Low-frequency repetitive transcranial magnetic stimulation to the right Broca mirror area for improving auditory comprehension in a sensory aphasia after stroke: a case report.

Aphasia is a common consequence of stroke and repetitive transcranial magnetic stimulation (rTMS) may be a promising brain stimulation technique in the treatment of aphasia. However, there are few reports about the therapeutic effect of rTMS for Broca's area in patients with sensory aphasia. This study reported one stroke patient with sensory aphasia who received 6 treatment sessions of low-frequency rTMS before speech and language therapy.

Correlation between focal lesion sites and language deficits in the acute phase of post-stroke aphasia.

Introduction: Focal lesion sites can predict the language function of patients with aphasia during the subacute or chronic phases. However, the relationship between focal lesion sites and language deficits in the acute phase remains unclear. Therefore, our study aimed to investigate the relationship between focal lesion sites and fluency, auditory comprehension, repetition and naming deficits in patients with acute aphasia to further understand the pathophysiological mechanism of aphasia.

Toxicological evaluation of the red mold rice extract, ANKASCIN 568-R: 13-week chronic toxicity, and genotoxicity studies.

ANKASCIN 568-R is an extract derived from red mold rice (RMR) fermented using NTU 568. RMR fermented using NTU 568 prevents cardiovascular diseases and decreases blood lipid levels. This study evaluates the safety of ANKASCIN 568-R, since it has not determined yet.

[Improvement of Medical Alarm Management Accuracy for Critical Care Nurses in a Continuous Renal Replacement Therapy Unit].

Background: Continuous renal replacement therapy (CRRT) is a common medical treatment for critically ill patients. The alarm management component of CRRT is urgent and time sensitive. Patient safety and survival rates are jeopardized if critical care nurses do not handle this situation properly.

Preliminary validation study of the WHO quality of life (WHOQOL) scales for people with spinal cord injury in Mainland China.

Objective: To validate the WHOQOL Scales (WHOQOL-BREF and WHOQOL-DIS module) for people with spinal cord injury in Mainland China.

Design: Cross-sectional study.

Setting: Shanghai Sunshine Rehabilitation Center.

Meta-Analysis on the Efficacy and Safety of Laparoscopic Surgery for Large Gastric Gastrointestinal Stromal Tumors.

Background: The aim of this study was to conduct a meta-analysis comparing the safety and feasibility of laparoscopic versus open resection for gastric gastrointestinal stromal tumors (GISTs) larger than 5 cm.

Method: We searched the Cochrane Library, PubMed, and Embase for relevant articles. Randomized and nonrandomized clinical trials were identified and included in this study.

Fish assemblage changes over half a century in the Yellow River, China.

Riverine environments have been threatened by anthropogenic perturbations worldwide, whereby their fish assemblages have been modified by habitat changes and nonendemic species invasions. We assessed changes in fish assemblages by comparing the species presence in historical and contemporary fish data in the Yellow River from 1965 to 2015. The temporal change in species assemblages was found with increased nonendemic species and fewer natives.

Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil.

Objective: To investigate the predictors of hypophosphatemic osteomalacia induced by adefovir dipivoxil (ADV) and to monitor for early detection.

Patients And Methods: Hospitalized patients who were diagnosed with ADV-related hypo-phosphatemic osteomalacia were recruited and retrospectively analyzed in our hospital from January 2012 to December 2016. A telephone interview was conducted at 1, 3, 6, 9, 12, and 24 months after cessation of ADV.

Daily expression of two circadian clock genes in compound eyes of Helicoverpa armigera: evidence for peripheral tissue circadian timing.

Circadian clock genes in peripheral tissues usually play an important role in regulating the circadian rhythms. Light is the most important environmental signal for synchronizing endogenous rhythms with the daily light-dark cycle, and compound eyes are known as the principal circadian photoreceptor for photic entrainment in most moths. However, there is little evidence for circadian timing in compound eyes.

miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3.

MicroRNAs (miRNAs) function as essential post-transcriptional modulators of gene expression involved in a wide range of physiologic and pathologic states, including cancer. Numerous miRNAs have been deregulated in hepatocellular carcinoma (HCC). Here, we investigated the role of miR-141 in HCC.

Ultrasound assessment of injury to the posterior ligamentous complex in patients with mild thoracolumbar fractures.

Objective: To assess the value of ultrasonographic imaging of the posterior ligamentous complex (PLC) to diagnose ligamentous injuries, in patients with mild thoracolumbar fractures.

Methods: Patients with thoracolumbar fractures were included in this prospective study. Patients underwent palpation of the midline of the back, and ultrasonography was performed over the entire thoracolumbar region by an experienced sonographer.

Adding vancomycin to bone cement: research on its influence on mechanical and fixation strength using rabbit femoral prostheses.

Objective: To compare the influence of different methods of adding vancomycin on the strength of bone cement used for fixing rabbits' femoral prostheses.

Methods: Eighteen New Zealand white rabbits (36 femora) were allocated to three groups of six rabbits (12 femora) each: a control group, an experimental group 1 and experimental group 2. The bone cement used in the control group was mixed manually without vancomycin; in experimental group 1 it was mixed manually with 5% (2 g/40 g) vancomycin; and in experimental group 2 it was mixed in a vacuum with 5% (2 g/40 g) vancomycin.

[Polymorphism of SNPs in the lipoprotein lipase (LPL) in Siniperca chuatsi and their association with feed habit domestication].

Sinperca chuatsi usually refuses eating dead bait or man-made feed due to its specific feeding habit. It was showed that some S. chuatsi could be induced to take lifeless bait with domestication gradually after long-term of cultivation.

Age-related changes in the atrial muscarinic type 2 receptor and their effects on atrial fibrillation vulnerability in rabbits.

Aging plays an important role in increased vulnerability to atrial fibrillation (AF). Mediated by activity at the muscarinic type 2 receptor (M2R), the parasympathetic nerve contributes to the onset of AF. The purpose of this study was to investigate whether aging changes the distribution of M2R in the atrial myocardium and to determine the impact of these changes on AF vulnerability.

Superior vena cava Doppler flow changes in rabbits with acute thromboembolic pulmonary hypertension.

Objective: The purpose of this study was to explore the superior vena cava (SVC) Doppler flow changes in rabbits with acute thromboembolic pulmonary hypertension (ATEPAH) and its value in evaluating pulmonary pressure.

Methods: The systolic peak flow velocity (SPV), ventricular reverse peak flow velocity (VrPV), diastolic peak flow velocity (DPV), and atrial reverse peak flow velocity (ArPV) of the SVC were measured on end expiration with pulsed wave Doppler echocardiography in 30 rabbits with different degrees of ATEPAH. Linear regression and the Bland-Altman method were used to analyze the correlation of Doppler flow velocities of the SVC to the catheter-measured pulmonary arterial systolic pressure (PASP).

A rabbit model with acute thrombo-embolic pulmonary hypertension created with echocardiography guidance.

A rabbit model of acute thrombo-embolic pulmonary hypertension was developed by infusing self-thrombi into the right femoral vein and simultaneously measuring the pulmonary artery pressure via a right heart catheter and echocardiography. The model was used to explore the usefulness of an ultrasound-guided protocol. In the present study, acute thrombo-embolic pulmonary hypertension was produced in 25 of 30 healthy New Zealand rabbits; the success rate was 83%.

Cytoglobin up-regulated by hydrogen peroxide plays a protective role in oxidative stress.

Cytoglobin (Cygb) is a recently discovered intracellular respiratory globin, which exists in all types of cells. It has been suggested that Cygb has a role in protecting cells against oxidative stress. In the present study we have tested this hypothesis.

Alpha 2,6-sialyltransferase I expression in the placenta of patients with preeclampsia.

Background: The expression of sialyl-glycoconjugates changes during development, differentiation and oncogenic transformation, tumor invasion and metastasis. Similarly, in the early stage of pregnancy, trophoblast cells have to undergo adhesion, invasion, and proliferation to develop a healthy placenta; the cytobiologic behavior is similar to tumor growth and invasion. Inadequate trophoblast invasion to the spiral artery in the 2nd trimester of pregnancy was believed to be correlated with pregnancy complications, including preeclampsia.

Altered mRNA expressions of sialyltransferases in ovarian cancers.

Objective: Aberrant glycosylation occurs in essentially all types of experimental and human cancers, and many glycosyl epitopes constitute tumor-associated antigens (for example, CA125). Many recent studies have indicated that some, if not all, aberrant glycosylation is a result of altered sialyltransferase (ST) expression; however, there is little known of the role of the altered mRNA expression of ST in ovarian cancers.

Methods: Alterations in ST mRNA expression in postmenopausal ovarian tissues, including those of normal controls (n=24) and malignant serous ovarian cancers (n=24), were examined by means of real-time quantitative reverse transcription-polymerase chain reaction (RTQ-PCR).

Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway.

Background: Mechanical stress induces many pathophysiological effects in cardiomyocytes. The objective of this study was to test the hypothesis that angiotensin II is a potential mediator of stretch-induced activation of matrix metalloproteinases (MMP).

Methods: Neonatal rat cardiomyocytes grown on a flexible membrane were cyclically stretched achieving up to 20% elongation at 60 cycles/min (using a vacuum).

Amphetamine activates connexin43 gene expression in cultured neonatal rat cardiomyocytes through JNK and AP-1 pathway.

Objective: Amphetamine has been known to induce cardiac dysrhythmia and sudden death. However, the molecular mechanism for the induction of dysrhythmia is not known. Connexin43 (Cx43) plays an important role for arrhythmogenesis.

[Scanning electronic microscope observation of elastic fiber of anastomosed artery].

Objective: To observe the architecture of elastic fiber of anastomosed artery.

Methods: The right femoral arteries of 60 Wistar rats were cut off transversely and end-to-end anastomosis were performed. On the 3rd, 7th, 14th, 21st, 30th and 90th days after operation, the anastomosed artery segments were harvested and fixed by 10% formalin.