Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury.

The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using overexpression and knockdown constructs. Activation of the Notch signaling pathway by Notch1 or Jagged1 overexpression enhanced the migration, invasiveness and angiogenic ability of endothelial progenitor cells.

[Formalin inflammatory pain induced hippocampal neuronal apoptosis of rats].

Aim: To investigate whether formalin inflammatory pain can induce hippocampal neuronal apoptosis of rats or not.

Methods: Rats were subcutaneously injected with 0.2 ml 0.