The Change of Skeletal Muscle Caused by Inflammation in Obesity as the Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies.

Obesity leads to a chronic inflammatory state throughout the body, with increased infiltration of immune cells and inflammatory factors in skeletal muscle tissue, and, at the same time, the level of intracellular mitochondrial oxidative stress rises. Meanwhile, obesity is closely related to the development of skeletal muscle fibrosis and can affect the metabolic function of skeletal muscle, triggering metabolic disorders such as insulin resistance (IR) and type 2 diabetes (T2D). However, whether there is a mutual regulatory effect between the two pathological states of inflammation and fibrosis in obese skeletal muscle and the specific molecular mechanisms have not been fully clarified.

Risk of acute kidney injury following repeated contrast exposure in trauma patients.

Purpose: This study investigates the risk of contrast-associated acute kidney injury (CA-AKI) in trauma patients, focusing on the impact of cumulative contrast medium doses.

Methods: A retrospective review was conducted at a level 1 trauma center (2019-2021). The study included patients who underwent intravascular contrast-enhanced examinations for torso trauma within 7 days post-injury.

Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine.

Metabolic syndrome (MetS) is a difficult-to-manage disease that poses a significant risk to human health. Here, we show that the supplementation of Lactobacillus reuteri ZJ617 ameliorates symptoms of MetS in mice induced by the high-fat diet. L.

Research on the Anxiety and Depression of Patients with Mechanical Ocular Injuries: A Cross-Sectional Study.

Purpose: The present study aimed to investigate the prevalence of anxiety and depression in patients with mechanical ocular injuries, and the effects of worry and resilience on anxiety and depression.

Patients And Methods: Patients with one eye of mechanical ocular injuries and healthy residents were recruited from June 8, 2022, to March 1, 2023. All subjects participated in psychologically relevant questionnaires including the Self-rating Anxiety Scale(SAS), the Self-rating Depression Scale(SDS), the Connor- Davidson Resilience Scale (CD-RISC), and the Penn State Worry Questionnaire(PSWQ).

Causal Relationship Between Intestinal Microbiota, Inflammatory Cytokines, Peripheral Immune Cells, Plasma Metabolome and Parkinson's Disease: A Mediation Mendelian Randomization Study.

Parkinson's disease (PD) is a neurodegenerative disease involving multiple factors. We explored the connection between intestinal microbiome levels and PD by examining inflammatory cytokines, peripheral immune cell counts and plasma metabolomics as potential factors. By obtaining the Genome-Wide Association Study (GWAS) data needed for this study from GWAS Catalog, including summary data for 473 intestinal microbiota traits (N = 5959), 91 inflammatory cytokine traits (N = 14,824), 118 peripheral immune cell count traits (N = 3757), 1400 plasma metabolite traits (N = 8299) and PD traits (N = 482,730).

The ethanolic extract of Rhaphidophora peepla prevents inflammation by inhibiting the activation of Syk/AKT/NF-κB and TAK1/MAPK/AP-1.

Background: Inflammation is the body's innate reaction to foreign pathogens and serves as a self-regulating mechanism. However, the immune system can mistakenly target the body's own tissues, triggering unnecessary inflammation. For millennia, medicinal plants have been employed for the treatment of diseases.

Chinese burden of depressive disorders from 1990 to 2021 and prediction for 2030: analysis of data from the global burden of disease study 2021.

Background: This study aims to examine the temporal changes in the incidence, prevalence, and disability-adjusted life years (DALYs) of depressive disorders as well as its association with age, period, and birth cohort among Chinese from 1990 to 2021, and forecast the future trends of incidence rates and numbers from 2022 to 2030.

Methods: Data for analysis were obtained from the Global Burden of Disease (GBD) 2021. Joinpoint analysis was used to calculate the annual percentage change (APC) and average annual percent change (AAPC) to describe the rates of depressive disorders.

Spatial distribution, sediment‒water partitioning, risk assessment and source apportionment of heavy metals in the Golmud River-Dabson Salt Lake ecosystem.

The occurrence of heavy metals is important for understanding their behavior in the sediments of river-salt lake ecosystems due to dramatically changes in salinity and flow velocity at the confluence area. Sediments and surface water samples were collected from the Golmud River-Dabson Salt Lake ecosystem, northwest China, to investigate the spatial distribution, sediment-water partitioning, risk assessment and source apportionment of heavy metals. Higher concentrations of heavy metals were observed in surface water from Dabson Salt Lake than in other regions.

Cordycepin alleviates metabolic dysfunction-associated liver disease by restoring mitochondrial homeostasis and reducing oxidative stress via Parkin-mediated mitophagy.

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) keeps rising with only a few drugs available. The present study aims to investigate the effects and mechanisms of cordycepin on MASLD. Male C57BL/6 mice were induced with a 90-day high-fat diet (HFD) and intraperitoneal administration with streptozotocin to establish MASLD murine model.

Reducing Disorder in PbTe Nanowires for Majorana Research.

Material challenges are the key issue in Majorana research, where surface disorder constrains device performance. Here, we tackle this challenge by embedding PbTe nanowires within a lattice-constant-matched crystal. The wire edges are shaped by self-organized growth instead of lithography, resulting in nearly atomically flat facets along both cross-sectional and longitudinal directions.

Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9.

The intestinal microbiota is a key environmental factor in the development of colorectal cancer (CRC). Here, we report that, in the context of mild colonic inflammation, the microbiota protects against colorectal tumorigenesis in mice. This protection is achieved by microbial suppression of the long non-coding RNA (lncRNA) Snhg9.

The highly allo-autopolyploid modern sugarcane genome and very recent allopolyploidization in Saccharum.

Modern sugarcane, a highly allo-autopolyploid organism, has a very complex genome. In the present study, the karyotype and genome architecture of modern sugarcane were investigated, resulting in a genome assembly of 97 chromosomes (8.84 Gb).

Bithiophene Imide-Based Self-Assembled Monolayers (SAMs) on NiOx for High-Performance Tin Perovskite Solar Cells Fabricated Using a Two-Step Approach.

Three new bithiophene imide (BTI)-based organic small molecules, (), (), and (), with varied alkyl side chains, were developed and employed as self-assembled monolayers (SAMs) applied to NiOx films in tin perovskite solar cells (TPSCs). The NiOx layer has the effect of modifying the hydrophilicity and the surface roughness of ITO for SAM to uniformly deposit on it. The side chains of the SAM molecules play a vital role in the formation of a high-quality perovskite layer in TPSCs.

Electronic Structure Modulation Induced by the Synergy of Cobalt Low-Nuclearity Clusters and Mononuclear Sites for Efficient Oxygen Electrocatalysis.

The development of high-performance bifunctional single-atom catalysts for use in applications, such as zinc-air batteries, is greatly impeded by mild oxygen reduction and evolution reactions (ORR and OER). Herein, we report a bifunctional oxygen electrocatalyst designed to overcome these limitations. The catalyst consists of well-dispersed low-nuclearity Co clusters and adjacent Co single atoms over a nitrogen-doped carbon matrix (Co/NC).

Fast-Charging Solid-State Li Batteries: Materials, Strategies, and Prospects.

The ability to rapidly charge batteries is crucial for widespread electrification across a number of key sectors, including transportation, grid storage, and portable electronics. Nevertheless, conventional Li-ion batteries with organic liquid electrolytes face significant technical challenges in achieving rapid charging rates without sacrificing electrochemical efficiency and safety. Solid-state batteries (SSBs) offer intrinsic stability and safety over their liquid counterparts, which can potentially bring exciting opportunities for fast charging applications.

[Carbon Peak and Carbon Neutrality Scenarios for Key Industries in Jiangsu Province Based on LEAP Model].

In this study, strategies for meeting the carbon peak and carbon neutral targets are developed through an in-depth analysis of future energy demand and carbon emission scenarios in Jiangsu Province. The LEAP model was used to forecast energy demand and carbon emissions under different scenarios from 2021 to 2060. Under the baseline scenario, the energy demand of key industries in Jiangsu Province showed a high rate of growth, with energy consumption increasing by 2.

A risk-based unmanned aerial vehicle path planning scheme for complex air-ground environments.

Multifarious applications of unmanned aerial vehicles (UAVs) are thriving in extensive fields and facilitating our lives. However, the potential third-party risks (TPRs) on the ground are neglected by developers and companies, which limits large-scale commercialization. Risk assessment is an efficacious method for mitigating TPRs before undertaking flight tasks.

Identification and Functional Analysis of Strigolactone Pathway Genes Regulating Tillering Traits in Sugarcane.

Saccharum officinarum (S. officinarum) and Saccharum spontaneum (S. spontaneum) are two fundamental species of modern sugarcane cultivars, exhibiting divergent tillering patterns crucial for sugarcane architecture and yield.

The First Case of Serogroup Y and An Expanded Investigation of Healthy Carriers - Shijiazhuang City, Hebei Province, China, 2023.

What Is Already Known About This Topic?: (Nm) is a bacterial pathogen that causes meningococcal disease. Serogroups A, B, C, W, X, and Y account for the vast majority of cases. However, invasive meningococcal disease (IMD) caused by NmY is rare in China and has been reported only in Tianjin, Guangdong, Shanghai, and Hunan provinces and cities.

Ultra-compact and high-precision differential detection method based on liquid crystal polarization grating for miniature atomic magnetometer.

Atomic magnetometers (AMs) that use alkali vapors, such as rubidium, are among the most sensitive sensors for magnetic field measurement. They commonly use polarization differential detection to mitigate common-mode noise. Nevertheless, traditional differential detection optics, including polarization beam splitters (PBS) and half-wave plates, are typically bulky and large, which restricts further reductions in sensor dimensions.

YK11 promotes osteogenic differentiation of BMSCs and repair of bone defects.

The selective androgen receptor (AR) modulator YK11 promotes the anabolism of muscle cells and osteoblastic precursor cells. However, its effects on bone marrow-derived mesenchymal stem cells (BMSCs) and the repair of cranial bone defects are unknown. Here, the effects of different concentrations of YK11 on the osteogenic differentiation of BMSCs were determined.

Cellular MSI-H score: a robust predictive biomarker for immunotherapy response and survival in gastrointestinal cancer.

Microsatellite instability-high (MSI-H) is a critical biomarker for immunotherapy, yet primary resistance remains a significant challenge. Current MSI-H detection methods evaluate the proportion of MSI-H loci, termed molecular MSI-H score, which can be affected by intratumoral heterogeneity (ITH). To address this limitation, we propose evaluating MSI-H at the cellular level to improve the prediction of immunotherapy outcomes.