, whose activity shapes the branching pattern and ultimately the plant architecture. Once formed from axillary meristems, axillary buds remain dormant or become active to grow into new branches. This transition is notably driven by the regulation of the bud sink strength, which is reflected in the ability to unload, metabolize and store photoassimilates.

Advances of New Extracellular Vesicle Isolation and Detection Technologies in Cancer Diagnosis.

Cancer is a global health issue threatening people's lives. Currently, cancer detection methods still have a lot of room for improvement in both efficiency and accuracy. The development and application of new technologies are urgently required for early cancer diagnosis and prognosis.

Meiotic crossovers revealed by differential visualization of homologous chromosomes using enhanced haplotype oligo-painting in cucumber.

The interaction dynamics of homologous chromosomes during meiosis, such as recognition, pairing, synapsis, recombination, and segregation are vital for species fertility and genetic diversity within populations. Meiotic crossover (CO), a prominent feature of meiosis, ensures the faithful segregation of homologous chromosomes and enriches genetic diversity within a population. Nevertheless, visually distinguishing homologous chromosomes and COs remains an intractable challenge in cytological studies, particularly in non-model or plants with small genomes, limiting insights into meiotic dynamics.

Endosulfan promotes cell growth, migration and invasion via CCL5/CCR5 axis in MCF-7 cells.

Endosulfan, recognized as an endocrine disruptor, has emerged as an important risk factor for human breast cancer. The chemokine ligand 5 (CCL5) and its receptor CCR5 constitute a biological axis, that is implicated in tumorigenesis and cancer progression. However, the role of the CCL5/CCR5 axis in breast cancer when exposure to endosulfan remains unclear.

Pathogenesis and treatment of colitis-associated colorectal cancer: Insights from Traditional Chinese Medicine.

Ethnopharmacological Relevance: Inflammatory Bowel Disease (IBD) is an inflammatory intestinal disease, and with prolonged illness duration, the annual risk of IBD progressing to colitis-associated colorectal cancer (CAC) gradually increases. In recent years, there has been a noticeable trend towards the application of traditional Chinese medicine (TCM) in the treatment of CAC.

Aim Of This Review: This comprehensive review summarizes the pathogenesis of CAC and details the therapeutic benefits of TCM in treating CAC, including various TCM prescriptions and ingredients, establishing the theoretical foundation for the application of TCM in CAC treatment.

Development of a hamster model of spontaneous hypertriglyceridemia in diabetes.

Hypertriglyceridemia (HTG) often accompanies diabetes and is considered a risk factor for diabetic vascular complications. However, inducing diabetic HTG typically requires high-fat diets in certain animal models. Leveraging our newly developed LDL receptor knockout hamster model, which exhibits features akin to human lipid metabolism, we sought to determine whether these animals would develop HTG without dietary manipulations in diabetes.

A novel computer-assisted system for long bone fracture reduction with a hexapod external fixator.

Objective: Accurate alignment of long bone fractures under minimally invasive procedures is a prerequisite for excellent treatment outcomes. However, the existing technologies suffer from the drawbacks of complex operations and excessive dependence on the surgeon's expertise. To solve these problems, we have developed a novel computer-assisted system to achieve rapid and effective reduction of fractures.

Scaffold-based tissue engineering strategies for urethral repair and reconstruction.

Urethral strictures are common in urology; however, the reconstruction of long urethral strictures remains challenging. There are still unavoidable limitations in the clinical application of grafts for urethral injuries, which has facilitated the advancement of urethral tissue engineering. Tissue-engineered urethral scaffolds that combine cells or bioactive factors with a biomaterial to mimic the native microenvironment of the urethra, offer a promising approach to urethral reconstruction.

Opto-twistronic Hall effect in a three-dimensional spiral lattice.

Studies of moiré systems have explained the effect of superlattice modulations on their properties, demonstrating new correlated phases. However, most experimental studies have focused on a few layers in two-dimensional systems. Extending twistronics to three dimensions, in which the twist extends into the third dimension, remains underexplored because of the challenges associated with the manual stacking of layers.