Evaluation of the Activity and Efficacy of Anidulafungin-Loaded Human Serum Albumin Nanoparticles Against .

Recent decades have seen a significant increase in invasive fungal infections, resulting in unacceptably high mortality rates. Anidulafungin (AN) is the newest echinocandin and appears to have several advantages over existing antifungals. However, its poor water solubility and burdensome route of administration (i.

Early mechanical cardiopulmonary resuscitation can improve outcomes in patients with non-traumatic cardiac arrest in the emergency department.

Objective: To compare the outcomes of patients with non-traumatic cardiac arrest (CA) who received early versus late mechanical cardiopulmonary resuscitation (CPR) with the Lund University Cardiac Assist System (LUCAS) device in the emergency department (ED).

Methods: This was a retrospective observational study in the ED of a single medical center performed from May 2018 to December 2019; 68 patients with CA were eligible. We grouped the patients according to the time to initiating LUCAS use after CA into an early group (≤4 minutes) and late group (>4 minutes).

CircRNA FGFR3 induces epithelial-mesenchymal transition of ovarian cancer by regulating miR-29a-3p/E2F1 axis.

Circular RNAs (circRNAs) are a class of non-coding RNAs that regulate gene expression after transcription. However, the specific function of circRNAs in ovarian cancer remains undetermined. Previous studies have demonstrated abnormal expression of circFGFR3 in several cancers.

Moderate salt treatment alleviates ultraviolet-B radiation caused impairment in poplar plants.

The effects of moderate salinity on the responses of woody plants to UV-B radiation were investigated using two Populus species (Populus alba and Populus russkii). Under UV-B radiation, moderate salinity reduced the oxidation pressure in both species, as indicated by lower levels of cellular H2O2 and membrane peroxidation, and weakened the inhibition of photochemical efficiency expressed by O-J-I-P changes. UV-B-induced DNA lesions in chloroplast and nucleus were alleviated by salinity, which could be explained by the higher expression levels of DNA repair system genes under UV-B&salt condition, such as the PHR, DDB2, and MutSα genes.

Complete genome sequence and comparative genome analysis of the Paenibacillus mucilaginosus K02.

Aim: Paenibacillus mucilaginosus (P. mucilaginosus) K02 is implicated in mineral weathering. However, relevant molecular mechanisms remain obscure.

A high level of TM4SF5 is associated with human esophageal cancer progression and poor patient survival.

Purpose: We investigated expression of TM4SF5 and its involvement in human esophageal cancer (HEC).

Methods: We analyzed TM4SF5 expression in normal esophageal epithelial cells (HEEC), in four HEC cell lines, and in 20 HEC clinical tissue samples and matched nontumor samples. The effect of TM4SF5 on HEC cell proliferation and metastasis and invasion was assessed, and the relationship between TM4SF5 and integrin β1 was determined.

[Altitudinal changes in leaf mass per unit area and tissue non-structural carbohydrates content of Abies fabri on Gongga Mountain of southwest China].

Taking the northeast slope of Moxi vally and southwest slope of Kangding vally in Gongga Mountain of Southwest China as sampling sites, this paper investigated the leaf mass per unit area (LMA) and tissue non-structural carbohydrates content (NSC) of Abies fabri distributed at the positions from lower elevations to alpine treeline during the periods of dormancy and vigorous growth. The results indicated that A. fabri had higher LMA and NSC in warm-moist Moxi valley than in hot-dry Kangding valley.