The impact of small food workshops management regulations on aflatoxin B in home-made peanut oil and the liver function of high-consumption area residents: an interrupted time series study in Guangzhou, China.

Background: Aflatoxin B (AFB), a potent carcinogen produced by species, is a prevalent contaminant in oil crops, with prolonged exposure associated with liver damage. Home-made peanut oil (HMPO) produced by small workshops in Guangzhou is heavily contaminated with AFB. Despite the enactment of the Small Food Workshops Management Regulations (SFWMR), no quantitative assessment has been conducted regarding its impact on food contamination and public health.

Single-cell transcriptomics reveal the prognostic roles of epithelial and T cells and DNA methylation-based prognostic models in pancreatic cancer.

Background: Pancreatic adenocarcinoma (PDAC) exhibits a complex microenvironment with diverse cell populations influencing patient prognosis. Single-cell RNA sequencing (scRNA-seq) was used to identify prognosis-related cell types, and DNA methylation (DNAm)-based models were developed to predict outcomes based on their cellular characteristics.

Methods: We integrated scRNA-seq, bulk data, and clinical information to identify key cell populations associated with prognosis.

Magic methylation with methyl-containing peroxides.

Methyl groups rank among the most abundant carbon fragments found in natural products and small-molecule pharmaceuticals. The late-stage and environmentally friendly installation of these groups onto biologically active molecules has attracted widespread attention in both industry and academia. In 2008, we published the first use of a methyl radical derived from a peroxide toward a directed transition-metal catalysed C-H methylation.

Relapse risk factors analysis within 1 year after the first onset of neuromyelitis optica spectrum disorders: A two-center retrospective study.

Background: Neuromyelitis optica spectrum disorders (NMOSD) is a highly relapsing and disabling disease that causes severe neurological dysfunction in young patients and often has a poor prognosis. Our study aimed to investigate risk factors affecting NMOSD relapse and to establish a relapse prediction model within 1 year after the first onset, providing a reference for individualized diagnosis and treatment of NMOSD patients.

Methods: We retrospectively analyzed clinical data of 102 NMOSD patients admitted to the Second Affiliated Hospital of Soochow University and the Second People's Hospital of Wuxi from January 2020 to August 2023 at their initial presentation.

Shielding the Hägg carbide by a graphene layer for ultrahigh carbon efficiency during syngas conversion.

Fischer-Tropsch synthesis represents a key endeavor aimed at converting nonpetroleum carbon resources into clean fuels and valuable chemicals. However, the current state-of-the-art industrial FTS employing Fe-based catalysts is still challenged by the low carbon efficiency (<50%), mainly attributed to the prominent formation of CO and CH resulting from the nonregulated side water gas shift reaction. Herein, we describe a shielding strategy involving the encapsulation of the active Hägg carbide (χ-FeC) by a graphene layer, exhibiting excellent resilience under reaction conditions and exposure to air, thereby eliminating the need for reduction or activation before the Fischer-Tropsch synthesis reaction.

Co Cluster-Modified Ni Nanoparticles with Superior Light-Driven Thermocatalytic CO Reduction by CH.

Excessive fossil burning causes energy shortages and contributes to the environmental crisis. Light-driven thermocatalytic CO reduction by methane (CRM) provides an effective strategy to conquer these two global challenges. Ni-based catalysts have been developed as candidates for CRM that are comparable to the noble metal catalysts.

Development of Simple Sequence Repeat of (Coleoptera: Cerambycidae) Based on Restriction Site-Associated DNA Sequencing.

, a pest posing a serious threat to coniferous species, such as , has had devastating effects on pine forests due to its association with . The creation of unique simple sequence repeat (SSR) primers for is crucial, as there has been little study of the species' phylogeography. The aim of this study was to identify and create polymorphic SSR primers by sequencing samples of obtained from three different sampling points using the restriction site-associated DNA sequencing (Red-seq) approach.

Frontiers in artificial intelligence-directed light-sheet microscopy for uncovering biological phenomena and multi-organ imaging.

Light-sheet fluorescence microscopy (LSFM) introduces fast scanning of biological phenomena with deep photon penetration and minimal phototoxicity. This advancement represents a significant shift in 3-D imaging of large-scale biological tissues and 4-D (space + time) imaging of small live animals. The large data associated with LSFM requires efficient imaging acquisition and analysis with the use of artificial intelligence (AI)/machine learning (ML) algorithms.

Solvent-Controlled Strategy for Color-Tunable Fluorescence Carbon Dots and Their Application in Light-Emitting Diodes.

Carbon dots (CDs) offer tremendous advantages in the fields such as bioimaging, sensing, biomedicine, catalysis, information encryption, and optoelectronics. However, the inherent challenge is synthesizing CDs with a full-spectrum emission, as most CDs typically produce only blue or green emissions, which severely hinder further investigation into their fluorescence mechanism and restrict their broader applications in light-emitting diodes (LEDs). In this work, we reported a solvent-controlled strategy for the preparation of multicolor CDs with blue, yellow, and red emissions, using -phenylenediamine (PD) and ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF) as precursors.

The efficacy of orally administered L-carnitine in alleviating ovarian dysfunctions has laid the foundation for targeted use: a study employing self-control and propensity score matching.

Objective: This study aimed to evaluate the effectiveness of oral L-carnitine administration in patients after treatment failure to lay the groundwork for targeted use.

Methods And Materials: A total of 515 Fertilization (IVF) patients undergoing subsequent cycles were included after applying exclusion criteria. They were divided into a control group of 362 patients and a study group of 153 patients who received oral L-carnitine until oocyte retrieval.

The Tree Shrew Model of Parkinson Disease: A Cost-Effective Alternative to Nonhuman Primate Models.

The surge in demand for experimental monkeys has led to a rapid increase in their costs. Consequently, there is a growing need for a cost-effective model of Parkinson disease (PD) that exhibits all core clinical and pathologic phenotypes. Evolutionarily, tree shrews (Tupaia belangeri) are closer to primates in comparison with rodents and could be an ideal species for modeling PD.

The superior value of radiomics to sonographic assessment for ultrasound-based evaluation of extrathyroidal extension in papillary thyroid carcinoma: a retrospective study.

Background: Extrathyroidal extension was related with worse survival for patients with papillary thyroid carcinoma. For its preoperative evaluation, we measured and compared the predicting value of sonographic method and ultrasonic radiomics method in nodules of papillary thyroid carcinoma.

Patients And Methods: Data from 337 nodules were included and divided into training group and validation group.

Decoding the microbiota metabolome in hepatobiliary and pancreatic cancers: Pathways to precision diagnostics and targeted therapeutics.

We delve into the critical role of the gut microbiota and its metabolites in the pathogenesis and progression of hepatobiliary and pancreatic (HBP) cancers, illuminating an urgent need for breakthroughs in diagnostic and therapeutic strategies. Given the high mortality rates associated with HBP cancers, which are attributed to aggressive recurrence, metastasis, and poor responses to chemotherapy, exploring microbiome research presents a promising frontier. This research highlights how microbial metabolites, including secondary bile acids, short-chain fatty acids, and lipopolysaccharides, crucially influence cancer cell behaviors such as proliferation, apoptosis, and immune evasion, significantly contributing to the oncogenesis and progression of HBP cancers.

Including the rare cubane cluster cobalt coordination polymer as the fluorescent sensing material for selectively and sensitively detecting the nitrofurantoin antibiotic.

More and more attention has been paid to food safety. Due to the overuse and misuse of antibiotics, the problem of antibiotic residues in animal food is one of the important challenges to ensure food safety. The development of a feasible strategy to detect antibiotic residues in animal food has become desirable.

PRRSV hijacks DDX3X protein and induces ferroptosis to facilitate viral replication.

Porcine reproductive and respiratory syndrome virus (PRRSV) is a severe disease with substantial economic consequences for the swine industry. The DEAD-box helicase 3 (DDX3X) is an RNA helicase that plays a crucial role in regulating RNA metabolism, immunological response, and even RNA virus infection. However, it is unclear whether it contributes to PRRSV infection.

Self-assembled dipeptide confined in covalent organic polymers for fluorescence sensing of tryptamine in fermented meat products.

Diphenylalanine(FF)-Zn self-assembly (FS) confined in covalent organic polymers (FS@COPs) with efficient fluorescence was synthesized for fluorescence sensing of biogenic amines, which was one of the most important indicators for monitoring food freshness. FS@COPs combined excellent biodegradability of self-assembled dipeptide with chemical stability, porosity and targeted site recognition of COPs. With an optimal excitation wavelength of 360 nm and an optimal emission wavelength of 450 nm, FS@COPs could be used as fluorescence probes to rapidly visualize and highly sensitive determination of tryptamine (Try) within 15 min, and the linear range was from 40 to 900 μg L with a detection limit of 63.

Strain Effects in the Work Function and Charge Transfer of the Au(111) Surface.

Work function (WF) is one of the most fundamental physical parameters of metal surfaces, which can not only reflect the electronic structure of metal surfaces but is also very sensitive to the surface microstructure. In this paper, we use first-principles calculations to systematically study the strain effects on the vacuum level, Fermi level, and WF of the Au(111) surface. We find that the vacuum level and Fermi level of the Au(111) surface increase under compressive strain and decrease under tensile strain, and the effects of biaxial strain on the vacuum level and Fermi level can be equivalent to the superposition of two perpendicular uniaxial strains.

[Retracted] MicroRNA‑126 exerts antitumor functions in ovarian cancer by targeting EGFL7 and affecting epithelial‑to‑mesenchymal transition and ERK/MAPK signaling pathway.

[This retracts the article DOI: 10.3892/ol.2020.

Modeling Human Macular Cone Photoreceptor Spatial Distribution.

Purpose: The purpose of this study was to investigate the spatial distribution of human cone photoreceptors and examine cone density differences between the retinal meridians and quadrants.

Method: Using adaptive optics scanning laser ophthalmoscopy, the maculae were imaged in 17 eyes of 11 subjects with normal chorioretinal health aged 54 to 72 years. We measured cone density at 325 points within the central 10 degrees radius of the retina.

Fischer-Tropsch Synthesis of C-C Isoparaffins via CoMnO Nanocomposites with Suppressed CO.

The synthesis of a specific product via the Fischer-Tropsch synthesis remains challenging due to the uncontrollable coupling of CH on active sites. Isoparaffins, essential high-quality petroleum additives for improving octane numbers, are primarily derived from petroleum or natural gas. With petroleum reserves dwindling and the associated low selectivity, the direct conversion of syngas to isoparaffins has emerged as a promising alternative.

Alterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients.

Background: Patients with pancreatic ductal adenocarcinoma (PDAC) display an altered oral, gastrointestinal, and intra-pancreatic microbiome compared to healthy individuals. However, knowledge regarding the bile microbiome and its potential impact on progression-free survival in PDACs remains limited.

Methods: Patients with PDAC (n = 45), including 20 matched pairs before and after surgery, and benign controls (n = 16) were included prospectively.

Fabrication of fluorescence probe based on molecularly imprinted polymers on red emissive biomass-derived carbon dots coupled with smartphone readout for tyramine determination in fermented meat products.

A fluorescence probe based on molecularly imprinted polymers on red emissive biomass-derived carbon dots (r-BCDs@MIPs) was developed to detect tyramine in fermented meat products. The red emissive biomass-derived carbon dots (r-BCDs) were synthesized by the one-step solvothermal method using discarded passion fruit shells as raw materials. The fluorescence emission peak of r-BCDs was at 670 nm, and the relative quantum yield (QY) was about 2.