Publications by authors named "Yu-huan Jiang"
The Value of Common Laboratory Markers in Predicting the Severity of COVID-19 Patients.
Infect Drug Resist
November 2024
Purpose: The aim of the present study was to identify more effective laboratory markers to assess the severity of corona virus disease 2019 and predict the progression of the disease by collecting more laboratory markers and variables.
Patients And Methods: In this study, most risk factors, including epidemiological characteristics, blood cell counts, cytokines, and infection markers, were collected from 126 patients with COVID-19 to assess their predictive value.
Results: The area under curve (AUC) of Albumin (Alb) to fibrinogen (Fib) ratio (AFR) (0.
Rituximab-induced gut microbiota changes in Chinese neuromyelitis optica spectrum disorders.
Mult Scler Relat Disord
June 2024
Background: Recent evidence shows that immunosuppressive agents can affect the gut microbiota in autoimmune diseases. However, the relationship between the gut microbiome and B-cell depletion immunotherapy in neuromyelitis optica spectrum disorder (NMOSD) remains poorly understood.
Objectives: To evaluate the distinct intestinal microbial patterns and serum cytokine levels after short-term rituximab treatment (three months) in patients with NMOSD.
Extracellular vesicles isolation from urine was severely interfered by polymeric Tamm-Harsefall protein due to its ability to entrap exosome. Studies had been reported to optimize the extraction of urine extracellular vesicles by using reducing agents, surfactants, salt precipitation or ultrafiltration, but rarely based on highly specific purification methods. We optimized the density gradient centrifugation method for the isolation of urinary small extracellular vesicles (sEV) and compared seven differential centrifugation protocols to obtain the high-yield and high-purity sEV isolation procedures.
View Article and Find Full Text PDFBackground: Monoclonal antibodies of anti-epidermal growth factor receptor (EGFR) have been recommended as first-line therapy for patients with left-sided metastatic colorectal cancer (mCRC) with wild-type . The effect of tumour laterality on antivascular endothelial growth factor antibody and how to optimise targeted therapies for the right-sided cases remain controversial.
Patients And Methods: A comprehensive meta-analysis enrolling 16 first-line clinical trials was performed to evaluate the efficacy of chemotherapy alone and chemotherapy plus targeted therapies for patients with mCRC with right primary tumour site, and we validated the results in metastatic setting (14 trials containing 4306 patients with unresectable mCRC).
K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711.
Biochem Biophys Res Commun
January 2020
Article Synopsis
- * This study shows that exosomes from K562 leukemia cells carry microRNA miR-711, which negatively impacts the adhesion of BM-MSCs.
- * Specifically, miR-711 decreases the expression of the adhesion molecule CD44 in BM-MSCs, leading to reduced adhesion capabilities when exposed to K562-derived exosomes.
Article Synopsis
- The study investigates how factors like chronic inflammation, tumor location (right vs. left-sided), and certain blood markers (FPR, AFR) affect the survival of patients with metastatic colorectal cancer (mCRC).* -
- Elevated FPR and low AFR were linked to worse survival, especially in right-sided mCRC, and FPR was a strong predictor of poor outcomes across different patient groups.* -
- The research suggests that FPR can help tailor treatments, as patients with high FPR may respond better to specific therapies like bevacizumab with radiochemotherapy.*
Article Synopsis
- Chronic inflammation is linked to the development of esophageal squamous cell carcinoma (ESCC), leading researchers to explore the prognostic significance of various blood ratio markers in patients who underwent surgery.
- A study involving 153 ESCC patients analyzed preoperative levels of albumin, fibrinogen, and different blood cell ratios to evaluate their effects on overall survival after three years.
- Results showed that high levels of fibrinogen, dNLR, and PLR, along with low albumin and AFR, correlated with decreased survival rates; notably, a higher ADS score indicated a significantly shorter overall survival for patients.
Aim: To investigate prognostic value of preoperative inflammatory biomarkers in hepatocellular carcinoma (HCC).
Patients & Methods: Preoperative circulating fibrinogen, prealbumin, fibrinogen to prealbumin ratio (FPR), neutrophil to lymphocyte ratio, derived neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, platelet to lymphocyte ratio were detected and calculated in 230 HCC patients. X-tile software, Kaplan-Meier curve, Cox regression, time-dependent receiver-operating characteristic were used to explored prognostic roles of them in HCC.
Article Synopsis
- The study investigates how certain blood markers related to inflammation and nutrition, like albumin-to-fibrinogen ratio and fibrinogen levels, can predict survival in colorectal cancer (CRC) patients.
- Data was analyzed from 702 patients over three years, using various methods to assess the prognostic value of these markers and develop a nomogram for predicting outcomes.
- Results showed that a high fibrinogen-to-pre-albumin ratio (FPR) suggested poorer survival, while the novel carcinoembryonic antigen (CEA)-carbohydrate antigen 19-9 (CA199)-FPR score (CCF) was found to be a more effective predictor for determining which patients might benefit from chemotherapy.
Background: Inflammation and nutrition are closely associated with initiation and progression of colorectal cancer (CRC). This study aimed to investigate the diagnostic value of the FAR (FAR = 100*Fibrinogen/Albumin) and FPR (FPR = Fibrinogen/pre-Albumin) in CRC.
Methods: Neutrophil-to-lymphocyte ratio (NLR), FPR, and FAR were calculated in 455 newly diagnosed CRC patients, 455 healthy individuals, and 455 benign controls with colorectal polyp.
Article Synopsis
- Chronic inflammation plays a significant role in the development and spread of lung cancer (LC), and this study focused on assessing the prognostic value of the albumin-to-fibrinogen ratio (AFR), fibrinogen (Fib), and albumin (Alb) in LC patients.
- An analysis of 412 LC patients revealed that high Fib and low AFR and Alb levels correlated with a higher risk of mortality, especially in non-small cell lung cancer (NSCLC) patients across all stages.
- Additionally, patients with high AFR who received chemo-radiotherapy had better clinical outcomes compared to those with low AFR, indicating that AFR could be a promising biomarker for predicting the success of treatment in NSCLC patients.
Article Synopsis
- * Researchers discovered that exosomes (tiny particles released by cells) from imatinib-resistant CML cells can be taken up by sensitive CML cells, imparting drug resistance through the transfer of miR-365, a specific microRNA.
- * The study shows that when sensitive CML cells receive miR-365 from resistant cells, they become less responsive to the drug and more likely to survive (i.e., less apoptosis), highlighting the role of exosomes in spreading drug resistance in CML.
Article Synopsis
- - Pleural effusion (PE) is a complication from various diseases like lung cancer and tuberculosis, but there's no effective way to determine its cause clinically.
- - The study identified and compared exosomal microRNAs (miRNAs) in PE cases related to lung adenocarcinoma, tuberculosis, and benign conditions using deep sequencing and qRT-PCR techniques.
- - A total of 171 miRNAs were found to differ among the PE types, with 11 showing significant differences, suggesting that specific miRNA profiles could serve as potential biomarkers for diagnosing the cause of PE in future studies.
Article Synopsis
- This study investigates the role of inflammatory biomarkers, particularly the fibrinogen/pre-Albumin ratio (FPR), in predicting the prognosis of gastric cancer (GC) patients undergoing surgery.
- A total of 360 patients with stage II and III GC were analyzed to determine correlations between various biomarkers and overall survival (OS).
- The results revealed that lower levels of albumin and higher FPR were linked to shorter OS, with FPR being identified as a significant prognostic factor, especially for stage III patients receiving chemotherapy.
With the method of fluorescence polarization (FP), we screened small molecule inhibitors for PLK1 PBD to identify the lead compounds for antitumor drugs. FP led to the identification of a potent hit, F083-0063, whose inhibition rate was (99.7 ± 0.
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