Publications by authors named "Yu-ping Lin"
: Despite considerable literature supporting the benefit of dietary interventions in individuals with type 2 diabetes mellitus (T2DM) and overweight/obesity, which diet works best is currently unknown. We conducted a systematic review and network meta-analysis (NMA) to evaluate the comparative effectiveness of different dietary approaches in overweight or obese adults with T2DM. : We searched EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL) and PubMed up till July 2023 for controlled studies using different dietary approaches.
View Article and Find Full Text PDFArticle Synopsis
- Dyslexia and developmental language disorders are significant learning challenges, but their genetic origins are largely unknown, with previous studies focused mainly on Europeans.
- This research conducted a genome-wide association study (GWAS) on 34 reading and language-related traits in Hong Kong Chinese bilingual children, involving a total of 1,046 participants, including twins and singletons.
- Five independent genetic loci were found to be significantly linked to various language and literacy skills, indicating a genetic basis for both Chinese and English abilities, with connections to educational attainment and cognitive performance.
Article Synopsis
- The study aimed to assess the effectiveness and safety of foot baths using Tangbi Waixi Decoction for patients with diabetic peripheral neuropathy (DPN) through a multicenter double-blinded randomized controlled trial.
- A total of 632 patients participated, receiving either a high or low dose of herbal treatment for two weeks, with results showing improvements in nerve function and reduced pain scores in both groups after 12 weeks.
- However, the lower dose was found to be more effective than the higher dose, and overall, there were no significant differences in adverse events between the treatment and control groups, indicating the treatment was safe.
Article Synopsis
- * A recent study claimed that all LCCBs, including dihydropyridines, increase the risk of heart failure, but the researchers faced criticism regarding their methodology and the impact of confounding factors such as age and health conditions.
- * In response, the authors of this paper highlight flaws in the previous study's design and calculations, asserting that their results contradict the conclusions of Johnson et al., thus reaffirming the safety of dihydropyridines like amlodipine regarding heart failure
Article Synopsis
- Radiotherapy (RT) is a local treatment option for patients with refractory or relapsed aggressive B-cell lymphomas, but the effectiveness of hypofractionated RT had not been previously confirmed.
- A study analyzed 30 patients who received hypofractionated RT, showing a high objective response rate (90%) and complete response rate (80%), with promising one-year overall survival (81.8%) and progression-free survival (66.3%).
- The findings indicate that hypofractionated RT is both effective and tolerable, particularly for patients with localized residual disease, as no serious side effects were reported.
Article Synopsis
- The study investigates the effects of SA, a plant extract from southwestern China, on the gut microbiota and metabolic regulation in rats with non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD).
- SA treatment significantly reduced body weight, lipid levels, and inflammation while inhibiting various inflammatory markers related to the NLRP3 signaling pathway.
- Analysis demonstrated that SA improved gut microbiota diversity and altered microbial composition, identifying 24 key metabolites that may play a role in restoring metabolic balance in NASH rats.
Article Synopsis
- * In a randomized controlled trial involving 156 patients, the intervention group received a comprehensive self-management booklet, skill training, and follow-up calls, while the control group only received health education leaflets.
- * Results showed significant improvements in anxiety, depression, fatigue, and quality of life over time for the intervention group, but no changes were noted in physical activity or dietary habits, suggesting that self-management skills can greatly aid in cancer survivorship.
Background: Fighting against the COVID-19 pandemic, front-line nurses were under unprecedented psychological pressure. Therefore, it is necessary to promptly evaluate the psychological status of nurses during the COVID-19 epidemic period.
Aim: To investigate nurses' mental health during the COVID-19 pandemic, and to test the mediating role of social support and psychological resilience between coping and mental health.
Article Synopsis
- - Tylophora yunnanensis Schltr (TYS) is traditionally used in China to treat liver diseases like hepatitis, though its exact mechanism is not well understood.
- - This study investigates how TYS affects gut microbiota and metabolites in non-alcoholic steatohepatitis (NASH) rats, aiming to reduce NLRP3 activation, which is linked to inflammation.
- - Results indicated that TYS improved NASH symptoms by reducing body weight, lipid levels, and inflammation markers, while also enhancing gut microbiota diversity and changing its composition.
Background: Nonalcoholic steatohepatitis (NASH) is among the most common liver diseases in the world. Flavonoids from Scutellaria amoena (SAF) are used in the treatment of hepatopathy in China. However, the effect and mechanism against NASH remain unclear.
View Article and Find Full Text PDFArticle Synopsis
- * A study investigated Dap.'s effectiveness against atopic dermatitis (AD) and allergic asthma through various animal and cell experiments, including inducing AD-like lesions in mice and creating asthma models.
- * Results showed that Dap. significantly reduced AD-like symptoms, inflammation, and levels of various immune-related cytokines and antibodies, indicating its potential as a therapeutic option for these conditions.
Article Synopsis
- AKAP79 is a scaffolding protein that organizes key signaling molecules at the plasma membrane, enabling the activation of the transcription factor NFAT1 upon calcium store depletion.
- The interaction between AKAP79 and Orai1 channels is relatively brief, allowing free AKAP79, along with calcineurin and NFAT1, to quickly replace AKAP79 on Orai1.
- The study suggests that the recycling of inactive NFAT1 from the cytoplasm to AKAP79, combined with the weak interaction with Orai1, helps sustain long-term signaling and excitation-transcription coupling, and a mathematical model was developed to simulate NFAT dynamics.
Article Synopsis
- This study aimed to assess the effectiveness and safety of flavonoid-containing supplements in preventing acute respiratory tract infections (ARTIs) through a systematic review and meta-analysis of randomized controlled trials (RCTs).
- The analysis included 20 RCTs involving 4,521 participants, which showed significant reductions in both ARTI incidence and the average number of sick days among those taking flavonoid supplements compared to a control group.
- While supplements demonstrated benefits in reducing ARTI occurrences, the study found no significant changes in certain bio-immune markers related to inflammation and immune response.
Article Synopsis
- * The analysis included 25 randomized controlled trials (RCTs) with nearly 2,000 participants, revealing significant reductions in HOMA-IR (a measure of insulin sensitivity) for those taking flavonoid supplements, especially those with mixed flavonoids.
- * Secondary outcomes showed that other metabolic factors like fasting blood glucose, cholesterol, and body weight were also positively affected by flavonoid supplements without notable adverse effects.
Article Synopsis
- Yi medicine Shekaqi is recognized for its diverse pharmacological benefits and effectiveness as traditional ethnic medicine.
- Researchers isolated two new flavonoids and six known flavonoids from Shekaqi, determining their structures using spectral analysis.
- The extracted compounds demonstrated strong in vitro lipid-lowering activities, effectively reducing both total cholesterol and triglyceride levels induced by lipopolysaccharides (LPS).
Background: Prevalence rates of hyperuricemia and gout are increasing. Clinical investigations of hyperuricemia-related risk factors aid in the early detection, prevention, and management of hyperuricemia and gout. Ongoing research is examining the association of obesity, dietary patterns, and blood pressure (BP) with serum uric acid (sUA).
View Article and Find Full Text PDFBackground And Purpose: We aimed to explore the necessity of the external iliac lymph nodes (EIN) along with inguinal nodes (IN) region in clinical target volume (CTV) for rectal carcinomas covering the anal canal region.
Materials And Methods: This research premise enrolled 399 patients who had primary low rectal cancer detected below the peritoneal reflection via magnetic resonance imaging (MRI) and were treated with neoadjuvant radiotherapy (NRT), without elective EIN along with IN irradiation. We stratified the patients into two groups based on whether the lower edge of the rectal tumor extended to the anal canal (P group, n = 109) or not (Rb group, n = 290).
Article Synopsis
- - This meta-analysis examined the effectiveness and safety of flavonoids for treating various viral acute respiratory tract infections (ARTIs) by reviewing randomized controlled trials (RCTs) and analyzing symptom scores and adverse effects.
- - The study included 30 RCTs with over 5,000 participants, showing that flavonoids significantly reduced symptoms and duration of illness in conditions like the common cold, influenza, COVID-19, and acute bronchitis compared to control groups.
- - Results showed notable improvements for flavonoids in multiple areas, including decreased hospitalization rates, symptom severity scores, and recovery times across several respiratory conditions, demonstrating their potential benefits.
To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca nanodomain is a spatially confined signal that arises near open Ca channels. Ca nanodomains near store-operated Orai1 channels stimulate the protein phosphatase calcineurin, which activates the transcription factor NFAT1, and both enzyme and target are initially attached to the plasma membrane through the scaffolding protein AKAP79.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the prevalence of type C behavior in breast cancer patients undergoing postoperative chemotherapy, finding that 28% showed this cancer-prone behavior.
- It identified factors associated with type C behavior, such as age (higher in those 45-59), coping styles (those using resignation were more likely), and societal influences (less common in employed patients and those with strong social support and hope).
- The findings suggest that healthcare professionals can help reduce type C behavior by promoting positive coping mechanisms and enhancing social support, especially for specific at-risk groups.
Article Synopsis
- Current genome-wide association studies (GWAS) generally focus on single diseases, but many individuals experience multiple comorbid conditions, prompting the need for more complex study designs.
- The researchers created a new statistical framework called CombGWAS to analyze genetic susceptibility for comorbid disorders using existing GWAS data, allowing for the investigation of multiple traits simultaneously.
- Their findings revealed numerous genetic risk loci associated with both comorbidities and disease subtypes, indicating that some conditions may have distinct biological characteristics and differing causal relationships to health complications.
Article Synopsis
- Eukaryotic cells strategically compartmentalize second messengers to prevent unwanted signaling outcomes, with calcium (Ca) nanodomains playing a key role in this process.
- The study highlights how the calcium channel Orai1 interacts with the scaffolding protein AKAP79 to activate the transcription factor NFAT1, a crucial mechanism for targeted gene expression.
- Additionally, the research identifies specific regions on Orai1 necessary for this interaction and demonstrates that interfering with this interaction can reduce cytokine production, providing insights for developing immunosuppressant therapies.
Article Synopsis
- The study aimed to understand the health self-management experiences and support needs of colorectal cancer patients after surgery, highlighting its importance for improving their quality of life and survival.
- Using phenomenology, researchers conducted in-depth interviews with ten patients to gather rich insights, identifying three main themes related to their self-management experiences.
- Findings revealed that patients sought support during discomfort, adapted to life changes, and maintained a positive outlook, emphasizing their resilience and the need for continuous adjustment in managing their health post-surgery.
Aims And Objectives: To observe the psychological status of pregnant women during COVID-19 pandemic, and to test a hypothetical model that estimates the influence of psychological response to COVID-19 and security sense on pregnancy stress.
Background: COVID-19 advanced rapidly and then spread worldwide. Pregnant women were more susceptible to the COVID-19 infection.
(Nees) Kuntze is a Chinese herbal medicine used in the treatment of respiratory virus infections. The methanol extract of leaf contains chemical components such as β-sitosterol, indirubin, tryptanthrin, betulin, indigodole A, and indigodole B that have diverse biological activities. However, the antiviral action of leaf and its components against human coronavirus remains to be elucidated.
View Article and Find Full Text PDF