Publications by authors named "Yu-ki Iwasaki"

Background: Although catheter ablation techniques for atrial fibrillation (AF) have advanced, some cases of reconnections after pulmonary vein (PV) isolation still exist. The diversity of the anatomic wall thickness and fiber orientation around the PVs might contribute to reconnections.

Objective: The purpose of this study was to investigate the utility of the emphasis map's emphasize settings to determine optimal ablation sites.

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Article Synopsis
  • The Japanese Catheter Ablation (J-AB) registry, launched in August 2017, is a nationwide voluntary study led by the Japanese Heart Rhythm Society focused on collecting data about catheter ablation procedures.
  • In January 2022, the registry's data collection system shifted from REDCap to the Fountayn system to improve data management.
  • By the end of 2022, the registry compiled data from 90,042 procedures across 614 hospitals, highlighting the types of arrhythmias, outcomes, and complications, with participants averaging 66.7 years old and 65.9% being male.
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Atrial fibrillation (AF) is the most common cardiac arrhythmia observed in the elderly. Its prevalence rises with age, particularly in individuals over 80 years old. While catheter ablation has emerged as a first line therapy for the patients with symptomatic AF, evidence on its application in elderly patients remains controversial.

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Out-of-hospital cardiac arrest (OHCA) is a global public health problem, with survival rates remaining low at around 10% or less despite widespread cardiopulmonary resuscitation (CPR) training and availability of automated external defibrillators (AEDs). This is partly due to the challenges of knowing when and where a sudden OHCA occurs and where the nearest AED is located. In response, countries around the world have begun to use network technology-based smartphone applications.

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To improve clinical diagnoses, assessments of potential cardiac disease risk, and predictions of lethal arrhythmias, the analysis of electrocardiograms (ECGs) requires a more accurate method of weighting waveforms to efficiently detect abnormalities that appear as minute strains in the waveforms. In addition, the inverse problem of estimating the myocardial action potential from the ECG has been a longstanding challenge. To analyze the variance of the ECG waveforms and to estimate collective myocardial action potentials (APs) from the ECG, we designed a model equation incorporating the probability densities of Gaussian functions of time-series point processes in the cardiac cycle and dipoles of the collective APs in the myocardium.

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Article Synopsis
  • - The study analyzed the link between the number of guideline-directed medical therapy (GDMT) drugs and mortality in heart failure patients, involving 3,146 participants divided based on their prescribed medications at discharge.
  • - Findings showed that patients with 5 or more GDMT drugs and fewer than 4 non-GDMT (ni-GDMT) drugs had the lowest mortality rates, while those with less GDMT and more ni-GDMT drugs had the highest mortality rates over a three-year period.
  • - The results emphasized that the number of ni-GDMT drugs significantly impacted three-year mortality, suggesting that managing ni-GDMT is essential for improving outcomes in heart failure treatment, while the amount of GDMT alone did not worsen
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Background: Despite the positive impact of implantable cardioverter defibrillators (ICDs) and wearable cardioverter defibrillators (WCDs) on prognosis, their implantation is often withheld especially in Japanese heart failure patients with reduced left ventricular ejection fraction (HFrEF) who have not experienced ventricular tachycardia (VT) or ventricular fibrillation (VF) for uncertain reasons. Recent advancements in heart failure (HF) medications have significantly improved the prognosis for HFrEF. Given this context, a critical reassessment of the treatment and prognosis of ICDs and WCDs is essential, as it has the potential to reshape awareness and treatment strategies for these patients.

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Aims: Plasma volume status (PVS), a measure of plasma volume, has been evaluated as a prognostic marker for chronic heart failure. Although the prognostic value of PVS has been reported, its significance in patients with acute decompensated heart failure (ADHF) admitted to the cardiovascular intensive care unit (CICU) remains unclear. In this study, we examined the relationship between PVS and long-term mortality in patients with ADHF admitted to the CICU.

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Red blood cell (RBC) transfusion therapy is often performed in patients with acute heart failure (AHF) and anemia; however, its impact on subsequent cardiovascular events is unclear. We examined whether RBC transfusion influences major adverse cardiovascular events (MACE) after discharge in patients with AHF and anemia.We classified patients with AHF and anemia (nadir hemoglobin level < 10 g/dL) according to whether they received RBC transfusion during hospitalization.

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  • This study investigates the role of fractional excretion of urea nitrogen (FEUN) in identifying worsening renal function (WRF) and its relationship with outcomes in patients with acute heart failure (AHF).
  • Among 1,103 AHF patients, those with WRF had significantly higher rates of heart failure readmission, particularly when FEUN values were low or high.
  • The findings suggest that monitoring FEUN can help predict which AHF patients may have poor outcomes related to renal function, emphasizing its clinical importance in managing these patients.
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The Japanese Catheter Ablation (J-AB) registry, started in August 2017, is a voluntary, nationwide, multicenter, prospective, observational registry, performed by the Japanese Heart Rhythm Society (JHRS) in collaboration with the National Cerebral and Cardiovascular Center using a Research Electronic Data Capture system. The purpose of this registry is to collect the details of target arrhythmias, the ablation procedures, including the type of target arrhythmias, outcomes, and acute complications in the real-world settings. During the year of 2021, we have collected a total of 89 609 procedures (mean age of 66.

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Introduction: Although catheter ablation (CA) of tachycardia-bradycardia syndrome (TBS) in patients with atrial fibrillation (AF) is considered to be an effective treatment strategy, pacemaker implantations (PMIs) are often required even after a successful CA. This study aimed to elucidate the clinical predictors of a PMI after CA.

Methods: From 2011 to 2020, 103 consecutive patients diagnosed with TBS were retrospectively enrolled in the study.

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  • Ventricular tachycardia (VT) linked to primary cardiac tumors (PCTs) is rare in young patients but poses significant risks; this study investigates the mechanisms and treatments for PCT-VT.
  • Four patients with PCT-VT underwent surgery, showing drug-resistant VT due to a re-entry mechanism, with electroanatomical mapping indicating issues at the tumor-myocardium interface.
  • Histopathological analysis revealed tumor infiltration causing myocardial disarray, and for patients with unresectable tumors, using cryoablation was effective in controlling VT.
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Introduction: Cardiac resynchronization therapy (CRT) is well-established for treating symptomatic heart failure with electrical dyssynchrony. The left ventricular (LV) lead position is recommended at LV posterolateral to lateral sites in patients with left bundle branch block; however, its preferred region remains unclear in patients being upgraded from right ventricular (RV) apical pacing to CRT. This study aimed to identify the preferred LV lead position for upgrading conventional RV apical pacing to CRT.

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  • The study explores the use of fractional excretion of urea nitrogen (FEUN) as a marker for assessing volume status in heart failure patients with chronic kidney disease.
  • It analyzes 516 patients and finds that those with medium FEUN values have lower rates of heart failure readmission compared to those with low, high, or extremely high FEUN values.
  • The results suggest that FEUN could help in risk stratification for post-discharge readmissions in these patients, indicating the need for careful volume management.
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Introduction: Data are lacking on the extent to which patients with non-valvular atrial fibrillation (AF) who are aged ≥80 years benefit from ablation treatment. The question pertains especially to patients' postablation quality of life (QoL) and long-term clinical outcomes.

Methods And Analysis: We are initiating a prospective, registry-based, multicentre observational study that will include patients aged ≥80 years with non-valvular AF who choose to undergo treatment by catheter ablation and, for comparison, such patients who do not choose to undergo ablation (either according to their physician's advice or their own preference).

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The Kumamoto criteria have been proposed as a non-invasive screen for transthyretin amyloid cardiomyopathy. This study assessed the validity of the Kumamoto criteria externally. The study included 138 patients (median age 73 years; 65% male) who underwent Tc-pyrophosphate (PYP) scintigraphy.

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Obstructive sleep apnea (OSA) is a highly prevalent disorder in patients with atrial fibrillation (AF). Although there has been an increase in the incidence of AF due to the aging population, it has been reported that OSA is still underdiagnosed because many patients remain asymptomatic or unaware of the symptoms associated with OSA, such as daytime sleepiness. Untreated OSA reduces the effectiveness of AF treatment, regardless of pharmacological or non-pharmacological modes of therapy, such as catheter ablation.

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