Clinical Significance and Potential Role of Overexpression in Hepatocellular Carcinoma: An Integrated Analysis Based on Multiple Databases.

Hepatocellular carcinoma (HCC) is a solid tumor with high recurrence rate and high mortality. It is crucial to discover available biomarkers to achieve early diagnosis and improve the prognosis. The effect of in HCC still remains unrevealed.

Ischemic postconditioning exerts neuroprotective effect through negatively regulating PI3K/Akt2 signaling pathway by microRNA-124.

Ischemic stroke is a serious threat to human life and health, which is often accompanied by cerebral ischemia-reperfusion (I/R) injury in clinic. Ischemic postconditioning (IPostC) is a short period of mild non-fatal ischemia in the early stage of cerebral I/R injury. However, there are few reports about the protective effect of IPostC.

Theoretical Study on the Aggregation of Copper Clusters on a Liquid Surface.

The ground state structures of copper clusters with different sizes along with their aggregation have been systematic investigated using Amsterdam Density Functional (ADF) and Atomistix ToolKit (ATK) programs. On the basis of geometry optimization, some Cu clusters with more stable structures which were not reported previously have been revealed. In most cases, these Cu clusters prefer to adopt icosahedral structures which originate from the 13-atom icosahedron.

Correlation of LARP1 and E-cadherin expression with prognosis of intrahepatic cholangiocarcinoma.

Objective: The abnormal expression of LARP1 and E-cadherin (E-cad) is related to tumor occurrence and metastasis. Our study analyzed the expression of LARP1 and E-cad in intrahepatic cholangiocarcinoma (ICC) and investigated the prognostic value of the two proteins.

Methods: Immunohistochemistry was performed to detect the expression of LARP1 and E-cad in 50 ICC clinical specimens with adjacent normal tissues and 20 normal bile duct tissues.

Health correlates, addictive behaviors, and peer victimization among adolescents in China.

Background: Peer victimization has been recognized as a common social problem affecting children and adolescents in all parts of the world. This study aims to examine the prevalence of different types of peer victimization and to evaluate the associations between peer victimization and health correlates.

Methods: Using a large population sample of 18,341 adolescents aged 15-17 years from 6 cities in China, this study estimated the prevalence of different types of peer victimization, addictive behaviors, and health-related variables with self-administrated questionnaires.

Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression.

Ischemic preconditioning and ischemic postconditioning (IPostC) represent promising strategies to reduce ischemia-reperfusion (I/R) injury and attenuate the lethal ischemic damage following stroke. However, the mechanism underlying this attenuation remains to be elucidated. It was hypothesized that alterations in microRNA (miRNA) expression in the cerebral cortex and hippocampus of mice following I/R is associated with the functional improvement induced by IPostC.

Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues.

There are two forms of brain-derived neurotrophic factor (BDNF), precursor of BDNF (proBDNF) and mature BDNF, which each exert opposing effects through two different transmembrane receptor signaling systems, consisting of p75 neurotrophin receptor (p75NTR) and tyrosine receptor kinase B (TrkB). Previous studies have demonstrated that proBDNF promotes cell death and inhibits the growth and migration of C6 glioma cells through p75NTR , while mature BDNF has opposite effects on C6 glioma cells. It is hypothesized that mature BDNF is essential in the development of malignancy in gliomas.

Spontaneous running wheel improves cognitive functions of mouse associated with miRNA expressional alteration in hippocampus following traumatic brain injury.

Traumatic brain injury (TBI) is an insult to the brain that results in impairments of cognitive and physical functioning. Both of human research and animal studies demonstrate that spontaneous exercise can facilitate neuronal plasticity and improve cognitive function in normal or TBI rodent models. However, the possible mechanisms underlying are still not well known.

Mature BDNF promotes the growth of glioma cells in vitro.

High-grade glioma is incurable and is associated with a short survival time and a poor prognosis. There are two forms of brain-derived neurotrophic factor (BDNF), proBDNF and mature BDNF, which exert opposite effects. Their diverse actions are mediated through two different transmembrane receptor signalling systems: p75NTR and TrkB.

ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro.

Background: High-grade glioma is incurable, with a short survival time and poor prognosis. The increased expression of p75 neurotrophin receptor (NTR) is a characteristic of high-grade glioma, but the potential significance of increased p75NTR in this tumor is not fully understood. Since p75NTR is the receptor for the precursor of brain-derived neurotrophic factor (proBDNF), it is suggested that proBDNF may have an impact on glioma.

[Expression of programmed cell death 5 and apoptosis during atrophy of the parotid gland cells].

Objective: To investigate the expression and relationship of programmed cell death 5 (PDCD5) and cell apoptosis in the parotid gland after leading duct ligation in rat and elucidate the role of PDCD5 on the atophy of parotid gland.

Methods: The Wistar rat model of leading duct ligation was established, and the samples of parotid gland were obtained from different time point (0, 1, 3, 5, 7, 14, 21, 30, 60, 90 and 120 d). The expression of PDCD5 protein was examined by immunohistochemistry.

[Wavelength calibration research on the automatic grating monochromator for orthogonal Czerny-Turner structure].

The wavelength calibration research on the automatic grating monochromator for orthogonal Czerny-Turner structure was investigated. Combined with the structure parameters and characteristic of this monochromator, the sinusoid that accords with the grating equation was proposed as the function of the wavelength calibration. Based on the principle of the least square method, the formula of the fitting residual error of the wavelength calibration was given.

[Optical system design of plane grating double monochromator].

The plane grating double monochromator is the important part of the instrument for testing diffraction efficiency of plane grating, and in order to accomplish the research of the instrument, the optical system design and simulation of the plane grating double monochromator was investigated. The instrument mainly consists of light source, front monochromator, testing monochromator and detector, and combined with the practical requirement, the corresponding light source, detector and the structure of the optical path were selected. According to the design requirement, the design and simulation of the optical system of the front monochromator and testing monochromator were done respectively, and the spot diagram of the image surface and the results of real ray trace were given.

[Studies on the chemical constituents from the flowers of Ophiopogon japonicus].

Objective: To study the chemical constituents from the flowers of Ophiopogon japonicus.

Methods: Column chromatography and spectral analysis were used to isolate and identify the constituents.

Results: Eleven compounds were obtained and identified as beta-sitosterol (I), diosgenin (II), daucosterol (III), ophiopogonin C' (IV), dioscin (V), 7-dihy-droxy-6-methyl-3-(4'-hydroxybenzyl) chroman-4-one(VI), luteolin (VII), kaempferol-3-O-beta-D-glucopyranosides (VIII), kaempferol-3-O-(6"-tigloyl) -beta-D-glucopyranosides (IX), kaempferol-3-O-(6"-acetyl) -beta-D-glucopyranosides (X), glucose (XI).

[Dynamic observation of applying repairing laryngeal mucosal defect with heterogeneous acellular dermal matrix].

Objective: To study the clinical effect of heterogeneity (cattle) acellular dunal matrix in repairing mucosa defect in laryngeal surgery.

Methods: Eighteen cancer patients with mucosa defect in central vocal area accepted treatment with heterogeneity acellular dunal matrix after surgery. There were two methods to repair mucosa defect.

Effects of NT-4 gene modified fibroblasts transplanted into AD rats.

It is well known that fibroblasts can act as a cell vector to express functional protein, like neurotrophin-4 (NT-4). The present study evaluated the effect of NT-4 gene modified fibroblasts grafted into the hippocampus of AD rat model. AD rats were reproduced by bilateral transection of the hippocampal fimbria-fornix.

[Design and analysis of automatic measurement instrument for diffraction efficiency of plane reflection grating].

A new-style system that automatically measures the diffraction efficiency of plane reflection grating was designed. The continuous illuminant was adopted for illumination, the duplex grating spectrograph structure was applied, and the linear array NMOS was the receiving component. Wielding relevant principle of the grating spectrograph, theoretical analysis principle was carried out for the testing system.

[Distribution and change of NGF, BDNF and NT3 in the hippocampus of rat with AD].

Objective: To investigate the distribution and change of NGF, BDNF and NT3 in hippocampus of rat with Alzheimer disease(AD) by immunohistochemistry.

Methods: AD model was established by injecting beta amyloid protein into the hippocampus of rat. The rats were killed ten days after injection.