Serum urate is associated with an increased risk of inflammatory bowel disease: A bidirectional Mendelian randomization study.

Background: Previous studies have indicated bidirectional associations between urate levels and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD). However, it remains unclear whether the observations are causal because of confounding factors.

Aim: To investigate the causal associations between urate levels and IBD using bidirectional Mendelian randomization (MR).

Regulation of Carbohydrate Metabolism by Trehalose-6-Phosphate Synthase 3 in the Brown Planthopper, .

(Stål) (Hemiptera: Delphacidae) is one of the pests that harm rice. In this paper, a new trehalose-6-phosphate synthase gene, , was identified by transcriptome sequencing and gene cloning. To explore its role in the energy metabolism of we examined the carbohydrate contents at different stages of development, the tissue expression of , and some physiological and biochemical indicators by injecting dsTPS3 and dsTPSs (a proportional mixture of dsTPS1, dsTPS2, and dsTPS3).

Hafnium-Doped Mesoporous Silica as Efficient Lewis Acidic Catalyst for Friedel-Crafts Alkylation Reactions.

The development of an efficient solid catalyst for Friedel-Crafts (FC) reactions is of great importance to organic synthetic chemistry. Herein, we reported the hafnium-doped mesoporous silica catalyst Hf/SBA-15 and its first use for Friedel-Crafts alkylation reactions. Catalysts with different Si/Hf ratios were prepared and characterized, among which Hf/SBA-15(20) (Si/Hf = 20:1) was the most active catalyst, offering up to 99.

Patient-specific three-dimensional printed heart models benefit preoperative planning for complex congenital heart disease.

Background: Preoperative planning for children with congenital heart diseases remains crucial and challenging. This study aimed to investigate the roles of three-dimensional printed patient-specific heart models in the presurgical planning for complex congenital heart disease.

Methods: From May 2017 to January 2018, 15 children diagnosed with complex congenital heart disease were included in this study.

Plasma levels of alarmin HNPs 1-3 associate with lung dysfunction after cardiac surgery in children.

Background: Early onset of lung injury is considerable common after cardiac surgery and is associated with increasing in morbidity and mortality, but current clinical predictors for the occurrence of this complication always have limited positive warning value. This study aimed to evaluate whether elevated plasma levels of human neutrophil peptides (HNPs) 1-3 herald impaired lung function in infants and young children after cardiac surgery necessitating cardiopulmonary bypass (CPB).

Methods: Consecutive children younger than 3 years old who underwent cardiac surgery were prospectively enrolled.

dl-3-n-butylphthalide promotes neuroplasticity and motor recovery in stroke rats.

Backgrounds And Aims: Racemic l-3-n-butylphthalide (dl-NBP), is able to achieve a functional recovery in animal models of cerebral ischemia, vascular dementia, and Alzheimer's disease. In this study, we investigated the effect of dl-NBP on axonal growth, neurogenesis and behavioral performances in rats with cerebral ischemia.

Methods: Focal cerebral ischemia in rats was produced by intracerebral injection of endothelin-1.

[Progress on Hypoxic-ischemic Brain Damage Associated with CCR2 and CCL2].

Hypoxic-ischemic brain damage (HIBD) is referred to a common type of cerebral damage, which is caused by injury, leading to shallow bleeding in the cortex with intact cerebral pia mater. In recent years, studies show that a various kinds of immune cells and immune cellular factors are involved in the occurrence of HIBD. CC chemokine receptor 2 (CCR2) is a representative of CC chemokine receptor, and is widely distributed in cerebral neuron, astrocyte, and microglial cells, and is the main chemo-tactic factor receptor in brain tissue.