H3K4me2 functions as a repressive epigenetic mark in plants.

Background: In animals, H3K4me2 and H3K4me3 are enriched at the transcription start site (TSS) and function as epigenetic marks that regulate gene transcription, but their functions in plants have not been fully characterized.

Results: We used chromatin immunoprecipitation sequencing to analyze the rice genome-wide changes to H3K4me1/H3K4me2/H3K4me3 following the loss of an H3K4-specific methyltransferase, SDG701. The knockdown of SDG701 resulted in a global decrease in H3K4me2/H3K4me3 levels throughout the rice genome.

Changes of second-time mothers and their infants under the universal two-child policy in Changsha, China.

Background: China announced the implementation of the universal two-child policy in Oct, 2015; every couple was allowed to have two children. However, its influences on maternal well-being and infants' outcomes are still to be discovered.

Objectives: To detect influences of the universal two-child policy.

Inverse correlation between Naa10p and Pirh2 expression and the combined prognostic value in oral squamous cell carcinoma patients.

Background: This study aims to explore the associations between N-α-acetyltransferase 10 protein (Naa10p) and p53-induced protein with a RING-H2 domain (Pirh2) expression and clinicopathological characteristics in oral squamous cell carcinoma (OSCC).

Methods: Immunohistochemistry was performed to detect Naa10p and Pirh2 levels containing 118 OSCC specimens, and additional analyses were used to determine correlations between Naa10p and Pirh2 expressions, generate survival curves, and perform univariate and multivariate statistical analyses. Further, quantitative real-time PCR (qRT-PCR) and western blot were employed to examine Naa10p and Pirh2 expression level in OSCC patients' samples.

Publisher Correction: Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring.

In Fig. 4c of this Article, the scale bar units were incorrectly stated as 'μV'; the correct units are 'mV'. The figure has now been amended accordingly.

Chiral BINOL-Based Covalent Organic Frameworks for Enantioselective Sensing.

Covalent organic frameworks (COFs) have emerged as a novel platform for material design and functional explorations, but it remains a challenge to synthetically functionalize targeted structures for task-specific applications. Optically pure 1,1'-bi-2-naphthol (BINOL) is one of the most important sources of chirality for organic synthesis and materials science, but it has not yet been used in construction of COFs for enantioselective processes. Here, by elaborately designing and choosing an enantiopure BINOL-based linear dialdehyde and a tris(4-aminophenyl)benzene derivative or tetrakis(4-aminophenyl)ethene as building blocks, two imine-linked chiral fluorescent COFs with a 2D layered hexagonal or tetragonal structure are prepared.

Publisher Correction: Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring.

In Fig. 4c of this Article originally published, the bottom y axis was incorrectly labelled as 'MRI-ECG (μV)'; the correct label is 'MRI/ECG'. In addition, in Fig.

Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring.

Skin-interfaced medical devices are critically important for diagnosing disease, monitoring physiological health and establishing control interfaces with prosthetics, computer systems and wearable robotic devices. Skin-like epidermal electronic technologies can support these use cases in soft and ultrathin materials that conformally interface with the skin in a manner that is mechanically and thermally imperceptible. Nevertheless, schemes so far have limited the overall sizes of these devices to less than a few square centimetres.

Fabrication of Efficient and Stable Perovskite Solar Cells in High-Humidity Environment through Trace-Doping of Large-Sized Cations.

Solution-processed organic-inorganic lead halide perovskites have shown photovoltaic performance above 23 %, attracting great attention. However, the champion devices require fabrication in a controlled inert/dry atmosphere. The development of highly efficient and stable perovskite solar cells under high-humidity atmosphere conditions for future commercialization is still challenging, especially for CH NH PbI (MAPbI ), which is vulnerable to moisture.

Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice.

Background: Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are reaching global epidemic proportions. Lack of non-invasive diagnostic tools and effective therapies constitute two of the major hurdles for a bona fide treatment and a reversal of NASH progression and/or regression of the disease. Nitro-oleic acid (OA-NO) has been proven effective in multiple experimental models of inflammation and fibrosis.

Recent advances in understanding the roles of T cells in pressure overload-induced cardiac hypertrophy and remodeling.

Pressure overload-induced cardiac hypertrophy and remodeling are not simply mechanical responses to overloaded stress. They also involve participation of various immune cells, especially T cells. In this review, we summarized recent advances in understanding the roles of T cells in this process and the possible mechanisms underlying T cells involvement and modulation.

Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL-induced signaling pathways.

Osteoporosis is a form of osteolytic disease caused by an imbalance in bone homeostasis, with reductions in osteoblast bone formation, and augmented osteoclast formation and resorption resulting in reduced bone mass. Cajaninstilbene acid (CSA) is a natural compound derived from pigeon pea leaves. CSA possesses beneficial properties as an anti-inflammatory, antibacterial, antihepatitis, and anticancer agent; however, its potential to modulate bone homeostasis and osteoporosis has not been studied.

Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice.

Postmenopausal osteoporosis (PMO) is a progressive bone disease characterized by the over-production and activation of osteoclasts in elderly women. In our study, we investigated the anti-osteoclastogenic effect of evodiamine (EVO) in vivo and in vitro, as well as the underlying mechanism. By using an in vitro bone marrow macrophage (BMM)-derived osteoclast culture system, we found that EVO inhibited osteoclast formation, hydroxyapatite resorption and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene and protein expression.

Control Interlayer Stacking and Chemical Stability of Two-Dimensional Covalent Organic Frameworks via Steric Tuning.

Layer stacking and chemical stability are crucial for two-dimensional covalent organic frameworks (2D COFs), but are yet challenging to gain control. In this work, we demonstrate synthetic control of both the layer stacking and chemical stability of 2D COFs by managing interlayer steric hindrance via a multivariate (MTV) approach. By co-condensation of triamines with and without alkyl substituents (ethyl and isopropyl) and a di- or trialdehyde, a family of two-, three-, and four-component 2D COFs with AA, AB, or ABC stacking is prepared.

MicroRNA-140-5p targeting tumor necrosis factor-α prevents pulmonary arterial hypertension.

Background: Pulmonary arterial hypertension (PAH) is characterized by the apoptosis resistance and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Its pathogenesis has not been revealed. Here, we carried out experiments to investigate the functions of miR-140-5p and tumor necrosis factor-α (TNF-α).

Madecassoside inhibits estrogen deficiency-induced osteoporosis by suppressing RANKL-induced osteoclastogenesis.

Osteoporosis is the most common osteolytic disease characterized by excessive osteoclast formation and resultant bone loss, which afflicts millions of patients around the world. Madecassoside (MA), isolated from Centella asiatica, was reported to have anti-inflammatory and antioxidant activities, but its role in osteoporosis treatment has not yet been confirmed. In our study, MA was found to have an inhibitory effect on the RANKL-induced formation and function of OCs in a dose-dependent manner without cytotoxicity.

Corrections for "Bioluminescence Tomography Based on Gaussian Weighted Laplace Prior Regularization for Morphological Imaging of Glioma".

In [1], the affiliation for Y. Gao, K. Wang and J.

Particle size dependence of the physicochemical properties of biochar.

The inadequate definition of different particle sizes of biochar impedes the establishment of guidelines concerning the selection of suitable particle sizes. In this study, various properties of a series of ten biochar samples of varying particle size (5-5000 μm) from the same origin have been investigated and compared. Cluster analysis and principal component analysis based on all of the parameters were executed to evaluate the dissimilarity of different particle sizes of biochar, and to classify the size ranges determining the relevant properties.

Reconstruction method for fluorescence molecular tomography based on L1-norm primal accelerated proximal gradient.

Fluorescence molecular tomography (FMT) has been widely used in preclinical tumor imaging, which enables three-dimensional imaging of the distribution of fluorescent probes in small animal bodies via image reconstruction method. However, the reconstruction results are usually unsatisfactory in the term of robustness and efficiency because of the ill-posed and ill-conditioned of FMT problem. In this study, an FMT reconstruction method based on primal accelerated proximal gradient (PAPG) descent and L1-norm regularized projection (L1RP) is proposed.

MiR-214 is an important regulator of the musculoskeletal metabolism and disease.

MiR-214 belongs to a family of microRNA (small, highly conserved noncoding RNA molecules) precursors that play a pivotal role in biological functions, such as cellular function, tissue development, tissue homeostasis, and pathogenesis of diseases. Recently, miR-214 emerged as a critical regulator of musculoskeletal metabolism. Specifically, miR-214 can mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration, and differentiation.

Corrections to "Bioluminescence Tomography Based on Gaussian Weighted Laplace Prior Regularization for Morphological Imaging of Glioma".

The correct affiliation for Yuan Gao, Kun Wang, and Jie Tian is as follows.

[A summary of hip-preservation surgery based on peri-collapse stage of osteonecrosis of femoral head].

Objective: To summarize surgical procedures of hip-preservation based on peri-collapse stage of osteonecrosis of the femoral head (ONFH).

Methods: The basic points of peri-collapse stage theory was expounded. The related literature on surgical procedures was summarized and analyzed based on the theory.

Histone chaperones play crucial roles in maintenance of stem cell niche during plant root development.

Stem cells in both plant and animal kingdoms reside in a specialized cellular context called the stem cell niche (SCN). SCN integrity is crucial for organism development. Here we show that the H3/H4 histone chaperone CHROMATIN ASSEMBLY FACTOR-1 (CAF-1) and the H2A/H2B histone chaperone NAP1-RELATED PROTEIN1/2 (NRP1/2) play synergistic roles in Arabidopsis root SCN maintenance.

A chromatin loop represses WUSCHEL expression in Arabidopsis.

WUSCHEL (WUS) is critical for plant meristem maintenance and determinacy in Arabidopsis, and the regulation of its spatiotemporal expression patterns is complex. We previously found that AGAMOUS (AG), a key MADS-domain transcription factor in floral organ identity and floral meristem determinacy, can directly suppress WUS expression through the recruitment of the Polycomb group (PcG) protein TERMINAL FLOWER 2 (TFL2, also known as LIKE HETEROCHROMATIN PROTEIN 1, LHP1) at the WUS locus; however, the mechanism by which WUS is repressed remains unclear. Here, using chromosome conformation capture (3C) and chromatin immunoprecipitation 3C, we found that two specific regions flanking the WUS gene body bound by AG and TFL2 form a chromatin loop that is directly promoted by AG during flower development in a manner independent of the physical distance and sequence content of the intervening region.

Preliminary quantitative proteomics analysis in chronic and latent Keshan disease by iTRAQ labeling approach.

Keshan disease is a congestive cardiomyopathy. Dietary selenium deficiency combined with additional stressors are recognized to cause the cardiomyopathies. In this study, clinical condition of individuals with different subtypes including chronic and latent were analyzed.