Efficient and Robust Parameter Optimization of the Unitary Coupled-Cluster Ansatz.

The variational quantum eigensolver (VQE) framework has been instrumental in advancing near-term quantum algorithms. However, parameter optimization remains a significant bottleneck for VQE, requiring a large number of measurements for successful algorithm execution. In this paper, we propose sequential optimization with approximate parabola (SOAP) as an efficient and robust optimizer specifically designed for parameter optimization of the unitary coupled-cluster ansatz on quantum computers.

Effects of target tree management on understory regeneration in plantations.

To clarify the effects of target tree management on natural forest regeneration, with plantations in the low mountainous regions of eastern Sichuan with target tree densities of 100, 150 and 200 trees·hm as test object, we analyzed the effects of management densities on canopy structure, plant diversity, and soil physicochemical properties on understory regeneration. The results showed that the regeneration index increased with management density, which increased 0.08-0.

TenCirChem: An Efficient Quantum Computational Chemistry Package for the NISQ Era.

TenCirChem is an open-source Python library for simulating variational quantum algorithms for quantum computational chemistry. TenCirChem shows high-performance in the simulation of unitary coupled-cluster circuits, using compact representations of quantum states and excitation operators. Additionally, TenCirChem supports noisy circuit simulation and provides algorithms for variational quantum dynamics.

A metal-poor star with abundances from a pair-instability supernova.

The most massive and shortest-lived stars dominate the chemical evolution of the pre-galactic era. On the basis of numerical simulations, it has long been speculated that the mass of such first-generation stars was up to several hundred solar masses. The very massive first-generation stars with a mass range from 140 to 260 solar masses are predicted to enrich the early interstellar medium through pair-instability supernovae (PISNe).

New Pyridine-Bridged Ferrocene-Rhodamine Receptor for the Multifeature Detection of Hg in Water and Living Cells.

A challenge in the design of optical and redox-active receptors is how to combine a specific recognition center with an efficient responsive system to facilely achieve multifeature detection in biological and environmental analyses. Herein, a novel ferrocene-rhodamine receptor conjugated with a pyridine bridge was designed and synthesized. This receptor can sensitively sense Hg in aqueous media via chromogenic, fluorogenic, and electrochemical multisignal outputs with a low detection limit and fast response time.

Small intestinal bacterial overgrowth is associated with Diarrhea-predominant irritable bowel syndrome by increasing mainly abundance.

Diarrhea-predominant irritable bowel syndrome (IBS-D) is the main subtype of IBS, a chronic functional gastrointestinal disorder. Small intestinal bacterial overgrowth (SIBO), which is characterized by dysbiosis of the bowel, causes gastrointestinal symptoms quite similar to IBS-D. However, whether SIBO correlates with IBS-D and its further mechanism remain unknown.

Angiopoietin-1 Promotes the Integrity of Neovascularization in the Subcutaneous Matrigel of Type 1 Diabetic Rats.

Objective: This study aimed to investigate the effects of Ang-1 on neovascularization of diabetic organs by subcutaneous Matrigel angiogenesis model, established in type 1 diabetic rats.

Methods: Ang-1 adenoviral vector was constructed. The rat model was established by STZ and divided into four group.

Fecal Microbiota Transplantation Ameliorates Experimentally Induced Colitis in Mice by Upregulating AhR.

Ulcerative colitis (UC) is a chronic non-specific inflammatory disease that occurs in the colon and rectum. While fecal microbiota transplantation (FMT) is gaining attention as a clinical treatment of UC, the molecular mechanisms behind this effect have yet to be fully understood. A C57BL/6 mouse model was established to test whether FMT promotes the recovery of colon inflammation.

[Fine root morphology and chemistry characteristics in different branch orders of Castanopsis platyacantha and their responses to nitrogen addition].

Fine root morphology and chemistry characteristics of dominant species Castanopsis platya-cantha in an evergreen broad-leaved forest in subtropical China and their response to nitrogen (N) addition were determined in order 1st to 5th. With the increase of root order, C. platyacantha root diameter, tissue density (RTD), and K content increased, and specific root length (SRL), speci-fic surface area (SRA) and contents of N, P and Mg decreased.

Epigenetic restriction of Hippo signaling by MORC2 underlies stemness of hepatocellular carcinoma cells.

The evolutionarily conserved Hippo signaling pathway is a key regulator of stem cell self-renewal, differentiation, and organ size. While alterations in Hippo signaling are causally linked to uncontrolled cell growth and a broad range of malignancies, genetic mutations in the Hippo pathway are uncommon and it is unclear how the tumor suppressor function of the Hippo pathway is disrupted in human cancers. Here, we report a novel epigenetic mechanism of Hippo inactivation in the context of hepatocellular carcinoma (HCC).

Oxidative coupling of sp and sp carbon-hydrogen bonds to construct dihydrobenzofurans.

Metal-catalyzed cross-couplings provide powerful, concise, and accurate methods to construct carbon-carbon bonds from organohalides and organometallic reagents. Recent developments extended cross-couplings to reactions where one of the two partners connects with an aryl or alkyl carbon-hydrogen bond. From an economic and environmental point of view, oxidative couplings between two carbon-hydrogen bonds would be ideal.

Combined effects off indomethacin and oxaliplatin on lymph node metastasis related factors in human lung cancerxenografts in nude mice.

To investigate the combined effects of indomethacin and oxaliplatin on expressions of epidermal growth factor receptor (EGFR), E-cadherin (E-cad), intercellular adhesion molecule-1 (ICAM-1) and CD44v6 related to lymph node metastasis of human lung cancer cell lines. Human lung adenocarcinoma A549 cells were inoculated subcutaneously into the left armpit of nude mice to establish human lung cancer xenografts. The mice were randomly divided into control group, indomethacin group, oxaliplatin group and combination therapy group, which were treated with sterile distilled water, indomethacin, oxaliplatin and indomethacin combined with oxaliplatin, respectively.

Symmetry reduction and boundary modes for Fe chains on an s-wave superconductor.

We investigate the superconducting phases and boundary modes for a quasi-1D system formed by up to three Fe chains on an s-wave superconductor, motivated by a recent experiment. While the Rashba type spin-orbit coupling together with a magnetic ordering is necessary to drive the system to be of nontrivial topology, we show that the onsite [Formula: see text] spin-orbit term, inter-chain diagonal hopping couplings, and magnetic disorders in the Fe chains are crucial in determining the symmetry classes of superconducting phases, which can be topologically trivial or nontrivial in different parameter regimes. In general multiple low-energy Andreev bound states, as well as a single Majorana zero mode if the phase is topological, are obtained in the ends of Fe chains.

Chinese herbal medicine Xiaoji decoction inhibited growth of lung cancer cells through AMPKα-mediated inhibition of Sp1 and DNA methyltransferase 1.

Ethnopharmacological Relevance: Xiaoji decoction (XJD), which was considered as a Chinese herbal prescription, has been used for cancer treatment, especially lung cancer, for decades to improve quality of life and prolong the patient survival. However, the molecular mechanisms underlying the therapeutic potential have not been well elucidated.

Materials And Methods: The cell viability was examined by MTT assays.

Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells.

Background: Ursolic acid (UA), a pentacyclic triterpenoid, is known to have anti-tumor activity in various cancers including human non small cell lung cancer (NSCLC). However, the molecular mechanisms underlying the action of UA remain largely unknown.

Methods: Cell viability was measured by MTT assays.

Combined therapeutic effect and molecular mechanisms of metformin and cisplatin in human lung cancer xenografts in nude mice.

Objective: This work was aimed at studying the inhibitory activity of metformin combined with the commonly used chemotherapy drug cisplatin in human lung cancer xenografts in nude mice. We also examined the combined effects of these drugs on the molecular expression of survivin, matrix metalloproteinase-2 (MMP-2), vascular endothelial growth factor-C (VEGF-C), and vascular endothelial growth factor receptor-3 (VEGFR-3) to determine the mechanism of action and to explore the potential applications of the new effective drug therapy in lung cancer.

Materials And Methods: The nude mice model of lung cancer xenografts was established, and mice were randomly divided into the metformin group, the cisplatin group, the metformin + cisplatin group, and the control group.

Remodeling of rat pulmonary artery induced by chronic smoking exposure.

Objective: To evaluate the dominant role in rat pulmonary artery (PA) remodeling induced by chronic smoking exposure (CSE).

Methods: Thirty-five male Sprague-Dawley (SD) rats were exposed to 36 cigarettes per day, 6 days per week, for 1, 3, or 5 months. Another 35 SD rats were sham-exposed during the same period.

[Cigarette smoke exposure induced pulmonary artery pressure increase through inhibiting Kv1.5 and Kv2.1 mRNA expression in rat pulmonary artery smooth muscles].

Objective: To investigate the effect of cigarette smoke exposure on Kv1.5 and Kv2.1 mRNA expression in rat pulmonary arterial smooth muscle cells (PASMCs), and further to clarify the possible mechanism of cigarette smoking induced pulmonary arterial hypertension.

[Initial RAPD analysis of Isatis indigotica somatic clones' resistance to root rot disease].

Objective: To make initial identification on Isatis Indigotica Somatic Clones' resistant mutant.

Methods: The resistant plants were selected under the treatment of root-rot disease crude toxin. The DNA of the same clones and their parents were analysed by RAPD technology.

[Effect of position of artificial occlusal interference on mandible moving track during lateral movement].

Purpose: To evaluate the effect of position of occlusal interference on the track of mandibular incisal point during lateral movement.

Methods: The changes of track of mandibular incisal point along with the changing of occlusal interference position were recorded by Arcus DigMa mandibular moving track analysis system. The relativity between occlusal interference position and mandibular incisal point moving track on arrowy axis, vertical axis and horizontal axis was analyzed.

[Effect of position of artificial occlusal interference on mandible moving track during protrusive movement].

Purpose: The purpose of this study was to observe the effect of position of occlusal interference on track of mandibular incisal point during protrusive movement.

Methods: The changes of track of mandibular incisal point along with the changing of occlusal interference position were recorded by Arcus DigMa mandibular moving track analysis system. The relativity between occlusal interference position and mandibular incisal point moving track on arrowy axis, vertical axis and horizontal axis was analyzed.

[Detection of masticatory muscle in bilateral distal-extension partially edentulous patients before and after prosthetic rehabilitation by surface electromyography].

Purpose: To analyze the difference of masticatory muscle in bilateral distal-extension partially edentulous patients before and after prosthetic rehabilitation by surface electromyography.

Methods: Twenty-seven bilateral distal-extension partially edentulous patients were randomly selected, and be detected before and after prosthetic rehabilitation by surface electromyography. During the detection, the amplitudes of the anterior temporalis and masseter muscle were registered.

[The effect of the position of artificial premature on mandible moving track during opening movement].

Purpose: The purpose of this study was to observe the effect of the position of premature on track of mandibular incisal point during opening movement.

Methods: The changes of the track of mandibular incisal point along with the change of premature position were recorded by Arcus DigMa mandibular moving track analysis system. The relativity between the premature position and mandibular incisal point moving track on arrowy axis, vertical axis and horizontal axis was analyzed.