Preparation of iodine-131 labeled Polyvinyl alcohol-collagen microspheres for radioembolization therapy of liver tumors.

Transarterial radioembolization using radionuclide-labeled microspheres has shown efficacy in the treatment of hepatocellular carcinoma (HCC). In this study, a novel formulation of Polyvinyl alcohol-collagen microspheres (PCMs) with an optimal settling rate is developed. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) analyses confirm that the PCMs have uniform morphology with diameters ranging from 20 to 30 μm.

A p-n heterojunction sonosensitizer for improved sono-immunotherapy via induction of multimodal cell death mechanisms.

Activating a robust immune system is a crucial strategy for combating solid tumors and preventing recurrences. Studies have shown that cuproptosis and the resulting increased reactive oxygen species (ROS) can trigger immunogenic cell death (ICD) and modulate the tumor immune microenvironment, thereby activating systemic immunity. Therefore, for this purpose, it is important to design a multifunctional copper-based nanomaterial.

Shape-Controlled Reversible Li Plating-Stripping for Stable and High-Rate Anode-Free Lithium Metal Batteries.

Anode-free lithium metal batteries are promising toward high-energy-density power sources with low-cost, but their practical applications are challenged by poor cycling stability and low rate capability. Herein, a shape change-free and lithium-free anode that well controls the reversible Li plating-stripping is reported, which is composed of a highly-ordered hollow ZnO matrix with a surface-coated lithium-phosphorus-oxynitride (LiPON) layer. The ZnO matrix supplies sufficient cavities and lithiophilic sites to facilitate uniform Li plating/stripping within the hollow cavity, while the LiPON layer maintains stable solid-electrolyte interphase from mechanical and electrochemical damage.

Enhanced diplopia detection and binocular single vision assessment through virtual reality: A comprehensive study.

This study aimed to develop a novel virtual reality (VR)-based binocular single vision (BSV) testing system for the quantitative assessment of diplopia and to evaluate its diagnostic accuracy and stability through clinical research. We first developed a VR-based BSV testing apparatus (VR-BSVT) using Oculus Quest 2 VR glasses and Unity software. The system provides three parameters for assessing subjects' binocular single vision function, and hence their diplopia: VR-BSVF (Virtual Reality-Based Binocular Single Vision Field area), VR-BSVD (Virtual Reality-Based Binocular Single Vision Distance), and VR-BAR (Virtual Reality-Based Binocular Single Vision Field area ratio).

SNAI2, a potential crossing point between cancer and cardiovascular disease.

Cancer and cardiovascular disease remain the leading causes of morbidity and mortality worldwide, and the two separate disease entities share several similarities and possible interactions. Patients with cancer may have underlying cardiovascular disease, which is often exacerbated by the stress of tumor growth or treatment. At the same time, cardiotoxicity induced by anti-cancer therapies or the malignant process itself can lead to new cardiovascular diseases.

Evaluation of immunological effects of two DNA vaccines against Nocardia seriolae in hybrid snakehead.

Although DNA vaccines hold significant potential, their practical application in aquaculture remains limited. In both mammals and teleost fish, B cells, which recognize antigens and produce antibodies, play an important role in immunity. In this study, B-cell epitopes capable of inducing fish immunity from IS701 family transposase (IS701) and molybdopterin-dependent oxidoreductase (Mol) proteins of Nocardia seriolae were screened.

Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis.

Background: Studies have linked gut microbiome and differentiated thyroid cancer (DTC). However, their causal relationships and potential mediating factors have not been well defined. Our study investigated the causal relationships between the gut microbiome, papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC), as well as the mediating effect of potential blood metabolites, using genetic approaches.

Age-related outcomes of transcatheter aortic valve replacement in patients with pure severe aortic regurgitation.

Background: Transcatheter aortic valve replacement (TAVR) has emerged as the recommended treatment for older patients with pure severe aortic regurgitation (PSAR). However, the efficacy of TAVR in younger patients with aortic regurgitation (AR) remains unclear. This study explored the therapeutic efficacy and safety of TAVR in these two groups and compared their outcomes.

Design and motion analysis of a coal mine robot with variable wheel diameter.

In response to the complex unstructured environment of coal mines, a design scheme for variable wheel diameter robots is proposed. Based on the gear, connecting rod and sliding rail mechanism, a wheel with variable diameter was designed. Through the change in the wheel diameter of the robot, the obstacle-crossing ability and terrain adaptation ability of the robot were improved.

Sex- and metabolic-specific association between cumulative body mass index and incident chronic kidney disease: A prospective community-based cohort study.

Background And Aim: Difference in metabolic status may cause inconsistent association between body mass index (BMI) and chronic kidney disease (CKD) in men and women. This study aimed to quantify sex-specific association between cumulative BMI (cumBMI) and incident CKD by different metabolic status.

Methods And Results: Participants free of CKD from the Kailuan Study were followed biennially from baseline (June 2006 to October 2007) to December 2019.

Anion exchange regulated charge separation engineering in bismuth nanoflowers for sonocatalytic radio-immunotherapy.

Ultrasound and X-ray are considered potential options in cancer therapy due to their superior tissue penetration capabilities. Developing effective radiosensitizers is crucial for advancing cancer treatment as they enhance the effectiveness of radiation and sonodynamic therapies while minimizing their side effects. This study aimed to design a degradable bismuth-based heterojunction BiF-BiO:S-PEG (BFOSP) radiosensitizer using anion-exchange-regulated charge separation engineering.

Prediction of Severe Fever with Thrombocytopenia Syndrome Under Future Climate Scenarios in Chuzhou, China.

Severe fever with thrombocytopenia syndrome (SFTS) poses a significant public health concern in China and has the potential for severe morbidity and mortality. Previous studies on SFTS have focused primarily on analyzing its incidence under existing climate conditions, often overlooking the impacts of future climate change on the disease's distribution. Moreover, the key factors influencing SFTS transmission identified in prior research are limited and lack a comprehensive consideration of multiple environmental and socioeconomic factors in specific regions.

Non-central symmetric 2D bismuth-based perovskites for piezoelectric-enhanced sonodynamic immunotherapy.

Sonodynamic therapy (SDT), an emerging treatment modality, exhibits great potential in cancer therapy owing to its excellent tissue penetration, immune activation ability, and relatively low side effects. The lattice distortion of inorganic perovskite is challenging to control, which leads to an unsatisfactory SDT effect. This study presents a two-dimensional bismuth-based halide perovskite material, MABiCl-PEG (MBCP), with favorable piezoelectric properties, being first applied to tumor sonodynamic immunotherapy.

Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas-Immunotherapy-Mediated Cancer Treatment.

Hydrogen therapy has shown new potential in cancer treatment, particularly in high-pressure and hypoxic areas, where it demonstrates the ability to alter the tumor microenvironment and regulate tumor metabolism. Hydrogen disrupts the mitochondrial function of cancer cells, interferes with their energy metabolism, and ultimately leads to energy depletion and apoptosis. In this study, a sonocatalyst (BPM), is designed to generate hydrogen and oxygen in situ within tumors, further enhancing the therapeutic efficacy.

Association between lipid accumulation products and mortality outcomes in patients with osteoporosis and osteopenia.

Background: Osteoporosis (OP) and osteopenia are metabolic bone disorders associated with increased fragility and fracture risk. While lipid accumulation products (LAP) are emerging as potential markers of metabolic health, their prognostic significance in patients with OP or osteopenia remains unclear. The objective of this study is to elucidate the relationship between lipid accumulation products (LAP) and all-cause as well as cardiovascular mortality in individuals diagnosed with either condition.

Lactate Ameliorates Kainic Acid-Induced Neuroinflammation and Cognitive Impairment via the Chemokine Signaling Pathway in Mice.

Purpose: Lactate, previously considered a metabolic waste product, has been shown to have neuroprotective potential. This study aims to investigate the impact of lactate intervention and its underlying mechanisms on epilepsy.

Methods: HT22 cells were stimulated with glutamate to construct an excitotoxicity cell model.

TaWI12 may be involved in pistillody and leaf cracking in wheat.

TaWI12 is a member of the wound-induced (WI) protein family, which has been implicated in plant stress responses and developmental processes. Wheat (Triticum aestivum L.) is a crucial staple crop upon which human sustenance relies.

p54-Fc-Labeled Gold Nanoparticle-Based Lateral Flow Strip-Assisted Portable Devices for Rapid and Quantitative Point-of-Care Detection of ASFV Antibodies.

In this study, a novel rapid immunochromatographic (IC) test for African swine fever virus (ASFV) antibodies is presented. An immunochromatographic test (IC) is a detection technique that combines membrane chromatography with immunolabeling. This approach saves time for antibody preparation, resulting in a shorter production cycle.

Transcriptomic modifications across the genome and potential hazards of pulmonary fibrosis caused by metal-organic frameworks.

Metal-Organic Frameworks (MOFs) have shown great promise in environmental protection, owing to their exceptional properties including ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. However, emerging evidence from experimental studies indicates that MOFs have side effects on human health due to metal ions doping, resulting in excessive reactive oxygen species (ROS) production, pro-inflammatory responses, and liver fibrosis. In this study, we investigated the impact of MOF-199 on human bronchial epithelial (HBE) cells by using transcriptome sequencing analysis.

Engineering Polar Vortices via Strain Soliton Interactions in Marginally Twisted Multilayer Graphene.

Strain solitons have been widely observed in van der Waals materials and their heterostructures. They can manifest as one-dimensional (1D) wires and quasi-two-dimensional (2D) networks. However, their coexistence within the same region has rarely been observed, and their interplay remains unexplored.

The nuclear matrix stabilizes primed-specific genes in human pluripotent stem cells.

The nuclear matrix, a proteinaceous gel composed of proteins and RNA, is an important nuclear structure that supports chromatin architecture, but its role in human pluripotent stem cells (hPSCs) has not been described. Here we show that by disrupting heterogeneous nuclear ribonucleoprotein U (HNRNPU) or the nuclear matrix protein, Matrin-3, primed hPSCs adopted features of the naive pluripotent state, including morphology and upregulation of naive-specific marker genes. We demonstrate that HNRNPU depletion leads to increased chromatin accessibility, reduced DNA contacts and increased nuclear size.

Research on Stability of Removal Function in Figuring Process of Mandrel of X-Ray-Focusing Mirror with Variable Curvature.

Over the past 30 years, researchers have developed X-ray-focusing telescopes by employing the principle of total reflection in thin metal films. The Wolter-I focusing mirror with variable-curvature surfaces demands high precision. However, there has been limited investigation into the removal mechanisms for variable-curvature X-ray mandrels, which are crucial for achieving the desired surface roughness and form accuracy, especially in reducing mid-spatial frequency (MSF) errors.

Construction of Heterostructured NiS@V-NiFe(III) LDH for Enhanced OER Performance.

The oxygen evolution reaction (OER), which involves a four-electron transfer and slow kinetics, requires an efficient catalyst to overcome the high energy barrier for high-performance water electrolysis. In this paper, a novel NiS@V-NiFe(III) LDH/NF catalyst was prepared via a facile two-step hydrothermal method. The constructed heterostructure of NiS@V-NiFe(III) LDH increases the specific surface area and regulates the electronic structure.

Nuclear Structure, Size Regulation, and Role in Cell Migration.

The nucleus serves as a pivotal regulatory and control hub in the cell, governing numerous aspects of cellular functions, including DNA replication, transcription, and RNA processing. Therefore, any deviations in nuclear morphology, structure, or organization can strongly affect cellular activities. In this review, we provide an updated perspective on the structure and function of nuclear components, focusing on the linker of nucleoskeleton and cytoskeleton complex, the nuclear envelope, the nuclear lamina, and chromatin.

Advances in Drug Delivery Systems for Atopic Dermatitis Treatment.

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus and impaired skin barrier function. Advances in drug delivery systems have transformed AD treatment by enhancing drug stability, bioavailability, and targeted delivery. Drug delivery systems such as liposomes, hydrogels, and microneedles enable deeper skin penetration, prolonged drug retention, and controlled release, reducing side effects and treatment frequency.