Publications by authors named "Yu-ling Wang"

Article Synopsis
  • Midazolam is a medication with hypnotic and sedative effects, important for various clinical uses, but its exact action on consciousness is not fully understood.
  • Research using advanced techniques like pharmacology and optogenetics has identified the locus coeruleus-ventrolateral preoptic nucleus noradrenergic neural circuit as key to how midazolam affects consciousness, particularly through α1 adrenergic receptors.
  • The study highlights the GABAA receptor as a critical site for midazolam's action, offering new insights that could improve understanding and management of consciousness recovery in medical settings.
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As a continuation of our research on the pesticide development of L., the chemical constituents of the seeds of were systematically investigated. Eleven natural compounds ( to ) were isolated from the EtOAc extract of .

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A subfamily of conserved proteins called serpins plays crucial roles in various physiological functions, particularly in the activation pathway of the serine protease cascade, an essential component of insect innate immunity. Here, we found Bombyx mori serpin 3 (BmSerpin3) was most highly expressed in the fat body, and was up-regulated after exposure to bacteria, fungus and virus. Further, the expression of BmSerpin3 in the hemocytes, fat body, midgut of silkworm larvae, and BmN cells was up-regulated upon Bombyx mori nucleopolyhedrovirus (BmNPV) infection.

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Article Synopsis
  • Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of mortality in epilepsy patients, with unclear underlying mechanisms that hinder effective prevention and treatment.
  • Current animal models used in SUDEP research have limitations due to differences between species, which affects their ability to accurately replicate the complex human condition.
  • The review proposes creating an ideal SUDEP model using brain-computer interfaces and artificial intelligence to enhance understanding of SUDEP's pathogenesis and advance prevention strategies.
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  • The study analyzed the characteristics of SARS-CoV-2 infections and reinfections in healthcare workers (HCWs) after vaccination and emergence of the Omicron variant between December 2022 and July 2023.
  • It found a reinfection rate of 26.1% among 760 HCWs, with symptoms during reinfection including high rates of fever, cough, and sore throat, and a median reinfection interval of 152 days.
  • The study concluded that while reinfections tend to have milder symptoms, there is still a significant reinfection rate, highlighting the need for improved infection prevention strategies within healthcare settings.
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Background And Objective: To compare the efficacy of EUS-guided celiac plexus neurolysis (CPN) and celiac plexus irradiation with iodine-125 (I) seeds with absolute ethanol for relieving pain in patients with advanced pancreatic cancer.

Methods: We retrospectively analyzed data of 81 patients with advanced pancreatic cancer who underwent EUS-CPN or EUS-I implantation between January 2017 and December 2020. Postoperative pain was assessed using visual analog scale (VAS) scores; self-assessments of quality of life and the median survival time were compared between the 2 groups.

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Article Synopsis
  • SARS-CoV-2 variants are emerging and challenging the immunity gained from previous infections and vaccinations, prompting a study on antibody responses over six months.* -
  • The research shows that most vaccinated or previously infected individuals develop antibodies against several variants, but there is significant immune evasion with newer strains like XBB.1.5, EG.5.1, and BA.2.86 compared to the original virus.* -
  • Around 57% of individuals in the study experienced re-infection, which boosted their antibody levels, suggesting that repeated exposure may enhance immunity against these evolving variants.*
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Separation of CH/CH mixtures is of significant importance in the chemical industry but remains a challenge due to the physicochemical similarities of CH and CH. Herein, a metal-organic framework (MOF), [Zn(μ-O)(PCTF)] (Zn-PCTF) (PCTF= 5-trifluoromethyl-1H-pyrazole-4-carboxylic), is provided for the removal of CH from CH/CH mixtures. Zn-PCTF displays a three-dimensional framework featuring one-dimensional pore channels with periodic bottleneck segments.

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The advent of general anesthesia (GA) has significant implications for clinical practice. However, the exact mechanisms underlying GA-induced transitions in consciousness remain elusive. Given some similarities between GA and sleep, the sleep-arousal neural nuclei and circuits involved in sleep-arousal, including the 5-HTergic system, could be implicated in GA.

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A highly efficient ratiometric electrochemiluminescence (ECL) immunoassay was explored by bidirectionally regulating the ECL intensity of two luminophors. The immunoassay was conducted in a split-type mode consisting of an ECL detection procedure and a sandwich immunoreaction. The ECL detection was executed using a dual-disk glassy carbon electrode modified with two potential-resolved luminophors (g-CN-Ag and Ru-MOF-Ag nanocomposites), and the sandwich immunoreaction using glucose oxidase (GOx)-modified SiO nanospheres as labels was carried out in a 96-well plate.

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As one of the interesting signaling mechanisms, the in situ growth reaction on a photoelectrode has proven its powerful potential in photoelectrochemical (PEC) bioanalysis. However, the specific interaction between the signaling species with the photoactive materials limits the general application of the signal mechanism. Herein, on the basis of an in situ growth reaction on a photoelectrode of single-atom-based photoactive material, a general PEC immunoassay was developed in a split-type mode consisting of the immunoreaction and PEC detection procedure.

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Three pargyline-phosphine copper(I) clusters, [Cu(CC-CHN)(PPh)](PF) (1) and [Cu(CC-CHN)(dppy)](X) (dppy = diphenyl-2-pyridylphosphine; X = PF for 2 and X = ClO for 3), were synthesized. Their structures were fully characterized using various spectroscopic methods and X-ray crystallography, which showed that the stoichiometry and nature of pargyline and phosphine ligands play an important role in tuning the structure and photophysical features of Cu(I) clusters. Interestingly, clusters 1, 2 and 3 exhibited red, orange and yellow phosphorescence with high quantum yields of 88.

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Adsorption separation of the Xe/Kr mixture remains a tough issue since Xe and Kr have an inert nature and similar sizes. Here we present a chlorinated metal-organic framework (MOF) [JXNU-19(Cl)] and its nonchlorinated analogue (JXNU-19) for Xe/Kr separation. The two isostructural MOFs constructed from the heptanuclear cobalt-hydroxyl clusters bridged by organic ligands are three-dimensional structures.

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Objective: To review the effectiveness of different physical therapies for acute and sub-acute low back pain supported by evidence, and create clinical recommendations and expert consensus for physiotherapists on clinical prescriptions.

Data Sources: A systematic search was conducted in PubMed and the Cochrane Library for studies published within the previous 15 years.

Review Methods: Systematic review and meta-analysis, randomized controlled trials assessing patients with acute and sub-acute low back pain were included.

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Getah virus (GETV) is a mosquito-transmitted disease that affects animals, causing fever, aseptic meningitis, and abortion. Its prevalence in China poses risks to both animal health and public well-being. Currently, there is a scarcity of seroepidemiological data on GETV due to the absence of commercial antibody detection kits for pigs.

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Herein, a metal-organic framework (MOF), {[(MeNH)][Cd(HO)][Cd(TrZ)(TPD)(DMF)]} (denoted as JXNU-18, TrZ = triazolate), constructed from the unique cucurbituril-shaped Cd(TrZ) secondary building units bridged by 2,5-thiophenedicarboxylic (TPD) ligands, is presented. The formation of the cucurbituril-shaped Cd(TrZ) unit is unprecedented, demonstrating the geometric compatibility of the organic linkers and the coordination configurations of the cadmium atoms. Each Cd(TrZ) unit is connected to eight neighboring Cd(TrZ) units through 30 TPD linkers, affording the three-dimensional structure of JXNU-18.

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Although ionic liquids (ILs) are of prime interest for the synthesis of various nanomaterials, they are scarcely utilized for the polyhydrido copper(I) [Cu(I)H] clusters. Herein, two air-stable Cu(I)H clusters, [CuH(dppy)](NTf) (CuH) and {CuH(dppy)[N(CN)]} (CuH), are synthesized in high yields for the first time from the ILs-driven conversion of an unprecedented cluster [CuH(dppy)](ClO) (CuH) by a facile three-layers diffusion crystal (TLDC) method, strategically introducing IL-NTf and IL-N(CN) as two types of unusual interfacial crystallized templates, respectively. Their structures are fully characterized by various spectroscopic methods and X-ray crystallography, which shows that the anion of IL plays an important role as an anion template and an anion ligand in controlling the structural conversion of Cu(I)H clusters.

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General anesthesia is widely used in various clinical practices due to its ability to cause loss of consciousness. However, the exact mechanism of anesthesia-induced unconsciousness remains unclear. It is generally thought that arousal-related brain nuclei are involved.

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Article Synopsis
  • The study focuses on how the locus coeruleus (LC) and noradrenergic transmission relate to sudden unexpected death in epilepsy (SUDEP).
  • It outlines a protocol to modulate the noradrenergic pathway from the LC to the heart to potentially prevent SUDEP in specific mouse models.
  • Key steps include creating SUDEP models, recording calcium signals, monitoring ECGs, and analyzing neurotransmitter components and neuron destruction.
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This study comprehensively assessed the effect of enhanced recovery after surgery (ERAS) on wound infection and postoperative complications in patients undergoing liver surgery. The PubMed, EMBASE, MEDLINE, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang electronic databases were searched to collect published studies on the use of ERAS in liver surgery until December 2022. Literature selection was performed independently by two investigators according to the inclusion and exclusion criteria, and quality evaluation and data extraction were performed.

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A pair of metal-organic frameworks (MOFs) of JXNU-15 (formulated as [Co(μ-OH)(BTB)(BPY)], BTB = benzene-1,3,5-tribenzoate and BPY = 4,4'-bipyridine) and its fluorinated JXNU-15(F) ([Co(μ-OH)(SFBTB)(BPY)]) based on the fluorous 1,3,5-tri(3,5-bifluoro-4-carboxyphenyl)benzene (SFBTB) ligands were presented. The detailed comparisons of the acetylene/carbon dioxide (CH/CO) separation abilities between the isostructural JXNU-15(F) and JXNU-15 were presented. In comparison with the parent JXNU-15, the higher CH uptake, larger adsorption selectivity of the CH/CO (50/50) mixture, and enhanced CH/CO separation performance endow JXNU-15(F) with highly efficient CH/CO separation performance, which is demonstrated by singe-component gas adsorptions and dynamic gas mixture breakthrough experiments.

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A closed bipolar electrochemiluminescence (BP-ECL) platform for sensitive prostate specific antigen (PSA) detection was proposed based on a novel synergistic signal amplification strategy. Specifically, glucose oxidase-loaded Cu-based metal-organic frameworks (Cu-MOFs/GOx) as bifunctional probes were bridged on the anodic interface with the target PSA as the intermediate unit. In virtue of the large loading capacity of Cu-MOFs, a large amount of a co-reactant, i.

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Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among epilepsy patients. However, the underlying mechanism remains elusive. Seizure-induced respiratory arrest (S-IRA) is recognized as a main cause of SUDEP, but the contribution of other factors such as cardiac arrhythmias cannot be excluded.

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The dorsal raphe nucleus (DR) and the pre-Bötzinger complex (PBC) may play an important role in regulating seizure-induced respiratory arrest (S-IRA), the main contributor to sudden unexpected death in epilepsy. Here, we describe pharmacological, optogenetic, and retrograde labeling approaches to specifically modulate the DR to PBC serotonergic pathway. We detail steps for implanting optical fibers and viral infusion into DR and PBC regions and optogenetic techniques for exploring the role of 5-hydroxytryptophan (5-HT) neural circuit of DR-PBC in S-IRA.

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