A negative-doughnut distal resection margin less than 5 mm does not affect prognosis in rectal cancer.

Aim: Many issues relating to the distal margin of anterior resection of the rectum still exist. We aimed to investigate whether negative distal resection margin (DRM) and positive DRM in the main specimen with negative doughnut has equivalent prognosis in patients with rectal cancer.

Methods: We included 287 patients with rectal cancer, including 69 cases with positive margins and 218 cases with negative margins, all of whom underwent regular follow-up.

Highly-sensitive optical organic vapor sensor through polymeric swelling induced variation of fluorescent intensity.

Traditional optical organic vapor sensors with solvatochromic shift mechanisms have lower sensitivity due to weak intermolecular interactions. Here, we report a general strategy to prepare a higher sensitivity optical organic vapor sensor through polymeric swelling-induced variation of fluorescent intensity. We combine one-dimensional polymeric structures and aggregation-induced emission (AIE) molecules together to form a polymer/AIE microwires array as a sensor.

2D Organic Photonics: An Asymmetric Optical Waveguide in Self-Assembled Halogen-Bonded Cocrystals.

Anisotropic organic molecular construction and packing are crucial for the optoelectronic properties of organic crystals. Two-dimensional (2D) organic crystals with regular morphology and good photon confinement are potentially suitable for a chip-scale planar photonics system. Herein, through the bottom-up process, 2D halogen-bonded DPEpe-F DIB cocrystals were fabricated that exhibit an asymmetric optical waveguide with the optical-loss coefficients of R =0.

Manipulation of Colloidal Particles in Three Dimensions via Microfluid Engineering.

The assembly of nanoparticles into ordered 3D architectures, which requires more complex spatial arrangements of nanoparticles than 2D, is essential to develop new nano- or microdevices in the fields of biotechnology, magnetic devices, catalysis, and optoelectronics. However, because of the long-distance interactions among the nanoparticles or the applied external force, the movement of nanoparticles cannot be precisely controlled, particularly in multidimensional architectures. Therefore, controlling the 3D architecture remains challenging.

Patterning of Discotic Liquid Crystals with Tunable Molecular Orientation for Electronic Applications.

The large-area formation of functional micropatterns with liquid crystals is of great significance for diversified applications in interdisciplinary fields. Meanwhile, the control of molecular alignment in the patterns is fundamental and prerequisite for the adequate exploitation of their photoelectric properties. However, it would be extremely complicated and challenging for discotic liquid crystals (DLCs) to achieve the goal, because they are insensitive to external fields and surface chemistry.

Enhanced osteogenic differentiation and bone regeneration of poly(lactic-co-glycolic acid) by graphene via activation of PI3K/Akt/GSK-3β/β-catenin signal circuit.

The reconstruction of bone defects by guiding autologous bone tissue regeneration with artificial biomaterials is a potential strategy in the area of bone tissue engineering. The development of new polymers with good biocompatibility, favorable mechanical properties, and osteoinductivity is of vital importance. Graphene and its derivatives have attracted extensive interests due to the exceptional physiochemical and biological properties of graphene.

Pharmacological Review on Asiatic Acid and Its Derivatives: A Potential Compound.

Natural triterpenes represent a group of pharmacologically active and structurally diverse organic compounds. The focus on these phytochemicals has been enormous in the past few years, worldwide. Asiatic acid (AA), a naturally occurring pentacyclic triterpenoid, is found mainly in the traditional medicinal herb Centella asiatica.

High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions.

Polymeric micelles are extensively used for the delivery of hydrophobic drugs, which, however, suffer from unsatisfactory drug loading, colloidal uniformity, formulation stability, and drug release. Herein, we demonstrate a convenient strategy to prepare micelles with ultrahigh drug loading via the incorporation of polymer-drug coordination interactions. An amphiphilic copolymer containing pendant phenylboronic acid as electron acceptor unit was synthesized, which afforded donor-acceptor coordination with doxorubicin to obtain micelles with ultrahigh drug loading (∼50%), nearly quantitative loading efficiency (>95%), uniform size, and colloidal stability.

Interstitial pneumonitis during rituximab-containing chemotherapy for primary central nervous system lymphomas: a case report and review of literature.

Background: Primary central nervous system lymphoma(PCNSL) is a rare kind of non-Hodgkin lymphoma. Rituximab combined with high-dose methotrexate, cytarabine and dexamethasone (R-MAD regimen) were reported effective for PCNSL patients. Rituximab can cause several side effects, including fever, chills and rigors.

Association between Internet gaming disorder and generalized anxiety disorder.

Introduction This study evaluates the association between generalized anxiety disorder (GAD) and Internet gaming disorder (IGD) and the role of behavior inhibition in young adults. Methods We recruited 87 people with IGD and a control group of 87 people without a history of IGD. All participants underwent a diagnostic interview based on the fifth edition of Diagnostic and Statistical Manual of Mental Disorders, IGD and GAD criteria, and completed a questionnaire on behavior inhibition, depression, and anxiety.

Regular Aligned 1D Single-Crystalline Supramolecular Arrays for Photodetectors.

Solution-processed semiconductor single-crystal patterns possess unique advantages of large scale and low cost, leading to potential applications toward high-performance optoelectronic devices. To integrate organic semiconductor micro/nanostructures into devices, various patterning techniques have been developed. However, previous patterning techniques suffer from trade-offs between precision, scalability, crystallinity, and orientation.

Temporary Diverting Stoma Improves Recovery of Anastomotic Leakage after Anterior Resection for Rectal Cancer.

Temporary diverting stoma might be a protective factor for the prevention of anastomotic leakage (AL) after anterior resection. Its role in leakage recovery is unknown. This study aimed to evaluate the effect of temporary diverting stoma on anastomotic leakage severity and recovery.

Solution Adsorption Formation of a π-Conjugated Polymer/Graphene Composite for High-Performance Field-Effect Transistors.

Semiconducting polymers with π-conjugated electronic structures have potential application in the large-scale printable fabrication of high-performance electronic and optoelectronic devices. However, owing to their poor environmental stability and high-cost synthesis, polymer semiconductors possess limited device implementation. Here, an approach for constructing a π-conjugated polymer/graphene composite material to circumvent these limitations is provided, and then this material is patterned into 1D arrays.

Rectovaginal fistula after low anterior resection in Chinese patients with colorectal cancer.

Rectovaginal fistula is a postoperative complication of low anterior resection. We investigated the incidence of rectovaginal fistula (RVF) after low anterior resection, its risk factors and its optimal treatment. We analyzed data from 1,493 female patients who underwent low anterior resection for colorectal cancer between January 2006 and March 2016.

Large-Scale, Long-Range-Ordered Patterning of Nanocrystals via Capillary-Bridge Manipulation.

Deterministic assembly of nanoparticles with programmable patterns is a core opportunity for property-by-design fabrication and large-scale integration of functional materials and devices. The wet-chemical-synthesized colloidal nanocrystals are compatible with solution assembly techniques, thus possessing advantages of high efficiency, low cost, and large scale. However, conventional solution process suffers from tradeoffs between spatial precision and long-range order of nanocrystal assembly arising from the uncontrollable dewetting dynamics and fluid flow.

Predicting the HMA-LMA Status in Marine Sponges by Machine Learning.

The dichotomy between high microbial abundance (HMA) and low microbial abundance (LMA) sponges has been observed in sponge-microbe symbiosis, although the extent of this pattern remains poorly unknown. We characterized the differences between the microbiomes of HMA ( = 19) and LMA ( = 17) sponges (575 specimens) present in the Sponge Microbiome Project. HMA sponges were associated with richer and more diverse microbiomes than LMA sponges, as indicated by the comparison of alpha diversity metrics.

Comparative study of single-center patients with thyroid metastases from colorectal cancer and previously reported cases in the literature.

Background: Thyroid metastases from colorectal cancer (CRC) are rare, both in clinical practice and in the literature; hence, their diagnosis, appropriate treatment, and prognostic factors require further investigations.

Methods: A retrospective analysis was performed for four cases of thyroid metastases from CRC, treated in our center between January 2005 and December 2015, and the relevant literature was searched using PubMed, resulting in the identification of 17 patients with detailed information available. The clinical data and follow-up information of our patients and the previously reported cases were collected and compared.

Is there a prognostic value of tumor location among Chinese patients with colorectal cancer?

Differences in epidemiology, pathological features, and molecular pathogeneses have been observed according to primary tumor location in colorectal cancer (CRC). However, predicting CRC survival by tumor location remains controversial. Therefore, we compared the pathological characteristics, molecular features, and prognoses of right-side colon cancer (RCC), left-side colon cancer (LCC), and rectal cancer (RECC) among Chinese patients with CRC.

Crystallographically Aligned Perovskite Structures for High-Performance Polarization-Sensitive Photodetectors.

Polarization-sensitive perovskite photodetectors are realized by crystallographically aligning 1D perovskite arrays. High-quality inorganic perovskite single crystals with crystallographic order are fabricated by strictly manipulating the dewetting process of organic solution, yielding photodetectors with high photoresponsivity and fast response speed.

CapOX as neoadjuvant chemotherapy for locally advanced operable colon cancer patients: a prospective single-arm phase II trial.

Objective: The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy (NAC) using oxaliplatin plus capecitabine (CapOX) for patients with operable locally advanced colon cancer (CC).

Methods: Patients with computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, patients were treated with at least 2 cycles of NAC consisting of 130 mg/m oxaliplatin on d 1, plus 1,000 mg/m capecitabine twice daily for 14 d every 3 weeks, followed by surgery, and then with the rest cycles of adjuvant chemotherapy.

Data on the effect of boiling on the organosulfides and the hydrogen sulfide-releasing activity of garlic.

This article contains experimental data on the identification and quantification of the organosulfides on boiled garlic extracts. Data included are related to the research article "" (R. Tocmo, Y.

Boiling enriches the linear polysulfides and the hydrogen sulfide-releasing activity of garlic.

Garlic is rich in polysulfides, and some of them can be HS donors. This study was conducted to explore the effect of cooking on garlic's organopolysulfides and HS-releasing activity. Garlic bulbs were crushed and boiled for a period ranging from 3 to 30min and the solvent extracts were analyzed by GC-MS/FID and HPLC.

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict chemotherapy outcomes and prognosis in patients with colorectal cancer and synchronous liver metastasis.

Background: Recent evidence indicates that inflammatory parameters could be useful to predict metastasis from colorectal cancer. However, their roles in predicting chemotherapy response and prognosis in patients with synchronous colorectal liver metastasis (CLM) are unknown.

Methods: The clinical data and baseline laboratory parameters of 55 patients with synchronous CLM were retrospectively reviewed.

"Capillary-Bridge Lithography" for Patterning Organic Crystals toward Mode-Tunable Microlaser Arrays.

A versatile "capillary-bridge lithography" technique is developed for patterning 1D organic single crystals and microring structures through controlling the generation and dewetting of capillary bridges on an interface with asymmetric wettability. High-performance Fabry-Pérot and whispering-gallery mode lasing emission with tunable modes are achieved on these 1D and microring structures.

Valproic Acid and Lithium Meditate Anti-Inflammatory Effects by Differentially Modulating Dendritic Cell Differentiation and Function.

Valproic acid (VPA), with inhibition activity mainly toward histone deacetylase (HDAC) and Glycogen Synthase Kinase (GSK)-3, and lithium, with inhibition activity mainly toward GSK-3, are both prescribed in clinical as mood-stabilizers and anticonvulsants for the control of bipolar disorder. This study aims to compare the immuno-modulation activities of VPA and lithium, especially on the differentiation and functions of dendritic cells (DC). Our data show that treatment with VPA or lithium effectively alleviated the severity of collagen-induced arthritis triggered by LPS in mice.