Publications by authors named "Yu-jiao Jia"
[Detection of heterogeneity and evolution of subclones in t(8;21) AML by QM-FISH].
Zhonghua Xue Ye Xue Za Zhi
October 2013
Article Synopsis
- - The study investigates the various subclones present in acute myeloid leukemia (AML) characterized by the genetic abnormality t(8;21), using a detailed method called quantitative multicolor-fluorescence in situ hybridization (QM-FISH) to track genetic variations and evolutionary relationships among them.
- - Researchers examined 36 AML cases along with one relapsed case, identifying multiple genetic alterations including additional signals for genes such as AML1, ETO, and WT1, revealing crucial information about how these subclones differ and evolve over time.
- - Results showed that a significant portion of the cases displayed genetic abnormalities, particularly indicating that male patients often experienced deletion of the AML1 signal, suggesting a potential link between these
[Effects of transcription factor GATA-2 on transcriptive regulation of iASPP gene].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2013
iASPP can prompt the cell proliferation and inhibit the apoptosis of many cells. There are putative binding sites of transcription factor GATA-2 upstream of iASPP transcription start site. GATA-2 plays an important role in the proliferation and differentiation of hematopoietic stem cells (HSC) and progenitors.
View Article and Find Full Text PDF[Study on expression of PTEN gene and its pseudogene PTENP1 in acute leukemia and correlation between them].
Zhonghua Xue Ye Xue Za Zhi
November 2012
Article Synopsis
- This study aimed to examine how the expression of PTEN and its pseudogene PTENP1 correlates in acute leukemia patients and to see if PTENP1 affects PTEN expression in leukemia cells.
- The researchers analyzed bone marrow samples from 138 newly diagnosed acute leukemia patients and 15 healthy controls using various molecular techniques to measure mRNA and protein levels.
- Results showed significantly lower levels of PTEN and PTENP1 in leukemic cells compared to healthy controls, and while PTENP1 positively impacted PTEN mRNA levels in a cell line model, it did not significantly change PTEN protein levels or cell growth.
[Effect of metformin on acute promyelocytic leukemia cell line NB4 and its mechanism].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2012
The purpose of this study was to investigate the effect and molecular mechanism of metformin (Met) on biological characteristics of acute promyelocytic leukemia (APL) cell line NB4. NB4 cells were treated with various concentrations of Met for different time, MTT method was used to detect cell proliferation, the alteration of cell apoptosis was analyzed by flow cytometry, and the change of cell adhesion ability was examined by cell adhesion assay. NB4 cells were pretreated with U0126, a specific inhibitor for extracellular signal-regulated kinase (ERK) phosphorylation, ERK phosphorylation was assessed by Western blot analysis, apoptosis and cell adhesion ability were evaluated by flow cytometry and cell adhesion test respectively.
View Article and Find Full Text PDFAlternaria alternata has received considerable attention in current literature and most of the studies are focused on its pathogenic effects on plant chloroplasts, but little is known about the characteristics of programmed cell death (PCD) induced by metabolic products (MP) of A. alternata, the effects of the MP on mitochondrial respiration and its relation to PCD. The purpose of this study was to explore the mechanism of MP-induced PCD in non-green tobacco BY-2 cells and to explore the role of mitochondrial inhibitory processes in the PCD of tobacco BY-2 cells.
View Article and Find Full Text PDFThe purpose of this study was to explore the mechanisms by which Alternaria alternata damages tobacco (Nicotiana tabacum) leaves. Treatment with A. alternata metabolic products enhanced senescence in leaves of different ages, as indicated by the significant decrease in chlorophyll, soluble protein, photosynthetic O(2) evolution and catalase (CAT, EC 1.
View Article and Find Full Text PDF