The chromatin accessibility and 3D high-order structure play an important role in gene expression and regulation, and are involved in numerous cellular processes such as differentiation, development and tumorigenesis. It is currently one of the hottest research fields in epigenetics. The animal embryonic development initiates from the terminally differentiated mature eggs, which are fertilized by sperms to establish totipotent zygotes.
View Article and Find Full Text PDFObjective: To investigate the effects of methylprednisolone pretreatment on pulmonary lung permeability index and the content of the pulmonary surfactant dipalmitoylphosphatidylcholine (DPPC) in a rabbit model of reexpansion pulmonary edema.
Methods: Twenty-one male New Zealand white rabbits were randomly divided into control group, reexpansion, and reexpansion+methylprednisolone pretreatment groups. The rabbit model of reexpansion pulmonary edema was established using Sakaos method.
During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy.
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