Preparation of antibacterial cellulose nanocrystals-graft-poly[2-(tert-butylamino) ethyl methacrylate] nanoparticles and their applications on creating wound dressings with a bacterial shielding property.

Bacterial infections in wounds, especially in patients with chronic conditions like diabetic wounds, pose significant treatment challenges. Addressing the susceptibility to infection is crucial, and the development of functional dressings to prevent bacterial invasion has proven a promising strategy. Cellulose nanocrystals (CNCs), derived from bio-resources and functioning as nanoparticles (NPs), were modified with poly[2-(tert-butylamino) ethyl methacrylate] (PTA) through atom transfer radical polymerization (ATRP) to create CNCs-graft-PTA NPs (CNPs).

Preparation of 4-Allenyloxazolines from ()-2-En-4-yn-1-ol via Propargyl/Allenyl Isomerization.

A novel method for the preparation of 4-allenyl-oxazolines is described via the reaction of 2-en-4-yn-1-ols with trichloroacetonitrile in the presence of DBU. Reaction proceeds through the nucleophilic attack of OH functionality in to CClCN followed by cyclization, propargyl/allene isomerization, and protonation. In this investigation, it is noticed that propargyl/allene isomerization is sensitive to the substituents.

A Finite Element Model for Simulating Stress Responses of Permeable Road Pavement.

Permeable road pavements, due to their open-graded design, suffer from low structural strength, restricting their use in areas with light traffic volume and low bearing capacity. To expand application of permeable road pavements, accurate simulation of stress parameters used in pavement design is essential. A 3D finite element (3D FE) model was developed using ABAQUS/CAE 2021 to simulate pavement stress responses.

Recent Advances in Engineering Carriers for siRNA Delivery.

RNA interference (RNAi) technology has been a promising treatment strategy for combating intractable diseases. However, the applications of RNAi in clinical are hampered by extracellular and intracellular barriers. To overcome these barriers, various siRNA delivery systems have been developed in the past two decades.

[Application of metagenomic next-generation sequencing of bronchoalveolar lavage fluid in the diagnosis and treatment of refractory pneumonia in children].

Objectives: To investigate the clinical application of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) in the etiological diagnosis and treatment of refractory pneumonia (RTP) in children.

Methods: A retrospective analysis was performed on 160 children with RTP who were admitted to the Department of Pediatric Internal Medicine, Maternal and Child Health Hospital of Inner Mongolia Autonomous Region, from January 2020 to March 2023. According to whether mNGS was performed, they were divided into two groups: mNGS (=80) and traditional testing (=80).

A case report of Williams syndrome with main clinical manifestation of hypercalcemia and gastrointestinal bleeding as the main clinical manifestations, and with an accompanying literature review.

Background: Williams syndrome is an autosomal dominant multisystem disorder caused by a 1.5-1.8 Mb deletion on chromosome 7q11.

Changes to Material Phase and Morphology Due to High-Level Molybdenum Doping of ZnO Nanorods: Influence on Luminescence and Defects.

The influence of Mo on the electronic states and crystalline structure, as well as morphology, phase composition, luminescence, and defects in ZnO rods grown as free-standing nanoparticles, was studied using a variety of experimental techniques. Mo has almost no influence on the luminescence of the grown ZnO particles, whereas shallow donors are strongly affected in ZnO rods. Annealing in air causes exciton and defect-related bands to drop upon Mo doping level.

N6-Methyladenosine RNA Modification Landscape in the Occurrence and Recurrence of Nasopharyngeal Carcinoma.

Background: Nasopharyngeal carcinoma (NPC) is a type of squamous head and neck cancer with variable geographic distributions, with the highest incidence in Southeast Asia. Its primary treatment is radiotherapy due to its high radio sensitivity. However, the N6-methyladenosine (m6A) landscape in NPC, including recurrent NPC, has not been reported.

PBDB-T-Based Binary-OSCs Achieving over 15.83% Efficiency via End-Group Functionalization and Alkyl-Chain Engineering of Quinoxaline-Containing Non-Fullerene Acceptors.

Molecular backbone modification, alkyl-chain engineering, and end-group functionalization are promising strategies for developing efficient high-performance non-fullerene acceptors (NFAs). Herein, two new NFAs, named TPQ-eC7-4F and TPQ-eC7-4Cl, are designed and synthesized. Both molecules have linear octyl chains on fused quinoxaline-containing heterocyclics as the central backbone and difluorinated (2F)/dichlorinated (2Cl) 1,1-dicyanomethylene-3-indanone (IC) as the end-group units.

A Study on the Design Depth of Permeable Road Pavement through Dynamic Load Experiment.

This study investigated vertical strain and stress through a dynamic load experiment at the testing area of Ke-Da Road, Pingtung, Taiwan. A thirty-five-ton truck was moved at constant speeds of 40, 60, and 80 km/h to simulate heavy load conditions to study the mechanical variations. From the results, it was found that the strain and stress curves of the permeable road pavement showed asymmetry due to the viscoelastic property of the open-grade friction course.

How Does Entrepreneurial Team Relational Governance Promote Social Start-Ups' Organizational Resilience?

Why are some social entrepreneurial teams able to adapt to challenges and leverage the opportunities that are generated from a crisis, and why can some start-ups achieve sustained growth yet others do not? From the perspective of relational governance, this study unpacked the mechanism of how entrepreneurial teams promote social start-ups' abilities to deal with crises and the mediating role of team learning through a survey of 396 social entrepreneurial team members. The results showed four key findings. (1) Trust among entrepreneurial team members has a positive effect on organizational resilience, whereas shared vision and communication-cooperation do not.

Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study.

Background: Streptococcus pneumoniae (S. pneumoniae) is a major cause of bacterial meningitis, septicemia and pneumonia in children. Inappropriate choice of antibiotic can have important adverse consequences for both the individual and the community.

A Study on Heat Storage and Dissipation Efficiency at Permeable Road Pavements.

The main contributing factor of the urban heat island (UHI) effect is caused by daytime heating. Traditional pavements in cities aggravate the UHI effect due to their heat storage and volumetric heat capacity. In order to alleviate UHI, this study aims to understand the heating and dissipating process of different types of permeable road pavements.

Portable Interactive Pulse Tactile Recorder and Player System.

Pulse palpation is an effective method for diagnosing arterial diseases. However, most pulse measurement devices use preconfigured pressures to collect pulse signals, and most pulse tactile simulators can only display standard or predefined pulse waveforms. Here, a portable interactive human pulse measurement and reproduction system was developed that allows users to take arbitrary pulses and experience realistic simulated pulse tactile feedback in real time by using their natural pulse-taking behaviors.

miR-130a-Mediated KLF3 Can Inhibit the Growth of Lung Cancer Cells.

Background: The role of microRNA (miR) in tumors has been reported in numerous articles. Previous studies have found that miR-130a is low expressed in lung cancer, but the related mechanism has not been fully elucidated. This study mainly explores the mechanism of miR-130a in lung cancer, so as to provide potential therapeutic targets for clinical applications.

Evaluation of Serum 25-Hydroxyvitamin D and Bone Mineral Density in 268 Patients with Hip Fractures.

Objective: The aim of the present study was to evaluate the relationship among vitamin D nutritional status, bone mineral density, and other factors in elderly patients with brittle hip fractures.

Methods: The present study was a retrospective analysis of 268 patients, 102 men (38.06%) and 166 women (61.

Developing an Instrument for Assessing Self-Efficacy in Data Mining and Analysis.

With the continuous progress and penetration of automated data collection technology, enterprises and organizations are facing the problem of information overload. The demand for expertise in data mining and analysis is increasing. Self-efficacy is a pivotal construct that is significantly related to willingness and ability to perform a particular task.

Serum lipocalin-2 is a potential biomarker for the clinical diagnosis of nonalcoholic steatohepatitis.

Background/aims: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. We aimed to investigate the usefulness of a key biomarker, lipocalin-2 (LCN2), for the detection of NASH progression.

Methods: A mouse NASH model was established using a high-fat diet and a high-sugar drinking water.

Using high-dimensional features for high-accuracy pulse diagnosis.

Accurate pulse diagnosis is often based on extensive clinical experience. Recently, modern computer-aided pulse diagnostic methods have been developed to help doctors to quickly determine patients' physiological conditions. Most pulse diagnostic methods used low-dimensional feature vectors to classify pulse types.

Factors Influencing the Willingness of Universities' Business Management Departments to Implement Online Entrepreneurship Program and Its Effectiveness.

With the steady increase and popularization of innovations and applications on the Internet, more and more people are searching for and purchasing products online. The boom in e-commerce stimulates opportunities in online entrepreneurship. However, the risks and failure rate for online entrepreneurship are relatively high.

Analysis of circulating non-coding RNAs in a non-invasive and cost-effective manner.

Non-coding RNAs (ncRNAs) participate in regulation of gene expression, and are highly relevant to pathological development. They are found to be stably present in diverse body fluids, including those in the circulatory system, which can be sampled non-invasively for clinical tests. Thus, circulating ncRNAs have great potential to be disease biomarkers.

Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke.

Background And Aim: Stroke-associated pneumonia (SAP) is a common complication in patients with acute ischemic stroke (AIS). This study explored the potential relationship between serum vitamin D levels and SAP.

Methods: This study recruited 863 consecutive AIS patients.

Laser-cooling with an intermediate electronic state: Theoretical prediction on bismuth hydride.

The possibility of laser cooling of bismuth hydride (BiH) molecules has been investigated based on high-level ab initio calculations by considering the core-valence and the spin-orbit coupling (SOC) effects. The potential energy curves of the 12 Λ-S states as well as the 25 Ω states that split from them via SOC are obtained by multireference configuration interaction plus the Davidson correction. The properties of b-X transition are investigated.

A multiplex paper-based nanobiocatalytic system for simultaneous determination of glucose and uric acid in whole blood.

In this work, a versatile point-of-care assay platform based on a microfluidic paper-based analytic device (μPAD) was developed for the simultaneous detection of multiple targets. The μPAD with a central zone and six test zones is fabricated by a simple and inexpensive wax printing method. A flower-like hybrid nanocomplex synthesized with specific dual enzymes and Cu3(PO4)2 inorganic nanocrystals is spotted in the test zones on the μPAD, followed by the introduction of assay targets.