Scalable fabrication of freely shapable 3D hierarchical Cu-doped hydroxyapatite scaffolds via rapid gelation for enhanced bone repair.

Critical-sized bone defects present a formidable challenge in tissue engineering, necessitating innovative approaches that integrate osteogenesis and angiogenesis for effective repair. Inspired by the hierarchical porous structure of natural bone, this study introduces a novel method for the scalable production of ultra-long, copper-doped hydroxyapatite (Cu-HAp) fibers, utilizing the rapid gelation properties of guar gum (GG) under controlled conditions. These fibers serve as foundational units to fabricate three-dimensional porous scaffolds with a biomimetic hierarchical architecture.

Methanol as an anti-solvent to improve the low open-circuit voltage of CsPbBr perovskite solar cells prepared with water.

CsPbBr has received more and more attention in the field of optoelectronic devices due to its excellent stability. To address the cost and environmental concerns associated with the use of toxic methanol, water has been explored as a substitute solvent for CsBr in the preparation of CsPbBr perovskite solar cells (PSCs). In this study, we utilized methanol as an anti-solvent of the CsBr/HO solution to regulate the detrimental effects of water on the CsPbBr film and control the crystallization process.

Melatonin inhibits the formation of intraplaque neovessels in ApoE-/- mice via PPARγ- RhoA-ROCK pathway.

Background: According to former research, the atherosclerotic plaque is thought to be aggravated by intraplaque neovessels (IPN) and intraplaque hemorrhage (IPH). Intriguingly, a lower incidence of IPH was found in plaque treated with melatonin. In this study, we attempted to investigate the impact and underlying mechanism regarding the influences of melatonin upon IPN.

Comprehensive Analysis of Gut Microbiota Alteration in the Patients and Animal Models with Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is a common disease of endocrine-metabolic disorder, and its etiology remains largely unknown. The gut microbiota is possibly involved in PCOS, while the association remains unclear. The comprehensive analysis combining gut microbiota with PCOS typical symptoms was performed to analyze the role of gut microbiota in PCOS in this study.

Improvement of the Stability and Optical Properties of CsPbBr QDs.

All-inorganic perovskite quantum dots (CsPbX QDs) (X = Cl, Br, I) have the advantages of adjustable emission position, narrow emission spectrum, high fluorescence quantum efficiency (PLQY), easy preparation, and elevated defect tolerance; therefore, they are widely used in optoelectronic devices, such as solar cells, light-emitting diodes, and lasers. However, their stability still constrains their development due to their intrinsic crystal structure, ionic exchange of surface ligands, and exceptional sensitivity to environmental factors, such as light, water, oxygen, and heat. Therefore, in this paper, we investigate the stability improvement of CsPbX QDs and apply fabricated high-efficiency, stable perovskite QDs to solar cells to improve the performance of the cells further.

In Situ Nanofibrillar Polypropylene-Based Composite Microcellular Foams with Enhanced Mechanical and Flame-Retardant Performances.

With the increasing demand for plastic components, the development of lightweight, high strength and functionalized polypropylene (PP) from a cost-effective and environmentally friendly process is critical for resource conservation. In situ fibrillation (INF) and supercritical CO (scCO) foaming technology were combined in this work to fabricate PP foams. Polyethylene terephthalate (PET) and poly(diaryloxyphosphazene)(PDPP) particles were applied to fabricate in situ fibrillated PP/PET/PDPP composite foams with enhanced mechanical properties and favorable flame-retardant performance.

Lightweight and High Impact Toughness PP/PET/POE Composite Foams Fabricated by In Situ Nanofibrillation and Microcellular Injection Molding.

Polypropylene (PP) has become the most promising and candidate material for fabricating lightweight products. Microcellular injection molding (MIM) is a cost-effective technology for manufacturing porous plastic products. However, it is still challenging to fabricate high-performance PP microcellular components.

Validating the accuracy of a multifunctional smartwatch sphygmomanometer to monitor blood pressure.

Background: Hypertension is the most modifiable factor associated with cardiovascular events and complications. The conventional blood pressure (BP) meter method is simple but is limited in terms of real-time monitoring abnormal BP. Therefore, the development of a multifunction smartwatch (HUAWEI WATCH D) sphygmomanometer could significantly improve integrated BP monitoring.

Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission.

Rational: Excessive mitochondrial fission is considered key process involved in myocardial ischemia/reperfusion (I/R) injury. However, the upstream mechanism remains largely unclear. Decreased level of Kruppel Like Factor 4 (KLF4) has been implicated in the pathogenesis of mitochondrial dysfunction and heart's adaption to stress.

N‑acetyl cysteine prevents ambient fine particulate matter‑potentiated atherosclerosis via inhibition of reactive oxygen species‑induced oxidized low density lipoprotein elevation and decreased circulating endothelial progenitor cell.

Ambient fine particulate matter (PM) serves an important role in the development of cardiovascular disease, including atherosclerosis. Antioxidant N‑acetyl cysteine (NAC) has protective effects in the cardiovascular system. However, it is unknown if NAC prevents PM‑potentiated atherosclerosis in hyperlipidemia.

A Hierarchical Path Planning Approach with Multi-SARSA Based on Topological Map.

In this paper, a novel path planning algorithm with Reinforcement Learning is proposed based on the topological map. The proposed algorithm has a two-level structure. At the first level, the proposed method generates the topological area using the region dynamic growth algorithm based on the grid map.

Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex.

The sex of a patient can affect the outcomes of several cardiovascular diseases, and men generally tend to experience earlier episodes of cardiovascular diseases compared with women. The progression of atherosclerosis during hyperlipidemia can be induced by reactive oxygen species (ROS) and oxidized-low-density lipoprotein (ox-LDL). By contrast, bone marrow (BM)-derived endothelial progenitor cells (EPCs) have been reported to serve a protective role against atherosclerosis.

Does "replacing business tax with value-added tax" promote the energy efficiency of the logistics industry in China?

This paper investigates the relationship between "replacing business tax with value-added tax" (RBTVT) and the total factor energy efficiency (TFEE) of the logistics industry using regression discontinuity (RD) method, and the research shows that the TFEE of the logistics industry in China has presented a benign growth trend. RBTVT has significantly promoted the development of TFEE in the logistics industry, and its influence has mainly stemmed from the improvement of green technology progress. Moreover, the promotion mechanism of policy in the eastern region reacts more sharp than that in the central and western regions does.

Elevated plasma levels of Mac-2 binding protein predict poor cardiovascular outcomes in patients with acute coronary syndrome.

Background: Mac-2 binding protein (M2BP) is an inflammatory glycoprotein associated with carotid atherosclerosis and all-cause mortality in patients with suspected coronary artery diseases. We aimed to explore the potential association of plasma M2BP levels with unstable plaque morphology and cardiovascular outcomes in patients with acute coronary syndrome (ACS).

Patients And Methods: We compared plasma M2BP levels among three groups: 216 patients with ACS, 82 patients with stable angina pectoris, and 50 controls.